1. Sponsor Organization: Department of the Environment, Food and Rural Affairs

2. Project Title: Relational Database of Information on Potential Endocrine Disrupters (REDIPED)

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus: Exposure Assessment

4. Description:

A relational database is being developed to enable access to data on potential endocrine disrupters that will assist the process of prioritising chemicals for regulatory action and aid in the identification of knowledge gaps. Data include physicochemical properties, chemical fate and behaviour, environmental degradation, exposure assessment and biological activity, cited from peer-reviewed references. REDIPED currently holds information on 79 chemicals and will be available for general use by 2002.

5. References:

1. Author: MRC Institute for Environment and Health
   Title: Environmental oestrogens: consequences to human health and wildlife
   Citation: Assessment A1. Leicester, UK, Institute for Environment and Health
   Year: 1995
   

2. Author: MRC Institute for Environment and Health
   Title: The ecological significance of endocrine disruption: effects on reproductive function and consequences for natural populations.
   Citation: Assessment A4. Leicester, UK, Institute for Environment and Health
   Year: 1999
   

6. Inventory Category:

• Primary: Methods
• Secondary:

7. Inventory Subcategory:

• Primary: Database Development
• Secondary:
  • Multidisciplinary Research

8. Keywords for Experimental System/Species:

• Species:
  • invert
  • fish
  • amphib
  • reptil
  • avian
  • mammal
  • rodent
• Study Type:
  • In Vitro
  • In Vivo
  • Ex Vivo
  • Laboratory Study
• Fate and Transport:
  • Exposure Monitoring
  • Environmental Fate and Transport
  • Bioaccumulation

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Carcinogenesis
  • Neurological
  • Immunology
  • Reproductive
  • Metabolism
• Hormonal Measures:
  • Adrenal Hormones
  • Growth Factors
  • Hormone Receptors
  • Peptide Hormones
  • Pituitary Hormones
  • Sex Steroids
  • Thyroid Hormones
• Level Of Study:
  • Behavior
  • Histopathology
  • Physiology
  • Biochemistry
  • Gene Expression
  • Transgenic Model
• Chemistry Metabolism:
  • Tissue Residue
  • Analyte Detection
  • Exposure Monitoring
• Life Stage:
  • Multigeneration
  • Female
  • Male
  • Embryo
  • Infant
  • Puberty
  • Adult
  • Metamorphosis
• Risk Assessment:
  • Biologically based-dose response

10. Chemical Agents:

• Alkylphenols
• Androgens/Anti-Androgens
• Diethylstilbestrol
• Dioxins
• Estrogens/Anti-Estrogens
• Fungi
• Herbicides
• Organochlorines
• PCBs
• insecticides
• PCDDs
• PCDFs
• Pesticides
• Phenol
• Phthalates
• Phytoestrogens

11. Performing Institution:

• MRC Institute for Environment and Health

12. Contact:

• Dr Paul Harrison
  MRC Institute for Environment and Health
  94 Regent Road
  Leicester, LE1 7DD, United Kingdom
  + 44 (0) 116 223 1600
  ptch1@le.ac.uk

Institution: MRC Institute for Environment and Health
Division:
Given Name:
Name: Dr Paul Harrison
Title:
Form:
E-Mail: ptch1@le.ac.uk
Phone: + 44 (0) 116 223 1600
Fax:
Street: 94 Regent Road
Zip:
City: Leicester, LE1 7DD, United Kingdom
State:
Country:

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