Results: NIGMS Research Around the Nation

Using NMR to solve the structure of an integral membrane protein, NIGMS-funded researchers have paved the way to creating better antibiotics.

NIGMS-funded researchers have discovered that microRNAs, which help regulate genes, have been around since the earliest of animal lineages.

NIGMS pledges over $48 million over 5 years to support five Centers of Excellence in Chemical Methodologies and Library Development (CMLD).

NIGMS-funded biologists have shown that losing just one telomere can lead to many abnormalities in a cell's chromosomes.

An NIGMS-funded study shows how a protein bends DNA into tight loops to regulate gene expression.

NIGMS-funded researchers have developed a way to pair proteins with a drug that prevents proteins from being degraded.

NIGMS-funded researchers have developed a way to mass-produce an antimalarial compound. Related molecules have antibiotic properties.

NIGMS-funded researchers have clarified how cholesterol interacts with neurotransmitter receptors involved in inflammation and a range of diseases.

NIGMS-funded researchers are developing new tools based on mass spectrometry to visualize things like tissue slices or organisms in biofilms.

A new window onto the world of protein structure has been opened with the launch of the NIGMS-funded PSI-Nature Structural Genomics Knowledgebase.

A study supported in part by NIGMS has discovered master controllers of a gene critical to mammalian development.

NIGMS-funded researchers have traced the biochemical processes that enable alternative proteins to be made from some of the same genes.

NIGMS-funded researchers have discovered evidence of cross talk between the nervous system and the immune system in roundworms.

NIGMS-funded biophysicists have discovered that apoptosis can exert substantial mechanical force on surrounding cells.

Researchers supported in part by NIGMS have determined how an enzyme that stitches important molecular adjustments onto proteins regulates its own function.

NIGMS-funded researchers have discovered genes in planaria flatworms that are also used in mammalian stem cell regulatory pathways.

NIGMS-funded researchers transformed human skin cells into pluripotent stem cells and then to cells that can make the hormone insulin.

NIGMS-funded researchers have modified a honeybee venom toxin to use it as a tool to study ion channels that control heart rate and salt recycling.

NIGMS-funded researchers are calling into question current treatment guidelines for high blood pressure with a study about the benefits of combining drugs.

Two long-time NIGMS grantees, Victor R. Ambros, Ph.D., and Gary B. Ruvkun, Ph.D., have received the 2008 Lasker Award for Basic Medical Research.

Biologists funded by NIGMS have identified genes that permit plants to grow in spurts at night.

NIGMS-funded researchers have used synthetic molecules to mark the DNA of planarians, a kind of regenerating worm that could serve as a model for stem cell biology.

NIGMS-funded researchers have discovered intriguing details about how an enzyme may have evolved.

NIGMS funds the Chicago Center for Systems Biology as part of its national program to study complex biological systems.

An NIGMS-funded team has found that metabolic networks are evolved to handle potentially harmful changes like gene deletions and mutations.

Scientists have determined the structure of a human membrane protein involved in metabolism and the self-destruction of cells.

NIGMS-funded chemists are using light bulbs to propel organic chemical reactions that are efficient, versatile, and environmentally benign.

NIGMS and three other NIH components have awarded $42.2 million to fund 38 exceptionally innovative research projects as part of a new program called EUREKA (for Exceptional, Unconventional Research Enabling Knowledge Acceleration).

NIGMS-funded researchers have caught in action one of the tools mammalian cells use to maintain the pattern of methylation in DNA.

NIGMS-funded researchers have found that protein motions appear to be more restricted and controlled than many expected.

NIGMS-funded researchers are asking why all animals sleep and speculate that sleep gives synapses a chance to slow down.

An NIGMS-funded collaboration has revealed a key binding pocket for flu infection. Disrupting the interaction could treat flu.

NIGMS-funded researchers have found that cancer cells in rigid surroundings are more invasive, perhaps explaining why breast cancer is more aggressive in some women.

Researchers funded in part by NIGMS have found a potential new way to stop bacteria that cause digestive problems.

An NIGMS-supported study found an apparent age bias in the treatment of elderly trauma patients.

An NIGMS-funded study challenges entrenched ideas about the working of catalysts and suggests a way to design new ones.

NIGMS-funded chemists are developing techniques to reveal the structures of membrane proteins using NMR.

Working in mice, a team supported by NIGMS has found a way to amplify the signals that tell precancerous cells to die.

NIGMS-supported researchers have developed a novel way to churn out large quantities of drugs, including antibiotics and morphine, in yeast.

NIGMS-supported researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans.

A team funded by the NIGMS has developed a user-friendly, interactive database, granting unprecedented access to information on genes involved in cell migration. 

A team of NIGMS-supported researchers has devised a new method that enables the rapid and large-scale study of E. coli genes.

NIGMS-funded researchers have developed a chemical probe that can detect the poison ricin, highlighting its damage to the body's protein-making machinery.

NIGMS-funded researchers have detailed the role of a newly discovered protein important to controlling cell division.

NIGMS-funded biologists have discovered a way that worms can sense light, pointing to a tool for understanding how nerves communicate.

University of Georgia researcher Stephen Dalton will lead a new research program focused on understanding the unique properties of embryonic stem cells.

NIGMS-funded computational biologists have developed a publicly available tool that integrates diverse data about the genome.

NIGMS has funded three new research programs aimed at uncovering the basic biology of human embryonic stem cells.

University of Wisconsin researcher James Thomson has been awarded an NIGMS grant to pursue a research program that addresses some of the most fundamental questions about stem cells.

An NIGMS-funded study shows that levels of the protein interleukin-8 in the blood are linked to children's risk for death from septic shock.

NIGMS-funded researchers have discovered a new mechanism in much-studied yeast cells that allows them to focus on consuming their favorite sugar.

An NIGMS-funded study discovered how fruit flies sense small differences in temperature.

An NIGMS-funded study has identified a new pathway that responds to DNA damage.

NIGMS-funded researchers have created a robust way to induce specific genome modifications in many types of cells.

NIGMS-funded researchers have discovered that a protein that regulates circadian rhythms works with a protein linked to aging to modulate energy use.

An NIGMS-funded mathematician is helping integrate engineering concepts like artificial intelligence into computational descriptions of cells.

NIGMS-funded researchers have discovered that p53, long known for its role in cancer, appears to be involved in skin color and anemia too.

NIGMS-funded biologists have shown that testis cells carrying a mutation for Apert's syndrome have a survival advantage.

NIGMS-funded biologists have found a link between DNA sequence palindromes and replication delays, which can trigger chromosome breaks.

An NIGMS-funded team has compiled a "parts list" for mitochondria, the cell's powerhouses, enhancing understanding of mitochondrial biology and disease.

An NIGMS-funded study used unique methods to study how ion channels respond to voltage changes to open and close.

NIGMS-funded researchers have discovered that molecular motors in the cell work by detecting minor changes in force.

NIGMS-funded biologists have demonstrated a rapid way to identify host factors needed for a virus to infect a cell.

A 12-year effort funded by NIGMS sheds light on how microbes produce carbon dioxide and methane, offering insights for improving industrial processes.

NIGMS-funded researchers have discovered that RNA can interact with the non-coding part of a gene, apparently to regulate when it's turned on.

Looking to prepare for a possible outbreak of drug-resistant avian flu, NIGMS-funded researchers have identified more than two dozen new candidate drugs.

A half century after the structure of myoglobin was solved, NIGMS-funded researchers discovered exactly how oxygen moves in the protein.

NIGMS-funded researchers have discovered a previously unknown checkpoint that helps cells divide only when they're ready.

NIGMS-funded researchers have discovered a self-organizing system that ensures accurate cell division.

Researchers funded in part by NIH have discovered a protein they named Ronin that keeps embryonic stem cells undifferentiated.

A new type of probe can be used to see thousands of interactions between proteins in a living cell, report NIGMS-funded researchers.

NIGMS-funded researchers have discovered that high levels of a starvation hormone stunt the growth of mice.

NIGMS-funded researchers have found that human cells can shift tRNAs into their mitochondria.

NIGMS-funded researchers have discovered that DNA is coiled into a highly distorted structure under tremendous pressure in a virus shell.

A computer-based method of analyzing cell activity is able to predict antitumor activity of naturally occurring metabolites, report NIGMS-funded researchers.

NIGMS-funded researchers have identified a protein that allows some malaria-carrying mosquitoes to resist the pesticide DDT.

NIGMS-funded researchers have discovered a compound that decreases the fluid secretion caused by bacteria that trigger diarrhea.

A team of NIGMS-supported researchers has figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment.

NIGMS-supported chemists have discovered an inexpensive, clean and quick way to prepare amines, compounds that are used widely in industry.

NIGMS-supported researchers have begun to pry open the lid on the inner workings of a molecule called TRiC that helps proteins fold.

NIGMS-supported scientists have shown that cells starved of iron shut down the iron-dependent, energy-making pathway and switch to a less efficient pathway that burns more sugar.

NIGMS-supported researchers have discovered new details of how the cell's major transcriptional enzyme, RNA polymerase II, functions with such exquisite precision.

NIGMS-supported researchers are the first to observe the dynamic, ratchet-like movements of single ribosomal molecules in the act of building proteins from genetic blueprints.