CBB seminar 11 AM, Tuesday March 7, 2000 NIH Bldg. 38A, 8th floor conference room Detlef D. Leipe The NCBI taxonomy database - structure, philosophy, applications, future developments. ABSTRACT The NCBI taxonomy database is a relational database that primarily 1. stores the scientific names of all organisms that have been sequenced and 2. provides a hierarchical classification of these organisms that strives to reflect phylogeny (i.e., the tree of life). The NCBI taxonomy database is curated by five in-house scientists and it provides the taxonomy to the NCBI, the collaborating database EBI/EMBL, and DDBJ and SWISSPROT. The NCBI database currently contains about 65000 species, and the number doubles about every two years. I will give a general introduction to the curation of the taxonomy database, discuss some of the problems and limitation and will conclude with a preview of some of the tools that are devloped to take more advantage of the taxonomic information when formulating BLAST queries and viewing BLAST results. Work is also underway to provide an ENTREZ type taxonomy interface and I hope to also show a preview of that.