Arnsten JH, Freeman R, Santoro N, Kunins H, Schoenbaum EE; Conference on Retroviruses and Opportunistic Infections.

9th Conf Retrovir Oppor Infect Feb 24 28 2002 Wash State Conv Trade Cent Seattle Wash Conf Retrovir Oppor Infect 9th 2002 Seattle Wash. 2002 Feb 24-28; 9: abstract no. 717-T.

Montefiore Med. Ctr., Bronx, NY

BACKGROUND: Osteopenia is a recently described adverse event in HIV-infected patients that may be a side effect of protease-inhibitor use, and is also a well-known sequela of menopause and normal aging in women. To date, no studies have described the prevalence of reduced bone mineral density BMD in older, peri- and post-menopausal HIV-infected women.METHODS: We analyzed BMD of the lumbar spine, hip, and total body in 40 older (age >35) women, including 19 HIV-infected and 21 HIV-uninfected women. We also analyzed the impact of protease-inhibitor (PI) use on BMD.RESULTS: The median age of subjects was 48 years (range 35-55). 50% (n=20) were defined as post-menopausal (age >40 and no menses in the past one year), and 50% were defined as perimenopausal (age >35 and irregular menses, or age >40 and regular menses). 49% were African American, 32% Hispanic, and 19% white. Mean body weight was 72.5 kg (range 48-106). Among HIV-infected women, all had taken antiretroviral therapy and 55% (n=11) had taken PIs. The prevalence of osteopenia (defined as lumbar spine, femoral neck, or total body T-score < -1.0) was 50% among HIV-infected post-menopausal women, 44% among HIV-uninfected post-menopausal women, 25% among HIV-infected peri-menopausal women, and 40% among HIV-uninfected peri-menopausal women. Among HIV-infected women, 60% of PI-using women had osteopenia compared to 13% of women who had not used PIs (p=0.04), and this association remained after controlling for age and body weight. Mean BMD and median t-scores for the lumbar spine (LS) and femoral neck (hip) are shown in the table: [table: see text]CONCLUSIONS: Protease inhibitor use is independently associated with significantly decreased bone mineral density in older HIV-infected women.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Bone Density
• Bone Diseases, Metabolic
• Female
• HIV Infections
• HIV Seropositivity
• Hip
• Humans
• Lumbar Vertebrae
• Menopause
• Prevalence
• Protease Inhibitors

Other ID:

• GWAIDS0024161

UI: 102263785

From Meeting Abstracts