US 7,459,309 B2
	Isolated polypeptide deletion mutants of survival of motor neuron-interacting protein 1
Gideon Dreyfuss, Wynnewood, Pa. (US); Utz Fischer, Gauting (Germany); Qing Liu, Winchester, Mass. (US); Bernard Charroux, Carry le Rouet (France); and Livio Pellizzoni, Rome (Italy)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, Pa. (US)
Filed on Oct. 02, 2003, as Appl. No. 10/677,662.
Application 10/677662 is a division of application No. 09/399081, filed on Sep. 17, 1999, granted, now 6,646,113.
Claims priority of provisional application 60/100866, filed on Sep. 17, 1998.
Prior Publication US 2005/0100923 A1, May 12, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 21/04 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); C12N 5/10 (2006.01); C07K 14/435 (2006.01)

U.S. Cl. 435—325  [435/320.1; 435/252.3; 536/23.1; 536/23.5; 536/24.1; 530/350]

8 Claims

1. An isolated nucleic acid encoding a human Survival of Motor Neuron-Interacting Protein 1, wherein said nucleic acid encodes a polypeptide comprising SEQ ID NO: 2 that differs from the amino acid sequence of SEQ ID NO: 2 by a mutation that inhibits binding of Survival Motor Neuron-Interacting Protein 1 with Survival Motor Neuron protein, wherein said mutation is selected from the group consisting of a deletion of the carboxyl terminal 89 amino acids relative to the amino acid sequence of SEQ ID NO: 2 and a deletion of the carboxyl terminal 162 amino acids relative to the amino acid sequence of SEQ ID NO: 2, and further wherein said nucleic acid comprises a nucleic acid encoding a tag polypeptide covalently linked thereto.