DAVID Gene Report
2875977
chemokine (c-x-c motif) ligand 12 (stromal cell-derived factor 1) Related Genes Homo sapiens
SP_COMMENT
PTM:Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.,
function:Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.,
similarity:Belongs to the intercrine alpha (chemokine CxC) family.,
subcellular location:Secreted.,
OMIM_DISEASE
AIDS, resistance to ,
REFSEQ_PROTEIN
NP_000600 ,
NP_001029058 ,
NP_954637 ,
ENTREZ_GENE_SUMMARY
For background information on chemokines, see CXCL11 (SCYB11; MIM 604852). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM],
REFSEQ_MRNA
NM_000609 ,
NM_001033886 ,
NM_199168 ,
GENPEPT_ACCESSION
AAA97434 ,
AAB39332 ,
AAB39333 ,
AAB40516 ,
AAH39893 ,
AAT76437 ,
AAV49999 ,
AAW82036 ,
ABC69270 ,
ABC69271 ,
ABC69272 ,
ABC69273 ,
BAC03463 ,
BAC85913 ,
BAF85317 ,
CAC10202 ,
CAC10203 ,
CAD28539 ,
CAG29279 ,
CAJ21099 ,
CAJ21100 ,
EAW86618 ,
EAW86619 ,
EAW86620 ,
EAW86621 ,
Genomic_DNA ,
mRNA ,
GENE_SYMBOL
Cxcl12 ,
GENE_NAME
C-X-C motif chemokine 12,
CDNA FLJ42650 fis, clone BRACE3027478,
Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1), isoform CRA_b,
Cxcl12 protein,
FLJ00404 protein,
FLJ00404 protein (Fragment),
PBSF,
Pre-B cell growth-stimulating factor,
SDF-1,
Stromal cell-derived factor 1,
Stromal cell-derived factor 1 gamma,
Stromal cell-derived factor 1 precursor,
Stromal cell-derived factor 1 precursor (SDF-1) (C-X-C motif chemokine 12) (Pre-B cell growth-stimulating factor) (PBSF) (hIRH) [Contains: SDF-1-beta(3-72); SDF-1-alpha(3-67)],
Stromal cell-derived factor 1a,
cDNA FLJ76575, highly similar to Homo sapiens chemokine (C-X-C motif) ligand 12 (stromalcell-derived factor 1) (CXCL12), mRNA,
chemokine (C-X-C motif) ligand 12,
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1),
hIRH,
GENERIF_SUMMARY
SDF1 is involved in astrocyte division and MAP kinase signal transduction. ,
Association of stromal cell-derived factor 1 genotype with disease progression of HIV infection ,
exerts an antiapoptotic effect on CD34(+) hematopoietic progenitor cells through an autocrine/paracrine regulatory loop ,
the presence of the SDF-1 3'A gene correlates with accelerated disease progression in HIV-1-infected children born to seropositive mothers but does not protect against mother-to-child HIV-1 transmission ,
elastase-mediated proteolysis of SDF-1/CXCR4 is part of a mechanism regulating their biological functions in both homeostatic and pathologic processes ,
These findings support a pivotal role for HEC-expressed CXCL12 and its receptor on T cells in the regulation of T lymphocyte homing to lymph nodes. ,
B-cell chemotaxis responsiveness to SDF-1alpha is profoundly suppressed by surrogate antigen. ,
SDF1 is expressed in medullar epithelial cells forming Hassall's corpuscles and demonstrates a potential role in the elimination of apoptotic thymocytes in normal and HIV-1-infected thymic tissues. ,
The frequencies of SDF1 mutation associated with the development of clinical symptoms upon infection with human immunodeficiency virus type 1 (HIV-1) were determined in a cohort of individuals from Moscow ,
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. ,
Regulation of endothelial cell branching morphogenesis ,
CXCR4/CXCL12 expression and signalling in kidney cancer ,
Up-regulation by SDF-1 alpha of lymphocyte adhesion mediated by integrin alpha 4 beta 7 could contribute to lymphocyte homing to mucosa-associated lymphoid tissues. ,
leukemic Philadelphia chromosome-positive (Ph+)CD34+ cells from newly diagnosed CML patients that express the chemokine receptor CXCR4 migrate in response to stromal-derived factor-1 (SDF-1) ,
role in HIV-1 entry ,
induced transient activation of ERK1/2, ribosomal S6 kinase (p90RSK) and Akt, molecules implicated in cell survival. SDF1A also acted synergistically with other cyotkines. ,
Lck is required for stromal cell-derived factor 1 alpha (CXCL12)-induced lymphoid cell chemotaxis. ,
SDF-1alpha may play a role in the neuronal response to HIV in the brains of AIDS patients. ,
SDF-1/CXCL12 upregulated T-cell activation, and a G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12. ,
Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in Jurkat cells, a T-lymphocyte line. ,
The stimulating effect of GAGs was caused by the formation of a stable haptotactic SDF-1 gradient, as SDF-1 bound to immobilized GAGs and triggered HSC migration. Dimerization of presented SDF-1 or increased binding to CXCR4 are possible mechanisms. ,
CCR5-binding chemokines modulate induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor. ,
signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion ,
beta-arrestin2 can function not only as a regulator of CXCR4 signaling but also as a mediator of stromal cell-derived factor 1alpha-induced chemotaxis, via the ASK1/p38 MAPK pathway ,
Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling ,
migration of murine and human IFN-producing cells to CXCR3 ligands in vitro requires engagement of CXCR4 by CXCL12 ,
SDF-1alpha plays an important regulatory role in the altered B-cell responses seen in HIV-1 infection. ,
expressed in human brain tumors and is involved in glial proliferation in vitro ,
results indicate that normal human hematopoietic stem and progenitor cells express functional C3aR and that the C3aR-C3a axis sensitizes the responses of these cells to SDF-1 ,
In human bone marrow, CXCL12 triggers a sustained adhesion response specifically in progenitor (pro- and pre-) B cells. ,
plasma stromal cell-derived factor-1 levels in normal healthy donors for allogeneic peripheral blood stem cell transplantation (PBSCT) and in patients for autologous PBSCT ,
Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. ,
Sdf1 is expressed in myocardium and skeletal muscle. ,
invading extravillous trophoblasts that eventually perform endovascular invasion express CXCL12, the ligand for CXCR4, but not ligands for CXCR3. ,
SDF-1 enhanced the expansion and differentiation of primitive cord blood cells in a manner that was dependent upon both the concentration of SDF-1 and the presence of specific cytokines ,
examination of expression in prostate cancer ,
SDF-1-dependent polarization of CXCR4 is promoted by leukocyte-endothelium interaction ,
SDF-1 activated MMP-9 in bone marrow (BM) cells, causing release of soluble Kit-ligand and transfer of hematopoietic stem cells from a quiescent to a proliferative niche ,
TGF-beta1-controlled reduction in SDF-1 expression influences bone marrow cell migration and adhesion, which could affect the motility of cells trafficking the bone marrow. ,
Factors other than alteration in SDF-1/CXCR4 chemokine system must account for marrow infiltration of neoplastic cells in B-cell chronic lymphocytic leukemia. ,
role in regulating ERK activation in lymphocytes by phophatases ,
SDF-1alpha stimulates prolonged activation of extracellular signal-regulated kinases ERK1 and ERK2 in Jurkat T lymphocytes via a mechanism requiring Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76) scaffold protein and ZAP-70 kinase. ,
Increased sdf1a expression in basal ganglia neurons of patients with advanced HIV CNS disease suggests it may also contribute to pathogenesis. ,
HGF, SDF-1, and MMP-9 have roles in stress-induced human CD34+ stem cell recruitment to the liver ,
results confirm a role for SDF-1alpha and IL-7 in HIV-1 disease progression, and suggest that these cytokines play a role in the modulation of CXCR4 ,
Carboxyphosphorylated-ERM dephosphorylation begins within seconds of stimulation by chemokine SDF-1 alpha or secondary lymphoid tissue cytokine and ERM proteins lose their punctate distribution with kinetics paralleling the loss of microvilli. ,
By triggering specific adhesion of circulating KSHV-infected cells and favoring their entry into the extravascular cutaneous space, endothelial cell-associated SDF-1 in cutaneous capillaries may dictate the preferential occurrence of KS in the skin. ,
Inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to this constitutive chemokine. ,
Serum modification and inactivation contribute to the failure of SDF-1 to block HIV-1 infection and spread in man. ,
the SDF-1/CXCR4 ligand/receptor pair is likely to play an important functional role in T lymphocyte accumulation and positioning within the rheumatoid synovium. ,
The differential processing of SDF-1alpha and SDF-1beta provides biologic significance to the existence of 2 splice forms of the chemokine. ,
BMECs produce and release small amounts of SDF-1 and express CXCR4 in vivo only ,
both at molecular and protein levels CXCL10 and CXCL12 significantly increased only when cells were differentiated on calcium phosphate-coated slides ,
In the present study we report that two toxins from Clostridium species which inhibit the small GTPase Rho suppressed SDF-1alpha-induced generation of intracellular calcium transients in HPC. ,
Results show that the stromal-derived factor-1alpha/CXCR4 axis is involved in the dissemination of non-small cell lung cancer cells into pleural space. ,
SDF-1/CXCL12 inhibited cAMP production in response to adenylyl cyclase activator forskolin; inhibition abrogated by anti-CXCR4 antibody or receptor desensitization. Inhibited forskolin-induced ion transport in voltage-clamped polarized T84 cells. ,
We observed a statistically significant decrease in the levels of SDF-1 on myeloma cells in four consecutive apheresis collections compared with premobilization bone marrow specimens. ,
early tissue-specific stem cells reside in normal human and murine bone marrow, express the CXCR4 receptor on their surface and can be highly enriched (in humans and mice) after chemotaxis to SDF-1 gradient ,
Important mechanistic role for CXCR4 and SDF-1/CXCL12 in regulating angiogenesis within the human intestinal mucosa. ,
CCL19 and CXCL12 have roles in chemotaxis of mantle cell lymphoma B cells ,
first-trimester trophoblast cells express functional CXCR4/CXCL12, which may play an important role in early pregnancy such as stimulating trophoblast cell proliferation or differentiation in an autocrine manner ,
the endogenous CXCL12/CXC-chemokine receptor 4 signaling axis is critical for neuroblastoma cell survival and proliferation ,
the altered leukocyte response to CXCL12 may account for the pathologic retention of mature polymorphonuclear cells in the bone marrow (myelokathexis) and for an altered lymphocyte trafficking in WHIM syndrome ,
syndecan-4/CXCR4 complex is likely a functional unit involved in SDF-1 binding ,
this study suggested that stromal cell-derived factor 1 can influence neural progenitor cells function through CXCR4 and that CXCR4 is functional on neural progenitor cells ,
CD26/DPPIV is likely to directly modulate various SDF-1alpha induced functions ,
study provides the first evidence for SDF-3'A polymorphism in resistance to HIV-1 infection in Thais ,
study indicates that lymphoma patients from Brazil are more likely to carry the 3'A gene than patients with lymphoid leukemias, suggesting that this polymorphism may be a differential determinant of lymphomas and lymphoid leukemia. ,
SDF-1alpha and its receptor chemokine receptor CXCR4 induced transendothelial breast cancer cell migration through activation of the PI-3K/AKT pathway and Ca(2+)-mediated signaling. ,
These findings suggest that the interaction between SDF-1 and CXCR4 ligand-receptor system is involved in the process of PC metastasis by the activation of cancer cell migration. ,
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. ,
A mutant SDF-1 that does not interact with heparan sulsfate is readily cleaved by dipeptidyl peptidase IV. ,
Incubation with single chain Fv antibodies results in reduction of CXCL12-induced calcium mobilization in prostate cancer cells. ,
Dok-1 plays an important role in SDF-1alpha/CXCL12-induced chemotaxis in T cells. ,
CXCL12 signaling via CXCR4 directs intestinal epithelial cell migration, barrier maturation, and restitution, consistent with an important mechanistic role for these molecules in mucosal barrier integrity and innate host defense. ,
T lymphocyte transendothelial migration was inhibited by treatment of HUVEC with purified neutrophil elastase, which selectively cleaved the amino terminus of HUVEC-bound SDF-1alpha. ,
CXCR4/CXCL12 axis may participate in the EBV-associated lymphomagenesis process in immunodeficient hosts. ,
Mechanisms of CXCR4/CXCL12-mediated prostate cancer cell migration and invasion. ,
SDF-1 acts through ERK1/2 signalling pathway as a trophoblast survival factor. ,
HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves ,
Stromal cell-derived factor-1 is an important factor influencing the mobilization of early tissue-committed cells expressing cardiac, muscle, and endothelial markers in myocardial infarction. ,
SDF1a has a role in migration of hematopoietic stem cells ,
Bone marrow strongly expresses functional stromal-derived factor (CXCL12), the ligand for CXCR4 ,
potent activator of MAP kinases akt-dependent pathways in neuronal and non-neuronal cells ,
SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos ,
stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway has roles in migration of neural stem cells to sites of CNS injury ,
CXCL12 signaling is independent of Jak2 and Jak3 ,
SDF-1 plays a major role in proliferative retinopathy and may be an ideal target for the prevention of proliferative retino ,
SDF-1 triggered protein kinase C, zeta phosphorylation, translocation to the plasma membrane, and kinase activity ,
Our data support participation of SDF-1 in pathogenesis of rheumatoid arthritis and in progression of joint destruction. ,
SDF-1, may play a role in the maintenance, survival, and osteogenic capacity of immature bone marrow stromal stem cell populations ,
decreased circulating CD26 levels in arthritis may influence CD26-mediated regulation of the chemotactic SDF-1/CXCR4 axis ,
SDF1 gene variant is present in patients with type 1 diabetes mellitus and autoimmune thyroid disease. ,
Increased SDF1 expression is associted with osteosarcoma tumor progression ,
These results demonstrate that Syk participates in CXCL12-induced cell polarization, which occurs in concert with cell adhesion mediated by beta1 integrin. ,
carboxypeptidase N regulates the biologic activity of SDF-1alpha by reducing the chemokine-specific activity ,
perturbation of SDF-1 during B-cell recovery retards neutrophil egress from the bone marrow; findings illustrate the dual role of SDF-1 in human B-cell and granulocyte homeostasis ,
CXCL12-induced focal adhesion kinase activation and its recruitment to lipid rafts in progenitor B cells are critical parameters of CXCL12-induced chemotactic and adhesive responses in lipid rafts. ,
Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients ,
Frequency distribution of SDF1-3'A mutations in Brazilian Amazon region ,
Genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes. ,
CHK down-regulates CXCR4 through the YY1 transcription factor, leading to decreased CXCR4/CXCL12-mediated breast cancer cell motility and migration. ,
Data demonstrate that specific stimuli mediate stromal-cell derived factor 1 production through promoter activation in a cell-specific manner. ,
SDF-1 related to invasion, migration, and growth of breast cancer cells; breast cancer cells equiped with CSF-1 autocrine circuit display more aggressive phenotype and greater growth ability ,
CXCL12 directly binds to syndecan-4 in a glycosaminoglycan-dependent manner ,
Akt activation, but not ERK1/2 activation, is required for SDF-1alpha-induced migration of epitheloid carcinoma cells ,
JUN-dependent expression of PTN and SDF-1 in fibroblasts has a role in keratinocyte proliferation ,
In an organotypic melanoma culture model, cytotoxic T cells (CTL) mediated by CXCL12 secreted by the melanoma cells migrate from the top layer through the collagen/fibroblast separating layer toward the tumor cells, resulting in tumor cell apoptosis. ,
prostate cancers may be influenced by the CXCL12 ,
activation of Vav1-Rac signaling pathway by CXCL12 represents an important inside-out event controlling efficient up-regulation of alpha4beta1-dependent T lymphocyte adhesion ,
Findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1. ,
analysis of the role of the SDF-1-CXCR4 axis in trafficking of normal stem cells and metastasis of cancer stem cells ,
co-overexpression of coactivators and her2/neu with poor prognosis ,
These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer. ,
AA and AG genotypes of SDF-1 may have a role in the susceptibility of Iranian patients to lung cancer ,
Data suggest that CXCL12 and CXCL13 may directly modulate cellular proliferation and collagen type I in osteoarthritis patients. ,
first-trimester trophoblast cells produce CXCL12, which in turn chemoattracts decidual CD56(bright)CD16(-) NK cells ,
AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer ,
SDF-1 can increase the invasiveness and migration of breast cancer cells; its levels correlated with node involvement and long-term survival in patients with breast cancer ,
RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes ,
Over expression of stromal cell derived factor-1 promotes glioma invasiveness through membrane type-2-matrix metalloproteinase ,
RDC1, which we propose to rename as CXCR7, is a receptor for CXCL12 ,
SDF-1-alpha increases endothelial proliferation and migration involving the activation of BK(Ca) and an increased production of NO. ,
CXCL12/CXCR4 axis is expressed in prostate cancer bone metastasis and exogenous CXCL12 induced MMP-9 expression. ,
C3a increased the binding affinity of CXCL12 to human CXCR4(+)/C3aR(-), REH pro-B cells, which is compatible with a direct interaction between C3a and CXCL12 ,
IGF-I may act to limit atrophy and apoptosis during reverse remodeling and to promote repair and regeneration in concert with stromal cell derived factor. ,
Haplotype analysis of SDF-1 in a longitudinal HIV-1/AIDS cohort study found significant associations for two single nucleotide polymorphisms and one haplotype in African Americans. ,
The SDF1-3'A SNP (single nucleotide polymorphism) was associated with an increased risk for HIV-1 infection (P = 0.0319). ,
SDF1-3'A polymorphism plays a role in thrombotic risk in chronic myeloproliferative diseas ,
Results strongly suggest that the CXCR4/CXC12 axis plays an important role in the development of peritoneal carcinomatosis from gastric carcinoma. ,
The SDF-1/CXCR4 axis promotes hematopoietic stem/progenitor cell proliferation in contact with mesenchymal stem cells. SDF-1 stimulates retention of HSPC in MSC niches which expose them to stimulatory and inhibitory factors in a paracrine manner. ,
results implicate CD45, Cbl, Cbl-b, src kinases and potentially other associated proteins as mediators of SDF-1alpha/CXCL12-induced cell migration of Jurkat T cells ,
Attachment of CXCL12 to heparan sulfate proteoglycans is upregulated by inflammatory cytokines. Upregulation of chemokine during chronic inflammation and HSPG-dependent immobilization of CXCL12 in endothelial cells have therapeutic potential. ,
SDF1-3'A allele may not be sufficient to prevent the risk of HIV-1 infection and may be unrelated to the progression of HIV-1 infection in the Brazilian population. ,
Since we demonstrated that not only SDF-1, but also HGF and LIF are upregulated in damaged tissues, we postulate that CXCR4+ c-Met+ LIF-R+ TCSC could be mobilized from the BM into the PB, where they play a role in tissue repair/regeneration. ,
CXCL12, the c-myc-regulated gene is involved in genotype-C-HBV-related HCC, suggesting that c-myc is related to the hepatocarcinogenic activity of genotype-C HBV. ,
we hypothesized that the tumor environment in the lymph nodes may cause the reduction of CXCR4 levels in the metastatic tumor cells because of ,
there is a significant elevation of SDF-1 expression in the subacromial bursa of patients with rotator cuff disease ,
Our findings suggest that increased CXCL12 may initiate and augment the inflammatory response during MS. ,
Gene is associated with acute myeloid leukemia and with the risk of distant tissue infiltration by tumor cells. ,
Adenosine increases cell-surface CXCR4 protein, which enables the carcinoma cells to migrate toward CXCL12. ,
SDF-1alpha has an important role in CD34+/CXCR4+ progenitor cell mobilization after cardiac surgery. ,
low levels of SDF-1alpha in breast cancer cells regulate interactions between BM stroma and hematopoietic progenitors, consequently facilitating normal hematopoiesis. ,
existence of an additional receptor(different from CXCR4) through which CXCL12 exerts its biological effects in endothelial cells ,
Induces tyrosine phosphorylation of cortactin, leading to extracellular signal-regulated kinase activation and chemotaxis. ,
SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may have a role in progression of chronic lymphocytic leukemia ,
Preferential role of in cytotoxic T lymphocyte migration toward melanoma cells. ,
In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed. ,
Microvascular endothelial cellsfrom patients with systemic sclerosisexpressed significantly higher amounts of both isoforms of SDF-1 in the early stage of disease. ,
Patients with RA had a significantly and constantly increased p-CXCL12 level compared to controls. ,
Rsults support the hypothesis that the mutation of allele SDF1-3'A could have a possible late-stage protective effect on HIV-1 disease progression in the Brazilian population. ,
SDF-1-CXCR4 axis contribute to invasiveness of Human Cervical Carcinoma cells. ,
Tax expression correlated with activation of the SDF-1/CXCR4 axis ,
comparison of DOCK2 and Vav1 involvement in CXCL12-promoted Rac activation and alpha4beta1-dependent human T cell adhesion indicated a more prominent role of Vav1 than DOCK2 ,
SDF-1 transiently regulates the number and affinity of alpha(v)beta(3) receptors by prostate cancer cells to enhance their metastatic behavior by increasing adhesiveness and invasiveness. ,
under shear stress, T cells encountering apically presented CXCL12 were primed to undergo robust LFA-1-dependent transendothelial migration toward subendothelial CCL5 ,
The SDF-1/CXCR4 axis plays a critical role in regulating initial vessel formation, and may function as a morphogen during human embryonic vascular development. ,
Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4 ,
The model free analysis indicated that SDF-1alpha is rigid on the nano- to picosecond timescale with flexible termini. ,
CXCL12 expression may influence tumor progression by shaping the immune cell population infiltrating lung adenocarcinoma tumors. ,
An important factor in basal cell carcinoma invasiveness. ,
CXCR4 is differentially expressed at high levels in the peripheral blood and is down-regulated in the bone marrow in response to high levels of SDF-1. ,
We found that the carrying rate of allele CXCL12-A was higher in colon cancer patients compared with rectal cancer patients (P=0.017). Analyses by ELISA showed that CRC patients (n=63) had a lower CXCL12 plasma level compared with controls (P<0.0001). ,
additive neuropathogenic properties exerted by a proteolytically cleaved chemokine as consequences of a change in receptor specificity, culminating in neurodegeneration ,
Taken together, these data suggest that fibrocytes are involved in the pathogenesis of human lung fibrosis. ,
Mesenchymal stem/stromal cells transfected with CXCL12 might become a next generation cell/chemokine therapy for therapeutic neovascularization. ,
IL-10 promoter activity was ablated by mutating two nonpolymorphic binding sites for the AP-1 transcription factor, and in primary human T cells, SDF-1 costimulation enhances AP-1 binding to both of these sites ,
It is possible that the bcr-abl fusion gene and the SDF1 genotype for 3'A allele have important implications for the pathogenesis of CML. ,
First x-ray structure of CXC class chemokine CXCL12 in complex with glycosaminoglycans; a cluster of basic residues in the dimer interface is required for chemotaxis. ,
REVIEW of platelet-derived SDF-1 in the recruitment of progenitor cells to vascular injury areas, and its subsequent effects in atherosclerosis, vascular repair, and angiogenesis ,
structure of the refolded SDF1A monomer looks like a forefinger protruding from a closed first ,
Beta-catenin has a significant role in pancreatic cancer progression through interactions with SDF-1b. ,
Inhibition of the interaction between IL-17 from T cells and SDF-1 in fibroblast-like synoviocytes may provide a new therapeutic approach in rheumatoid arthritis. ,
NF-kappaB is involved in the repression of Tac1 at higher levels of SDF-1alpha in MCF12A. These results provide insights on the behavior of breast cancer cells as they traverse across gradient changes of SDF-1alpha. ,
These results indicated that the activation of CXCR4 and its signaling pathways (MEK1/2 and Akt) are essential for CXCL12-induced cholangiocarcinoma cell invasion. ,
Results suggest that the different C termini of CXCL12 variants may contain important molecular determinants for the observed differences in antiviral effects and other biological functions. ,
The CXCL12 ligand with its exclusive receptor CXCR4 has a pivotal role in the directional migration of cancer cells during the metastatic process. [REVIEW} ,
IL-18 has a unique role in inducing the secretion of angiogenic SDF-1alpha/CXCL12, MCP-1/CCL2, and VEGF in rheumatoid arthritis synovial tissue fibroblasts, via distinct signaling intermediates. ,
DNMT1 plays a key role in maintenance of methylation, and DNMT3B may act as an accessory DNA methyltransferase to epigenetically silence CXCL12 expression in MCF-7 and AsPC1 cells ,
CXCL12 induces MMP-13 expression in human chondrocytes. ,
CXCR4/CXCL12 signaling axis can induce angiogenesis and progression of tumors by increasing expression of vascular endothelial growth factor through the activation of PI3K/Akt pathway ,
CXCL12 may function as an autocrine and paracrine mucosal signaling network regulating the competency of the epithelial barrier to withstand injury and mediate repair following damage. ,
survival time of HIV-infected people with CCR2b-+/64I and SDF1-+/+ genotypes was significantly shorter than those of the other groups (p < 0.01), but this effect was not apparent in persons with CCR2b-+/64I alleles and SDF1-+/3'A genotypes ,
CXCL12 may play a major role in the etiology of benign proliferative disease in the context of an aging tissue microenvironment. ,
These results suggested that, in cases of oral squamous cell carcinoma, the paracrine SDF-1/CXCR4 system potentiates lymph node metastasis, but distant metastasis might require the autocrine SDF-1/CXCR4 system. ,
H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12 and plays a role in the perpetuation of allergic response. ,
CXCL12 G801A polymorphism may be a risk factor for Prostate cancer. ,
phosphoinositide 3-kinase/Akt/eNOS, but not mitogen-activated protein kinase/ERK, signal transduction pathway may be involved in SDF-1alpha mediated migration of endothelial progenitor cells ,
SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level. ,
CHROMOSOME
10,
ENTREZ_GENE_ID
6387 ,
PIR_SUMMARY
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.,
UNIGENE
Hs.522891 ,
UNIREF100_ID
UniRef100_P48061 ,
UniRef100_Q8NF00 ,
UniRef100_Q9H554 ,
PIR_NREF_ID
NF00093959,
NF00094500,
NF00137324,
NF00944201,
NF01031010,
NF01457910,
NF02305100,
UNIPROT_ID
Q5IT36_HUMAN ,
Q6ICW0_HUMAN ,
Q6ZVE9_HUMAN ,
Q8NF00_HUMAN ,
Q9H554_HUMAN ,
SDF1_HUMAN ,
CYTOBAND
10q11.1,
Download File
