1. Sponsor Organization: DEFRA

2. Project Title: Relational Database of Information in Potential Endocrine Disrupters (REDIPED)

3. Project Focus:

• Project Primary Focus: Human Health Effects
• Project Secondary Focus: Exposure Assessment

4. Description:

A relational database has been developed to enable access to data on potential endocrine disrupters, in order to assist in the process of the prioristisation of chemicals and aid in the identification of knowledge gaps. Data includes physicochemical properties, chemical fate and behaviour, environmental degradation, exposure assessment and biological activity, cited from peer-reviewed references. Currently, REDIPED holds information on 79 chemicals and will be available for general use by 2002.

5. References:

1. Author: MRC Institute for Environment and Health
   Title: Environmental oestrogens: consequences to human health and wildlife.
   Citation: Assessment A1. Leicester, UK, Institute for Environment and Health.
   Year: 1995
   

2. Author: MRC Institute for Environment and Health
   Title: Assessment on the ecological significance of endocrine disruption: effects on reproductive function and consequences for natural populations.
   Citation: Assessment A4. Leicester, UK, Institute for Environment and Health.
   Year: 1999
   

6. Inventory Category:

• Primary: Methods
• Secondary: Models

7. Inventory Subcategory:

• Primary: Database Development
• Secondary:
  • Multidisciplinary Research

8. Keywords for Experimental System/Species:

• Species:
  • invert
  • fish
  • amphib
  • reptil
  • avian
  • mammal
  • rodent
• Study Type:
  • In Vitro
  • In Vivo
  • Ex Vivo
  • Laboratory Study
• Fate and Transport:
  • Exposure Monitoring
  • Environmental Fate and Transport
  • Bioaccumulation

9. Keywords for Experimental Endpoints:

• Health Effect:
  • Carcinogenesis
  • Neurological
  • Immunology
  • Reproductive
  • Metabolism
• Hormonal Measures:
  • Adrenal Hormones
  • Growth Factors
  • Hormone Receptors
  • Peptide Hormones
  • Pituitary Hormones
  • Sex Steroids
  • Thyroid Hormones
• Level Of Study:
  • Behavior
  • Histopathology
  • Physiology
  • Biochemistry
  • Gene Expression
  • Transgenic Model
• Chemistry Metabolism:
  • Analyte Quantification
  • Exposure Monitoring
  • Tissue Residue
• Life Stage:
  • Female
  • Male
  • Embryo
  • Infant
  • Puberty
  • Adult
  • Metamorphosis
  • Multigeneration
• Risk Assessment:
  • Biologically based-dose response

10. Chemical Agents:

• Alkylphenols
• Androgens/Anti-Androgens
• Diethylstilbestrol
• Dioxins
• Estrogens/Anti-Estrogens
• Fungi
• Herbicides
• Organochlorines
• PCBs
• insecticides
• PCDDs
• PCDFs
• Pesticides
• Phenol
• Phthalates
• Phytoestrogens

11. Performing Institution:

• MRC INSTITUTE FOR ENVIRONMENT AND HEALTH

12. Contact:

• Dr Paul Harrison
  MRC INSTITUTE FOR ENVIRONMENT AND HEALTH
  94 REGENT ROAD
  LEICESTER, LE1 7DD, UK
  ++ (0) 116 223 1600
  ieh@le.ac.uk

Institution: MRC INSTITUTE FOR ENVIRONMENT AND HEALTH
Division:
Given Name:
Name: Dr Paul Harrison
Title:
Form:
E-Mail: ieh@le.ac.uk
Phone: ++ (0) 116 223 1600
Fax:
Street: 94 REGENT ROAD
Zip:
City: LEICESTER, LE1 7DD, UK
State:
Country:

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