Cohen MH, Greenblatt R, Minkoff H, Barkan S, Burns D, Denenberg R, Young M, Levine A; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 28 (abstract no. Mo.B.540).
Chicago, IL, USA. Fax: (312) 633-4902. E-mail: mcohen@hektoen.org.
Objective: To determine the prevalence and etiology of amenorrhea and to describe menstrual abnormalities in women with HIV infection. Methods: The Women's Interagency HIV Study (WIHS) is a multi-site cohort study of HIV-infected women and a comparable at risk uninfected control group. Data for this analysis was available on 1416 women. Women were excluded if they were pregnant, lactating, or self reported being post-menopausal, having had a hysterectomy or bilateral oophorectomy. We included 1,002 women (797 HIV-infected, 205 HIV-uninfected) in the analysis for amenorrhea (defined as no menses within the past 90 days). For menstruating women, questions regarding menstrual abnormalities were analyzed by serostatus. Results: Prevalence of amenorrhea was 5.5% in HIV-infected women and 3.9% in the HIV-seronegative group. Amenorrhea rates increased to 12.3% in HIV-infected women with CD4 count less than 50. Current heroin use, recent injection drug use, increased alcohol consumption, and albumin less than 3 were significantly associated with amenorrhea. Hormone analyses including LH/FSH and estradiol will be presented for amenorrhea etiology determination. Menstrual cycle abnormalities reported within the past 6 months included: prolonged average menses greater than 7 days (36%), irregular menses (62.6%), skipped menses (15.7%), spotting or bleeding between menses (15.4%), and post coital bleeding (6.5%). These rates were comparable in HIV-infected and in at risk HIV-negative women. Conclusion: Although the prevalence of amenorrhea was comparable among HIV-infected and uninfected women, women with very low CD4 cell counts reported the condition significantly more frequently than others. Menstrual abnormalities are common and occur at similar rates in HIV-infected and at risk HIV-negative women. These findings suggest that HIV-related disease progression influences the occurrence of menstrual cycle abnormalities, though HIV infection itself does not.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Cohort Studies
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Menstrual Cycle
- Menstruation
- Menstruation Disturbances
- Prevalence
- Substance-Related Disorders
Other ID:
UI: 102216844
From Meeting Abstracts