BLASTP 2.0.8 [Jan-05-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= YDL182W LYS20, Chr IV from 133438-134724 (428 letters) Database: nr 361,503 sequences; 110,384,460 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|1351812|sp|P48570|HOSC_YEAST HOMOCITRATE SYNTHASE, CYTOSOLIC... 841 0.0 gi|2492788|sp|Q12122|HOSM_YEAST PROBABLE HOMOCITRATE SYNTHASE, ... 756 0.0 gi|2492787|sp|Q12726|HOSM_YARLI HOMOCITRATE SYNTHASE, MITOCHOND... 695 0.0 gi|4165570|emb|CAA11503| (AJ223630) homocitrate synthase [Penic... 611 e-174 gi|1061257|emb|CAA91564| (Z67750) putative protein [Saccharomyc... 515 e-145 gi|3724367|gnl|PID|d1034757 (AB018379) homocitrate synthase [Th... 389 e-107 gi|2492794|sp|Q58595|YB95_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMO... 220 2e-56 gi|2492795|sp|Q58787|YD92_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMO... 206 2e-52 gi|2649641 (AE001038) 2-isopropylmalate synthase (leuA-1) [Arch... 204 1e-51 gi|2492793|sp|Q57926|Y503_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMO... 200 1e-50 gi|2650424 (AE001091) 2-isopropylmalate synthase (leuA-2) [Arch... 200 2e-50 gi|2622757 (AE000922) 2-isopropylmalate synthase [Methanobacter... 198 5e-50 gi|2622597 (AE000909) isopropylmalate synthase [Methanobacteriu... 190 1e-47 gi|3258158|gnl|PID|d1031784 (AP000007) 361aa long hypothetical ... 189 2e-47 gi|2621811 (AE000851) 2-isopropylmalate synthase [Methanobacter... 180 2e-44 gi|3282740 (AF041837) 2-isopropylmalate synthase [Buchnera aphi... 159 3e-38 gi|3282732 (AF041836) isopropylmalate synthase [Buchnera aphidi... 158 6e-38 gi|1346443|sp|P48571|LEU1_BUCAP 2-ISOPROPYLMALATE SYNTHASE (ALP... 156 3e-37 gi|2492792|sp|Q39891|NO56_SOYBN LATE NODULIN 56 (N-56) >gi|5322... 153 1e-36 gi|1346444|sp|P48576|LEU1_SYNY3 2-ISOPROPYLMALATE SYNTHASE (ALP... 150 1e-35 gi|2492785|sp|P94907|LEU1_MICAE 2-ISOPROPYLMALATE SYNTHASE (ALP... 149 4e-35 gi|128322|sp|P05342|NIFV_AZOVI HOMOCITRATE SYNTHASE >gi|420863|... 148 8e-35 gi|1170769|sp|P43861|LEU1_HAEIN 2-ISOPROPYLMALATE SYNTHASE (ALP... 148 8e-35 gi|1074945|pir||E64106 isopropylmalate synthase (leuA) homolog ... 148 8e-35 gi|400182|sp|Q02141|LEU1_LACLA 2-ISOPROPYLMALATE SYNTHASE (ALPH... 147 1e-34 gi|2565151 (U92974) LeuA [Lactococcus lactis] 147 1e-34 gi|1346442|sp|P48575|LEU1_ANASP 2-ISOPROPYLMALATE SYNTHASE (ALP... 146 2e-34 gi|142398 (M17349) nifV protein [Azotobacter vinelandii] 145 6e-34 gi|2492784|sp|P94565|LEU1_BACSU 2-ISOPROPYLMALATE SYNTHASE (ALP... 143 3e-33 gi|482064|pir||S40588 hypothetical protein - Escherichia coli >... 141 6e-33 gi|2983027 (AE000685) 2-isopropylmalate synthase [Aquifex aeoli... 141 8e-33 gi|2213882 (AF004165) 2-isopropylmalate synthase [Lycopersicon ... 140 1e-32 gi|2506169|sp|P09151|LEU1_ECOLI 2-ISOPROPYLMALATE SYNTHASE (ALP... 140 1e-32 gi|2984301 (AE000772) 2-isopropylmalate synthase [Aquifex aeoli... 139 3e-32 gi|266631|sp|Q00853|NIVA_CLOPA HOMOCITRATE SYNTHASE, ALPHA SUBU... 133 2e-30 gi|2213884 (AF004166) 2-isopropylmalate synthase [Lycopersicon ... 131 9e-30 gi|78954|pir||S02508 homocitrate synthase (EC 4.1.3.21) - Klebs... 128 6e-29 gi|2492791|sp|Q47884|NIFV_FRAAL HOMOCITRATE SYNTHASE >gi|125602... 128 6e-29 gi|266629|sp|Q01181|NIFV_RHOSH HOMOCITRATE SYNTHASE >gi|282178|... 127 1e-28 gi|128323|sp|P05345|NIFV_KLEPN HOMOCITRATE SYNTHASE >gi|479601|... 127 1e-28 gi|480804|pir||S37297 nifV protein - Klebsiella pneumoniae >gi|... 124 9e-28 gi|128321|sp|P23122|NIFV_AZOCH HOMOCITRATE SYNTHASE >gi|280010|... 123 2e-27 gi|585559|sp|Q07179|NIFV_RHOCA HOMOCITRATE SYNTHASE >gi|486695|... 123 3e-27 gi|2492789|sp|Q44290|NIFV_ANASP HOMOCITRATE SYNTHASE >gi|148787... 120 1e-26 gi|1709287|sp|P54610|NIFV_FRASP HOMOCITRATE SYNTHASE >gi|128003... 120 2e-26 gi|2492790|sp|Q52070|NIFV_ENTAG HOMOCITRATE SYNTHASE >gi|148012... 119 3e-26 gi|3355677|emb|CAA19977| (AL031124) putative lyase [Streptomyce... 116 3e-25 gi|126191|sp|P15875|LEU1_SALTY 2-ISOPROPYLMALATE SYNTHASE (ALPH... 111 7e-24 gi|1653449|gnl|PID|d1019096 (D90913) alpha-isopropylmalate synt... 104 9e-22 gi|1597740 (U26427) nifV [Azospirillum brasilense] 104 1e-21 gi|2239049|emb|CAA72697| (Y11966) 2-isopropylmalate synthase [B... 101 1e-20 gi|2492786|sp|Q56216|LEU1_THETH 2-ISOPROPYLMALATE SYNTHASE (ALP... 85 1e-15 gi|1709223|sp|P51017|NAHM_PSEPU 4-HYDROXY-2-OXOVALERATE ALDOLAS... 57 2e-07 gi|4104771 (AF039534) 2-oxo-4-hydroxypentanoate aldolase [Pseud... 55 7e-07 gi|2266426|emb|CAA74217| (Y13917) yngG [Bacillus subtilis] >gi|... 54 2e-06 gi|2822273 (AF006691) 4-hydroxy-2-oxovalerate aldolase [Pseudom... 53 3e-06 gi|2104392|emb|CAB08693| (Z95390) mhpE [Mycobacterium tuberculo... 53 3e-06 gi|2498245|sp|Q51983|CMTG_PSEPU 4-HYDROXY-2-OXOVALERATE ALDOLAS... 53 3e-06 gi|2339989|emb|CAB11339| (Z98682) putative pyruvate carboxylase... 50 2e-05 gi|2633857|emb|CAB13359| (Z99111) pyruvate carboxylase [Bacillu... 50 2e-05 gi|3426048 (AC005168) putative hydroxymethylglutaryl-CoA lyase ... 50 2e-05 gi|99030|pir||S20683 phosphinomethylmalic acid synthase - Strep... 50 4e-05 gi|1762117 (U41280) 3-hydroxy-3-methylglutaryl-CoA lyase [Rhodo... 50 4e-05 gi|3257245|gnl|PID|d1030871 (AP000003) 571aa long hypothetical ... 49 7e-05 gi|2627157|gnl|PID|d1024439 (AB008831) 4-hydroxy-2-oxovalerate ... 48 9e-05 gi|1732457|gnl|PID|d1010339 (D63377) 4-hydroxy-2-oxovalerate al... 48 1e-04 gi|1705497|sp|P51014|BPHF_PSES1 4-HYDROXY-2-OXOVALERATE ALDOLAS... 48 1e-04 gi|3130042|emb|CAA19019| (AL023534) 2-isopropylmalate synthase ... 47 2e-04 gi|3560136|emb|CAA20723| (AL031534) 2-isopropylmalate synthase.... 47 2e-04 gi|2129173|pir||F64453 oxaloacetate decarboxylase (EC 4.1.1.3) ... 47 3e-04 gi|127562|sp|P13703|HMGL_PSEMV HYDROXYMETHYLGLUTARYL-COA LYASE ... 46 3e-04 gi|1705498|sp|P51015|BPHI_PSESP 4-HYDROXY-2-OXOVALERATE ALDOLAS... 46 4e-04 gi|1389647|gnl|PID|d1013571 (D85853) 4-hydroxy-2-oxovalerate al... 46 4e-04 gi|3322313 (AE001190) oxaloacetate decarboxylase, subunit alpha... 46 6e-04 gi|2127407|pir||I40725 2-isopropylmalate synthase (EC 4.1.3.12)... 45 8e-04 gi|1170768|sp|P42455|LEU1_CORGL 2-ISOPROPYLMALATE SYNTHASE (ALP... 45 8e-04 gi|1695643|gnl|PID|d1011901 (D78170) pyruvate carboxylase [Schi... 45 8e-04 >gi|1351812|sp|P48570|HOSC_YEAST HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME >gi|2131289|pir||S58735 homocitrate synthase homolog YDL182w - yeast (Saccharomyces cerevisiae) >gi|1004312|emb|CAA58264| (X83276) D1298 [Saccharomyces cerevisiae] >gi|1431295|emb|CAA98757| (Z74230) ORF YDL182w [Saccharomyces cerevisiae] Length = 428 Score = 841 bits (2149), Expect = 0.0 Identities = 420/428 (98%), Positives = 420/428 (98%) Query: 1 MTAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDY 60 MTAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDY Sbjct: 1 MTAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDY 60 Query: 61 IELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFL 120 IELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVET IGTSKFL Sbjct: 61 IELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETGVDGVDVVIGTSKFL 120 Query: 121 RQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRV 180 RQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRV Sbjct: 121 RQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRV 180 Query: 181 GIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVL 240 GIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVL Sbjct: 181 GIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVL 240 Query: 241 GIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFC 300 GIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFC Sbjct: 241 GIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFC 300 Query: 301 AFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDD 360 AFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDD Sbjct: 301 AFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDD 360 Query: 361 QIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPA 420 QIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPA Sbjct: 361 QIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPA 420 Query: 421 AKRTKPSA 428 AKRTKPSA Sbjct: 421 AKRTKPSA 428 >gi|2492788|sp|Q12122|HOSM_YEAST PROBABLE HOMOCITRATE SYNTHASE, MITOCHONDRIAL ISOZYME PRECURSOR >gi|2131288|pir||S67674 homocitrate synthase homolog YDL131w - yeast (Saccharomyces cerevisiae) >gi|1419231|emb|CAA65629| (X96876) putative ORF [Saccharomyces cerevisiae] >gi|1431199|emb|CAA98700| (Z74179) ORF YDL131w [Saccharomyces cerevisiae] Length = 440 Score = 756 bits (1931), Expect = 0.0 Identities = 379/419 (90%), Positives = 389/419 (92%), Gaps = 2/419 (0%) Query: 7 NPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSP 66 NPY P DYLSNV NFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSP Sbjct: 21 NPYGPNPADYLSNVKNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSP 80 Query: 67 VASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHG 126 VASEQSRKDCEAICKLGLKAKILTHIRCHMDDA+VAVET IGTSKFLRQYSHG Sbjct: 81 VASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSKFLRQYSHG 140 Query: 127 KDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTV 186 KDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTV Sbjct: 141 KDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTV 200 Query: 187 GCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERN 246 GCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERN Sbjct: 201 GCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERN 260 Query: 247 GITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKA 306 GITPLGGLMARMIVAAPDYV+SKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKA Sbjct: 261 GITPLGGLMARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKA 320 Query: 307 GIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVT 366 GIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIK+RVDQLNLNLTDDQIKEVT Sbjct: 321 GIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVT 380 Query: 367 AKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPAAKRTK 425 AKIKKLGDVR LNIDDVDSIIK+FHAE+STP L NK D D +++ +K+ K Sbjct: 381 AKIKKLGDVRPLNIDDVDSIIKDFHAELSTP--LLKPVNKGTDDDNIDISNGHVSKKAK 437 >gi|2492787|sp|Q12726|HOSM_YARLI HOMOCITRATE SYNTHASE, MITOCHONDRIAL ISOZYME PRECURSOR >gi|1246864|emb|CAA88928| (Z49114) homocitrate synthase (acetyl-coenzyme A:2-Ketoglutarate C-acetyltransferase) [Yarrowia lipolytica] Length = 446 Score = 695 bits (1774), Expect = 0.0 Identities = 349/425 (82%), Positives = 376/425 (88%), Gaps = 9/425 (2%) Query: 2 TAAKPNPYAAKPGDYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYI 61 T + NPY A P D+LSNV+ FQLI+STLREGEQFA+AFFDTE KIEIA+ALDDFGVDYI Sbjct: 27 TGEQTNPYGANPADFLSNVSKFQLIESTLREGEQFASAFFDTETKIEIAKALDDFGVDYI 86 Query: 62 ELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLR 121 ELTSP ASEQSR DCEAICKLGLKAKILTHIRCHMDDA++AV T IGTS+FLR Sbjct: 87 ELTSPAASEQSRSDCEAICKLGLKAKILTHIRCHMDDARLAVSTGVDGVDVVIGTSQFLR 146 Query: 122 QYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVG 181 QYSHGKDMNYIA+SAVEVIEFVKS GIEIRFSSEDSFRSDLVDLLNIY+TVDKIGVNRVG Sbjct: 147 QYSHGKDMNYIAQSAVEVIEFVKSHGIEIRFSSEDSFRSDLVDLLNIYRTVDKIGVNRVG 206 Query: 182 IADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLG 241 IADTVGCANPRQVYEL+RTLKSVVSCDIECHFHNDTGCAIANAYTALE GA LIDVSVLG Sbjct: 207 IADTVGCANPRQVYELVRTLKSVVSCDIECHFHNDTGCAIANAYTALEAGANLIDVSVLG 266 Query: 242 IGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCA 301 IGERNGIT LGGLMARMI A DYV SKYKLHK+RD+ENLVADAV+VNIPFNNPITGFCA Sbjct: 267 IGERNGITSLGGLMARMIAADRDYVLSKYKLHKLRDLENLVADAVQVNIPFNNPITGFCA 326 Query: 302 FTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQ 361 FTHKAGIHAKAILANPSTYEIL+P DFG+ RYIHFANRLTGWNAIK+RVDQLNL+LTD Q Sbjct: 327 FTHKAGIHAKAILANPSTYEILNPADFGLTRYIHFANRLTGWNAIKSRVDQLNLHLTDAQ 386 Query: 362 IKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEV-STPQVLSAKKNKKNDSDVPELATIPA 420 K+VTAKIKKLGDVRSLNIDDVDSII+ FHA+V STP V + ++ P + PA Sbjct: 387 CKDVTAKIKKLGDVRSLNIDDVDSIIREFHADVTSTPTVAA--------TEGPAVEDEPA 438 Query: 421 AKRTK 425 AK+ K Sbjct: 439 AKKAK 443 >gi|4165570|emb|CAA11503| (AJ223630) homocitrate synthase [Penicillium chrysogenum] Length = 474 Score = 611 bits (1558), Expect = e-174 Identities = 298/396 (75%), Positives = 338/396 (85%), Gaps = 2/396 (0%) Query: 3 AAKPNPYAAKPG--DYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDY 60 +A NPY G D+LSNV+ FQ+I+STLREGEQFANAFFDT KKIEIA+ALDDFGVDY Sbjct: 45 SASRNPYGHDAGVTDFLSNVSRFQIIESTLREGEQFANAFFDTAKKIEIAKALDDFGVDY 104 Query: 61 IELTSPVASEQSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFL 120 IELTSP ASEQSR DCEAICKLGLKAKILTHIRCHMDDA++AVET IGTS +L Sbjct: 105 IELTSPCASEQSRADCEAICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSYL 164 Query: 121 RQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRV 180 R++SHGKDM YI +A+EVIEFVKSKGIEIRFSSEDSFRSDLVDLL+IY VDK+GVNRV Sbjct: 165 REHSHGKDMTYIKNAAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLSIYSAVDKVGVNRV 224 Query: 181 GIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVL 240 GIADTVGCA+PRQVYEL+R L+ VV CDIE HFHNDTGCAIANA+ ALE GA ID SVL Sbjct: 225 GIADTVGCASPRQVYELVRVLRGVVGCDIETHFHNDTGCAIANAFCALEAGATHIDTSVL 284 Query: 241 GIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFC 300 GIGERNGITPLGGLMARM+VA +YVKSKYKL K+++IE+LVA+AVEVNIPFNN ITGFC Sbjct: 285 GIGERNGITPLGGLMARMMVADREYVKSKYKLEKLKEIEDLVAEAVEVNIPFNNYITGFC 344 Query: 301 AFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDD 360 AFTHKAGIHAKAIL NPSTYEI++P DFGM RY+HFA+RLTGWNAIK+R QL L +TD Sbjct: 345 AFTHKAGIHAKAILNNPSTYEIINPADFGMSRYVHFASRLTGWNAIKSRAQQLKLEMTDT 404 Query: 361 QIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVST 396 Q KE TAKIK + D+R + +DD DSII+ +H + + Sbjct: 405 QYKECTAKIKAMADIRPIAVDDADSIIRAYHRNLKS 440 >gi|1061257|emb|CAA91564| (Z67750) putative protein [Saccharomyces cerevisiae] >gi|1903292|emb|CAA98756| (Z74229) ORF YDL182w [Saccharomyces cerevisiae] Length = 254 Score = 515 bits (1312), Expect = e-145 Identities = 254/254 (100%), Positives = 254/254 (100%) Query: 175 IGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARL 234 IGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARL Sbjct: 1 IGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARL 60 Query: 235 IDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNN 294 IDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNN Sbjct: 61 IDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNN 120 Query: 295 PITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLN 354 PITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLN Sbjct: 121 PITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLN 180 Query: 355 LNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPE 414 LNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPE Sbjct: 181 LNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPE 240 Query: 415 LATIPAAKRTKPSA 428 LATIPAAKRTKPSA Sbjct: 241 LATIPAAKRTKPSA 254 >gi|3724367|gnl|PID|d1034757 (AB018379) homocitrate synthase [Thermus thermophilus] Length = 376 Score = 389 bits (988), Expect = e-107 Identities = 199/375 (53%), Positives = 267/375 (71%), Gaps = 6/375 (1%) Query: 20 VNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAI 79 + +++IDSTLREGEQF A F T+ K+EIA+ALD+FG++YIE+T+PVAS QSRKD E + Sbjct: 1 MREWKIIDSTLREGEQFEKANFSTQDKVEIAKALDEFGIEYIEVTTPVASPQSRKDAEVL 60 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEV 139 LGLKAK++THI+C +D AKVAVET GTSK+LR HG+D+ I + A EV Sbjct: 61 ASLGLKAKVVTHIQCRLDAAKVAVETGVQGIDLLFGTSKYLRA-PHGRDIPRIIEEAKEV 119 Query: 140 IEFVKSKG--IEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYEL 197 I +++ +E+RFS+ED+FRS+ DLL +Y+ V V+RVG+ADTVG A PRQVY L Sbjct: 120 IAYIREAAPHVEVRFSAEDTFRSEEQDLLAVYEAVAPY-VDRVGLADTVGVATPRQVYAL 178 Query: 198 IRTLKSVVS--CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLM 255 +R ++ VV DIE H HNDTGCAIANAY A+E GA +D ++LGIGERNGITPLGG + Sbjct: 179 VREVRRVVGPRVDIEFHGHNDTGCAIANAYEAIEAGATHVDTTILGIGERNGITPLGGFL 238 Query: 256 ARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 315 ARM P+YV+ KYKL + +++ +VA V V IPFNN ITG AF+HKAG+H KAI Sbjct: 239 ARMYTLQPEYVRRKYKLEMLPELDRMVARMVGVEIPFNNYITGETAFSHKAGMHLKAIYI 298 Query: 316 NPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDV 375 NP YE P FG+KR + A+RLTG +AIKAR ++L L+ ++++ VT IK L D Sbjct: 299 NPEAYEPYPPEVFGVKRKLIIASRLTGRHAIKARAEELGLHYGEEELHRVTQHIKALADR 358 Query: 376 RSLNIDDVDSIIKNF 390 L ++++D I++ + Sbjct: 359 GQLTLEELDRILREW 373 >gi|2492794|sp|Q58595|YB95_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ1195 >gi|2127714|pir||B64449 2-isopropylmalate synthase (EC 4.1.3.12) - Methanococcus jannaschii >gi|1591824 (U67561) 2-isopropylmalate synthase (leuA) [Methanococcus jannaschii] Length = 518 Score = 220 bits (554), Expect = 2e-56 Identities = 136/381 (35%), Positives = 204/381 (52%), Gaps = 11/381 (2%) Query: 17 LSNVN---NFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSR 73 L N+N + D+TLR+GEQ E+KI+IA LDD GVD IE PV+S + Sbjct: 15 LENLNIPDRVYIFDTTLRDGEQTPGVSLTPEEKIDIAIKLDDLGVDVIEAGFPVSSLGEQ 74 Query: 74 KDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIA 133 + + IC L L A+I R D VA++ I TS R+Y K I Sbjct: 75 EAIKKICSLNLDAEICGLARAVKKDIDVAIDCGVDRIHTFIATSPLHRKYKLKKSKEEII 134 Query: 134 KSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQ 193 AV+ IE++K GI + FS+ED+ R+++ L+ +YK G + + + DTVG PR Sbjct: 135 DIAVDAIEYIKEHGIRVEFSAEDATRTEIDYLIEVYKKAVDAGADIINVPDTVGVMIPRA 194 Query: 194 VYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGG 253 +Y LI LK + I H HND G A+AN+ A+E GA + ++ G+GER G L Sbjct: 195 MYYLINELKKEIKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTINGLGERGGNAALEE 254 Query: 254 LMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAI 313 ++ M + + VK+ K K+ +I LV+ E+ + N I G AF H++GIHA + Sbjct: 255 VV--MSLMSIYGVKTNIKTQKLYEISQLVSKYTEIKVQPNKAIVGENAFAHESGIHAHGV 312 Query: 314 LANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNL----NLTDDQIKEVTAKI 369 LA+ TYE + P G KR I + TG +AI+A++ +L + ++ DQ E+ +I Sbjct: 313 LAHALTYEPIPPELVGQKRKI-ILGKHTGTHAIEAKLKELGIEVGKDINKDQFDEIVKRI 371 Query: 370 KKLGDVRSLNID-DVDSIIKN 389 K LGD D DV++I+++ Sbjct: 372 KALGDKGKRVTDRDVEAIVED 392 >gi|2492795|sp|Q58787|YD92_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ1392 >gi|2127716|pir||G64473 2-isopropylmalate synthase (EC 4.1.3.12) - Methanococcus jannaschii >gi|1592039 (U67579) 2-isopropylmalate synthase (leuA) [Methanococcus jannaschii] Length = 491 Score = 206 bits (519), Expect = 2e-52 Identities = 116/361 (32%), Positives = 199/361 (54%), Gaps = 4/361 (1%) Query: 24 QLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLG 83 ++ D+TLR+GEQ K+EIA+ LD+ GVD IE S + S+ R+ + I K G Sbjct: 4 RIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKEG 63 Query: 84 LKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFV 143 L A+I + +R D A+E + TS +Y K + + ++A++ +E+ Sbjct: 64 LNAEICSFVRALPVDIDAALECDVDSVHLVVPTSPIHMKYKLRKTEDEVLETALKAVEYA 123 Query: 144 KSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKS 203 K G+ + S+ED+ RSD+ L+ ++ +K+G +RV + DTVG P++ EL + + Sbjct: 124 KEHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQKSQELFKKITE 183 Query: 204 VVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAP 263 V+ + H HND G A AN +A+ GGA V+V GIGER G L ++A + + Sbjct: 184 NVNLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLEEVVAALKILYG 243 Query: 264 DYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEIL 323 +K K+ K+ ++ +V+ +++ +P N I G AF H+AGIH ++ N TYE + Sbjct: 244 --YDTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGLIKNTETYEPI 301 Query: 324 DPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNIDDV 383 P G +R I + +G A+K ++D + +N++D+Q+ ++ ++K+ GD+ I D Sbjct: 302 KPEMVGNRRRI-ILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVKEFGDLGKY-ISDA 359 Query: 384 D 384 D Sbjct: 360 D 360 >gi|2649641 (AE001038) 2-isopropylmalate synthase (leuA-1) [Archaeoglobus fulgidus] Length = 489 Score = 204 bits (513), Expect = 1e-51 Identities = 124/389 (31%), Positives = 206/389 (52%), Gaps = 20/389 (5%) Query: 24 QLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLG 83 +++D+TLR+GEQ E+K+ IA ALD+ GVD IE + +ASE + + I + G Sbjct: 4 KILDTTLRDGEQTPGVSLSVEQKVMIAEALDNLGVDIIEAGTAIASEGDFQAIKEISQRG 63 Query: 84 LKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKF-LRQYSHGKDMNYIAKSAVEVIEF 142 L A+I + R +D A + +S + GKD +Y+ + +VE IE+ Sbjct: 64 LNAEICSFARIKREDIDAAADAGAESIFMVAPSSDIHINAKFPGKDRDYVIEKSVEAIEY 123 Query: 143 VKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLK 202 K +G+ + F +ED+ R+DL ++ ++K ++ +R+ ADTVG +P ++ E++R +K Sbjct: 124 AKERGLIVEFGAEDASRADLDFVIQLFKRAEEAKADRITFADTVGVLSPEKMEEIVRKIK 183 Query: 203 SVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAA 262 + V + H H+D G A AN ++ GA ++ G+GER G +V A Sbjct: 184 AKVKLPLAIHCHDDFGLATANTIFGIKAGAEEFHGTINGLGER-----AGNAAIEEVVIA 238 Query: 263 PDY---VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPST 319 +Y +K+K K ++ + LV V +P N PI G AFTH++GIH A+ + + Sbjct: 239 LEYLYGIKTKIKKERLYNTSKLVEKLSRVVVPPNKPIVGDNAFTHESGIHTSALFRDAKS 298 Query: 320 YEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLN 379 YE + P G KR I + G +++A +++L T +Q+KE+ A+IK++GD Sbjct: 299 YEPISPEVVGRKRVI-VLGKHAGRASVEAIMNELGYKATPEQMKEILARIKEIGDKGKRV 357 Query: 380 ID-DVDSIIKNFHAEVSTPQVLSAKKNKK 407 D DV +II+ VL K+ KK Sbjct: 358 TDADVRTIIET---------VLQIKREKK 377 >gi|2492793|sp|Q57926|Y503_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ0503 >gi|2127715|pir||G64362 2-isopropylmalate synthase (EC 4.1.3.12) - Methanococcus jannaschii >gi|1591206 (U67500) 2-isopropylmalate synthase (leuA) [Methanococcus jannaschii] Length = 406 Score = 200 bits (504), Expect = 1e-50 Identities = 118/367 (32%), Positives = 192/367 (52%), Gaps = 5/367 (1%) Query: 19 NVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEA 78 ++ + + D+TLR+GEQ F E+K+EIAR LD+ G+ IE P+ SE+ + Sbjct: 28 DLKDIYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKT 87 Query: 79 ICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYS-HGKDMNYIAKSAV 137 I GL A IL R D A+E I TS +Y + K ++ I + V Sbjct: 88 IANEGLNADILALCRALKKDIDKAIECDVDGIITFIATSPLHLKYKFNNKSLDEILEMGV 147 Query: 138 EVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYEL 197 E +E+ K G+ + FS+ED+ R+ + DL+ ++K ++ G +RV IADT GCA P+ + + Sbjct: 148 EAVEYAKEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSMEFI 207 Query: 198 IRTLK-SVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 +TLK ++ I H HND G A+ N+ L GGA+ + +V GIGER G L L+ Sbjct: 208 CKTLKENLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAALEELIM 267 Query: 257 RMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILAN 316 + V V L + ++ +V + + +P N PI G F H++GIH A++ N Sbjct: 268 ALTVLYD--VDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHVDAVIEN 325 Query: 317 PSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVR 376 P TYE P G+KR I + +G A+ ++ + ++ + + E+ K+K++ + Sbjct: 326 PLTYEPFLPEKIGLKRNI-LLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKVKEIREEG 384 Query: 377 SLNIDDV 383 D+V Sbjct: 385 KFITDEV 391 >gi|2650424 (AE001091) 2-isopropylmalate synthase (leuA-2) [Archaeoglobus fulgidus] Length = 503 Score = 200 bits (503), Expect = 2e-50 Identities = 121/367 (32%), Positives = 197/367 (52%), Gaps = 6/367 (1%) Query: 20 VNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAI 79 + ++ D+TLR+GEQ E KI IA+ LD GVD IE P A++ + + I Sbjct: 5 MTTIRVFDTTLRDGEQMPGVSLPLEYKIRIAKQLDKLGVDVIEAGFPSATKGEFESVKEI 64 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEV 139 L L A+I R +D A+ + TS+ +++ I + +VE Sbjct: 65 SSLSLNAEICGLARIVKEDIDAAINANVDMVHIFVPTSRIQIEHTVKMSKEEIIEKSVEC 124 Query: 140 IEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIR 199 +E++KS G++ FS+ D+ R+++ L I+K V+ V+ V + DTVG A P + YELI+ Sbjct: 125 VEYIKSHGVKCMFSAMDATRTEVEYLKQIFKAVENAKVDIVNVPDTVGVATPFKFYELIK 184 Query: 200 TLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMI 259 L+ + I+ H HND G A+AN Y A+ GA + V+V GIGER G L ++ MI Sbjct: 185 QLREHLKVPIDVHCHNDFGLAVANTYAAVMAGANEVQVTVNGIGERAGNADLAQVV--MI 242 Query: 260 VAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPST 319 + A + +K+ K + + LV V +P N+PI G AF+H++GIHA +L ST Sbjct: 243 LHAIEGIKTNIKTEHLFETSKLVERLTGVKMPPNHPIVGENAFSHESGIHAHGVLKEYST 302 Query: 320 YE--ILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRS 377 +E ++ P G KR I + G IK +++ +L D+++ ++ K+K++GD + Sbjct: 303 FEPGVVTPEMVGHKRRI-VIGKHAGRYQIKKILEEAGYHLDDEKLNQIFEKVKEMGD-KG 360 Query: 378 LNIDDVD 384 + D+D Sbjct: 361 KRVTDLD 367 >gi|2622757 (AE000922) 2-isopropylmalate synthase [Methanobacterium thermoautotrophicum] Length = 391 Score = 198 bits (499), Expect = 5e-50 Identities = 118/348 (33%), Positives = 182/348 (51%), Gaps = 5/348 (1%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ TE+K+EIAR LD+ G+ IE PV SEQ R ++I GL Sbjct: 22 IYDTTLRDGEQTPGVCLGTEEKLEIARKLDELGIHQIESGFPVVSEQERVSVKSIANEGL 81 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 144 A+IL R DD A++ + TS ++ + IE+ K Sbjct: 82 NAEILALCRTKKDDIDAAIDCDVDGVITFMATSDLHLKHKLKLTREEALNVCMNSIEYAK 141 Query: 145 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 204 G+ + FS+ED+ R+DL L IY+ + G +RV IADTVG +P+ + L+R L+ Sbjct: 142 DHGLFLAFSAEDATRTDLDFLKQIYRKAENYGADRVHIADTVGAISPQGMDYLVRELRRD 201 Query: 205 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGL-MARMIVAAP 263 + DI H HND G A++N+ L G + +V GIGER G T L L MA I+ Sbjct: 202 IKVDIALHCHNDFGMALSNSIAGLLAGGTAVSTTVNGIGERAGNTSLEELIMALRIIYEV 261 Query: 264 DYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEIL 323 D + + + ++ LV + +P N PI G F H++GIH A++ P TYE Sbjct: 262 DL---GFNIGVLYELSRLVEKHTRMKVPENKPIVGRNVFRHESGIHVDAVIEEPLTYEPF 318 Query: 324 DPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKK 371 P G +R I + +G A+KA++++ +++T D++ + ++KK Sbjct: 319 LPEMIGHQRKI-VLGKHSGCRAVKAKLEEYGIDVTRDELCRIVEEVKK 365 >gi|2622597 (AE000909) isopropylmalate synthase [Methanobacterium thermoautotrophicum] Length = 505 Score = 190 bits (478), Expect = 1e-47 Identities = 116/363 (31%), Positives = 181/363 (48%), Gaps = 4/363 (1%) Query: 22 NFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICK 81 N ++ D+TLR+GEQ E+K IAR LD GVD IE P AS I + Sbjct: 15 NVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRRIVE 74 Query: 82 LGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIE 141 LGL+A I R +D A++ IGTS R+Y + I AV +E Sbjct: 75 LGLEANICGLARVLREDIDAAIDCGVDYIHTFIGTSPLHREYKLKMSPDEIIDRAVFGVE 134 Query: 142 FVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTL 201 + G+++ FS+ED+ R++ L+ +Y+ + G + + DTVG PR + L+ L Sbjct: 135 YAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAMNHLVSRL 194 Query: 202 KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVA 261 K + I H HND G A+AN+ A+E GA + +V G+GER G L ++ +I Sbjct: 195 KEELRVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAALEEVVMALITR 254 Query: 262 APDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYE 321 + + ++ +I V+ V +P N I G AF H+AGIH +L TYE Sbjct: 255 YD--LPVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIHVHGVLEKAETYE 312 Query: 322 ILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNID 381 + P G KR I + TG NA+++++ + + + ++Q + ++K+LGD + I Sbjct: 313 PITPEMVGHKRRI-VLGKHTGANALRSKLQEYGIEMKEEQFCTLYEQVKRLGD-KGKRIT 370 Query: 382 DVD 384 D D Sbjct: 371 DAD 373 >gi|3258158|gnl|PID|d1031784 (AP000007) 361aa long hypothetical 2-isopropylmalate synthase [Pyrococcus horikoshii] Length = 361 Score = 189 bits (476), Expect = 2e-47 Identities = 109/344 (31%), Positives = 182/344 (52%), Gaps = 7/344 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 ++DSTLREGEQ + E+++ IA ALD+ GVD+IE+ P S+ + I L Sbjct: 2 ILDSTLREGEQTPGVNYSPEQRLRIALALDEIGVDFIEVGHPAVSKDVFIGIKLIASQDL 61 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 144 A +L H R ++D ++ S + ++ + + IE+ K Sbjct: 62 NANLLAHSRALLEDIDYVIQADVEWVGIFFCLSNACLRKRFRMSLSQALERISKAIEYAK 121 Query: 145 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 204 G+++RF+ ED+ R++ +L + ++ V+R+ +ADT G +P + Y L++ + + Sbjct: 122 DHGLKVRFTPEDTTRTEWENLRRAIELAKELKVDRISVADTTGGTHPLRFYTLVKKVVNF 181 Query: 205 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPD 264 + H HND G A+ANA +EGGA ++D +V G+GER GI L ++ V Sbjct: 182 -GIPVNVHCHNDLGLALANAIMGIEGGATVVDATVNGLGERAGIVDLAQIVT---VLYYH 237 Query: 265 YVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 324 Y KY+L K+ +I +V++ + + N PI G AFTHKAG+H A+L +P YE L Sbjct: 238 YGVKKYRLDKLYEISRMVSEITGIALQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297 Query: 325 PHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAK 368 FG +R I + +R G + I+ + +L +N D++ +V K Sbjct: 298 AEVFGRERTI-YVDRFAGKDTIRYYLQKLGIN--DEEFVKVLLK 338 >gi|2621811 (AE000851) 2-isopropylmalate synthase [Methanobacterium thermoautotrophicum] Length = 496 Score = 180 bits (451), Expect = 2e-44 Identities = 121/407 (29%), Positives = 192/407 (46%), Gaps = 19/407 (4%) Query: 24 QLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLG 83 +++D+TLR+GEQ E+K+ IA +D G D IE S + SE R+ I G Sbjct: 4 RVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITSEG 63 Query: 84 LKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFV 143 L+A+I + R +D A+ + TS ++ K + + AV+ E+ Sbjct: 64 LRAEICSFARAVREDIDAAISCDVDSVHLVVPTSDLHLEHKLRKTREEVLEQAVDCTEYA 123 Query: 144 KSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKS 203 GI + S+EDS RSD+ L I++ + G R+ DTVG P + YE R L S Sbjct: 124 VDHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVGILTPERSYEFYRGL-S 182 Query: 204 VVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAP 263 + + H HND G A+AN+ L GA + ++ GIGER G + ++VA Sbjct: 183 ELGAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAG----NAALEEVVVALK 238 Query: 264 DY--VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYE 321 V + + + + +VA V + N I G AF H++GIHA +L TYE Sbjct: 239 SLYDVDTSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHADGVLKKAETYE 298 Query: 322 ILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNID 381 + P G R + G +A++ R+D+L + + DD++ E+ ++K LGD+ + Sbjct: 299 PITPEMVGHGRGFVMGKHI-GTHALRKRLDELGMKVADDKLMEIFRRVKTLGDMGKC-VT 356 Query: 382 DVDSIIKNFHAEVSTPQVLSAKKNKKNDSDVPELATIPAAKRTKPSA 428 DVD + VL ++K D + TI + R P+A Sbjct: 357 DVD-------LQAIAEDVLGVMEDKVVDL---QEVTIVSGNRVTPTA 393 >gi|3282740 (AF041837) 2-isopropylmalate synthase [Buchnera aphidicola] Length = 516 Score = 159 bits (398), Expect = 3e-38 Identities = 110/370 (29%), Positives = 179/370 (47%), Gaps = 17/370 (4%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA +L+ G+D IE+ P++S K + I K Sbjct: 7 IFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDIIEVGFPISSPGDFKSVQTISKKIK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGKDMNYIAKSAVEVI 140 ++I + RC D +VA + I TS + K+ + I AV + Sbjct: 67 NSRICSLARCVEKDIEVAGDAMSSSDFFRIHIFLATSTLHMESKLRKNFDEIIDMAVSSV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ FS ED+ R+ + +L I + + K GV + I DTVG P ++ +I+ Sbjct: 127 KKALRYTDDVEFSCEDASRTTMDNLCRIVEKLIKAGVKTINIPDTVGYTIPNELSNIIKN 186 Query: 201 L--------KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG 252 L KS++S H HND G A+ N+ +A++ GAR I+ ++ GIGER G T L Sbjct: 187 LFERVPNIHKSIISV----HCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALE 242 Query: 253 GLMARMIVAAPDYVKSKYKLHK-IRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAK 311 ++ + V S +HK I +++ + IP N I G AF H +GIH Sbjct: 243 EIIMAIKVREDILGVSTNIVHKEIYRTSQIISQICNMPIPANKAIVGSNAFAHSSGIHQD 302 Query: 312 AILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKK 371 +L N YEI++P+ G+K +G A+K +D++ D I E+ + K Sbjct: 303 GVLKNRKNYEIMEPNTIGVKEVKLNLTSRSGRAAVKYYMDKMGYKDDDYDIDELYSAFLK 362 Query: 372 LGDVRSLNID 381 L D + D Sbjct: 363 LADKKGQVFD 372 >gi|3282732 (AF041836) isopropylmalate synthase [Buchnera aphidicola] Length = 518 Score = 158 bits (396), Expect = 6e-38 Identities = 109/366 (29%), Positives = 174/366 (46%), Gaps = 9/366 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA +L++ G+D IE+ P++S K + I K Sbjct: 7 IFDTTLRDGEQALQASLSVKQKLQIALSLENAGIDIIEVGFPISSPGDFKSVQTISKNIK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGKDMNYIAKSAVEVI 140 ++I + RC D A E I TS + K+ + I A+ + Sbjct: 67 NSRICSLARCLNKDIDTAAEAMSSSNTFRIHIFLATSTLHMESKLKKNFDQIIDMAISSV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ FS ED+ R+ + +L I + + K GV + I DTVG P ++ +I Sbjct: 127 KRALRYTDDVEFSCEDASRTTMDNLCRIVEQLIKAGVKTINIPDTVGYTVPNELSTIIHN 186 Query: 201 L-KSVVSCD---IECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 L K V + D I H HND G A+ N+ +A++ GAR I+ ++ GIGER G T L ++ Sbjct: 187 LFKRVPNIDQSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIM 246 Query: 257 RMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 315 + V V + K +I +++ + IP N I G AF H +GIH +L Sbjct: 247 AIKVREDILGVSTNIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQDGVLK 306 Query: 316 NPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDV 375 N YEI++P G+K +G A+K + Q+ D I E+ KL D Sbjct: 307 NRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKYYMTQMGYKECDYNIDELYTSFLKLADK 366 Query: 376 RSLNID 381 + D Sbjct: 367 KGQVFD 372 >gi|1346443|sp|P48571|LEU1_BUCAP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|899388|emb|CAA50615| (X71612) 2-isopropylmalate synthase [Buchnera aphidicola] Length = 518 Score = 156 bits (390), Expect = 3e-37 Identities = 108/366 (29%), Positives = 176/366 (47%), Gaps = 9/366 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA +L++ G+D IE+ P++S K + I K Sbjct: 7 IFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQTISKNIK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGKDMNYIAKSAVEVI 140 ++I + RC D A E I TS + K+ + I A+ + Sbjct: 67 NSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIIDMAITSV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ FS ED+ R+ + +L I + + GV + I DTVG P ++ +I Sbjct: 127 KRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNELSSIIHN 186 Query: 201 L-KSVVSCD---IECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 L + V + D I H HND G A+ N+ +A++ GAR I+ ++ GIGER G T L ++ Sbjct: 187 LFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVII 246 Query: 257 RMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 315 + V V +K K +I +++ + IP N I G AF H +GIH +L Sbjct: 247 AIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQDGVLK 306 Query: 316 NPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDV 375 N YEI++P G+K +G A+K + ++ D +I E+ A KL D Sbjct: 307 NRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDELYASFLKLADK 366 Query: 376 RSLNID 381 + D Sbjct: 367 KGQVFD 372 >gi|2492792|sp|Q39891|NO56_SOYBN LATE NODULIN 56 (N-56) >gi|532290|gnl|PID|d1007790 (D38015) soybean late nodulin [Glycine max] Length = 565 Score = 153 bits (384), Expect = 1e-36 Identities = 113/405 (27%), Positives = 194/405 (47%), Gaps = 26/405 (6%) Query: 15 DYLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQ--- 71 +++ + + +++D+TLR+GEQ A ++K++IAR L GVD I+ P AS Sbjct: 25 NHIPDSSYVRILDTTLRDGEQSPGATMTAKEKLDIARQLVKLGVDIIQPGFPSASNSDFM 84 Query: 72 -----SRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQ 122 +++ A+ G I RC D A E I TS + Sbjct: 85 AVKMIAQEVGNAVDDDGYVPVIAGFCRCVEKDISTAWEAVKYAKRPRLCTSIATSPIHME 144 Query: 123 YSHGKDMNYIAKSAVEVIEFVKSKGI-EIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVG 181 + K + + + A ++++F +S G +I+F +ED+ RSD L I V + G V Sbjct: 145 HKLRKSKDQVIQIARDMVKFARSLGCNDIQFGAEDATRSDREFLYEILGVVIEAGATTVN 204 Query: 182 IADTVGCANPRQVYELIRTLKS----VVSCDIECHFHNDTGCAIANAYTALEGGARLIDV 237 IADTVG P ++ +LI +K + + I H HND G A AN GAR ++V Sbjct: 205 IADTVGIVMPLELGKLIVDIKDNTPGIANVIISTHCHNDLGLATANTIEGARTGARQLEV 264 Query: 238 SVLGIGERNGITPLGGLMARMIVAAPDYVKSKY---KLHKIRDIENLVADAVEVNIPFNN 294 ++ GIGER G L ++ + + Y I + +V + +++ + Sbjct: 265 TINGIGERAGNASLEEVVMALASKGDHALNGLYTRINTRHILETSKMVEEYSGMHLQPHK 324 Query: 295 PITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFA---NRLTGWNAIKARVD 351 P+ G AF H +GIH +L + TYE + P + G KR +L+G A++ R++ Sbjct: 325 PLVGANAFVHASGIHQDGMLKHKGTYETISPEEIGHKRTTRIGIVLGKLSGSQALRKRLE 384 Query: 352 QLNLNLTDDQIKEVTAKIKKLGDVRSLNID-DVDSII--KNFHAE 393 +L +L +D++ V + K + + + + D D+ +++ K FHAE Sbjct: 385 ELGYDLKEDEVDSVFWQFKAMAEKKKVVTDVDLKALVSYKAFHAE 429 >gi|1346444|sp|P48576|LEU1_SYNY3 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|1001454|gnl|PID|d1010730 (D63999) 2-isopropylmalate synthase [Synechocystis sp.] Length = 533 Score = 150 bits (376), Expect = 1e-35 Identities = 124/434 (28%), Positives = 187/434 (42%), Gaps = 33/434 (7%) Query: 18 SNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCE 77 S V+ + D+TLR+GEQ A E+K+ IARAL GVD IE P AS D E Sbjct: 3 SPVDRILIFDTTLRDGEQSPGATLTVEEKLSIARALARLGVDIIEAGFPFASPG---DFE 59 Query: 78 AICKLGLKAK------ILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGK 127 A+ K+ I R D K A E I TS ++ K Sbjct: 60 AVQKIAQTVGTENGPVICGLARATQKDIKAAAEALKPAAKHRIHTFLATSDIHLEHKLKK 119 Query: 128 DMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVG 187 + E++ + KS +I FS ED+ RSD L + + G + I DTVG Sbjct: 120 TRAEVLAIVPEMVAYAKSLVNDIEFSPEDAGRSDPEFLYQVLEAAISAGATTINIPDTVG 179 Query: 188 CANPRQVYELIR----TLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIG 243 P + LI+ + ++ I H HND G A+AN A++ GAR ++ ++ GIG Sbjct: 180 YTTPAEYGALIKGIADNVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIG 239 Query: 244 ERNGITPLGGLMARMIV------------AAPDYVKSKYKLHKIRDIENLVADAVEVNIP 291 ER G L L+ + V A + I LV++ + + Sbjct: 240 ERAGNAALEELVMALHVRRSYFNPFLGRPADSTAPLTNIDTKHIYATSRLVSELTGMMVQ 299 Query: 292 FNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVD 351 N I G AF H++GIH +L N TYEI+D G+ +L+G NA R+ Sbjct: 300 PNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFGTRLK 359 Query: 352 QLNLNLTDDQIKEVTAKIKKLGDVRSLNID-DVDSIIKNFHAEVSTPQVLSAKKNKKNDS 410 +L +L+D ++ + K++ D R D D+++I+ + E+ P L + + Sbjct: 360 ELGFDLSDTELNNAFIRFKEVADKRKEITDWDLEAIVND---EIRQPPELFRLERVQVSC 416 Query: 411 DVPELATIPAAKRT 424 P + T RT Sbjct: 417 GEPSVPTATLTIRT 430 >gi|2492785|sp|P94907|LEU1_MICAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|1783285|gnl|PID|d1013533 (D85684) 2-isopropylmalate synthase [Microcystis aeruginosa] Length = 533 Score = 149 bits (372), Expect = 4e-35 Identities = 120/406 (29%), Positives = 187/406 (45%), Gaps = 39/406 (9%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKL-- 82 + D+TLR+GEQ A + ++K+ IARAL GVD IE P AS D EA+ K+ Sbjct: 10 IFDTTLRDGEQSPGAALNVDEKLTIARALARLGVDVIEAGFPHASPG---DFEAVQKIAG 66 Query: 83 --GLKAK---ILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGKDMNYIA 133 G +A I R D K A + I TS QY K + Sbjct: 67 SVGSEADSPIICGLARATQKDIKSAADALRPAAKPRIHTFLATSDIHLQYKLKKTRQEVL 126 Query: 134 KSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQ 193 + E++ + KS ++ FS ED+ RSD L + + G V I DTVG P + Sbjct: 127 EIVPEMVAYAKSFLNDVEFSPEDAGRSDPEFLYQVLERAIAAGATTVNIPDTVGYTTPSE 186 Query: 194 VYELIRTLKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGIT 249 LIR +K V I H H+D G A+AN A++ GAR ++ ++ GIGER G Sbjct: 187 FGALIRGIKENVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECTINGIGERAGNA 246 Query: 250 PLGGLMARMIVAAPDY-------VKSKYKLHKIRDIE-----NLVADAVEVNIPFNNPIT 297 L L+ + V + +S L KI E LV++ + + N I Sbjct: 247 SLEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLTGMIVQPNKAIV 306 Query: 298 GFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNL 357 G AF H++GIH +L + TYEI+D G+ +L+G NA ++R+ +L L Sbjct: 307 GANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTNNQIVLGKLSGRNAFRSRLQELGFEL 366 Query: 358 TDDQIKEVTAKIKKLG---------DVRSLNIDDVDSIIKNFHAEV 394 ++ ++ + K++ D+ ++ D++D++ +F E+ Sbjct: 367 SETELNNAFIQFKEMADRKKEITDRDLEAIVNDEIDTVPDHFRLEL 412 >gi|128322|sp|P05342|NIFV_AZOVI HOMOCITRATE SYNTHASE >gi|420863|pir||S29758 nifV protein - Azotobacter vinelandii >gi|142362 (M20568) homocitrate synthase (nifV) [Azotobacter vinelandii] Length = 385 Score = 148 bits (369), Expect = 8e-35 Identities = 96/346 (27%), Positives = 163/346 (46%), Gaps = 7/346 (2%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ A F+ ++KI IARAL + GV +E+ P E+ R+ AI LGL + Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGLSS 67 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 ++L R D A T + S + + +D ++ + ++ + Sbjct: 68 RLLAWCRLCDVDLAAARSTGVTMVDLSLPVSDLMLHHKLNRDRDWALREVARLVGEARMA 127 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+E+ ED+ R+DL ++ + + G R+ ADTVG P + + R L + Sbjct: 128 GLEVCLGCEDASRADLEFVVQVGEVAQAAGARRLRFADTVGVMEPFGMLDRFRFLSRRLD 187 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDY- 265 ++E H H+D G A AN A+ GGA I+ +V G+GER G + ++A + Sbjct: 188 MELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAG----NAALEECVLALKNLH 243 Query: 266 -VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 324 + + I I LV A + + + G FTH+AGIH +L + YE L+ Sbjct: 244 GIDTGIDTRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLLKHRRNYEGLN 303 Query: 325 PHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIK 370 P + G + + +G + ++ L + L D Q + + +I+ Sbjct: 304 PDELGRSHSL-VLGKHSGAHMVRNTYRDLGIELADWQSQALLGRIR 348 >gi|1170769|sp|P43861|LEU1_HAEIN 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) Length = 515 Score = 148 bits (369), Expect = 8e-35 Identities = 105/367 (28%), Positives = 172/367 (46%), Gaps = 11/367 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S+ + + I + Sbjct: 7 IFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHIK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGT----SKFLRQYSHGKDMNYIAKSAVEVI 140 A++ R D A E I T S + + + + AV + Sbjct: 67 NARVAALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAAV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ ++ FS ED+ R+ + ++ I + G V I DTVG P + +I Sbjct: 127 KRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYGNIIAQ 186 Query: 201 LKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 +++ V I H HND G A AN+ TA++ GAR I+ ++ GIGER G T L ++ Sbjct: 187 VRNCVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTSLEEVVM 246 Query: 257 RMIVAAPDY--VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAIL 314 M V D+ V + +I + +V+ + I N I G AF H +GIH +L Sbjct: 247 AMKVRQ-DFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGML 305 Query: 315 ANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGD 374 N +TYEIL P G+K+ +G A+K + + N D + ++ + KL D Sbjct: 306 KNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLDKLYDEFLKLAD 365 Query: 375 VRSLNID 381 + D Sbjct: 366 KKGQVFD 372 >gi|1074945|pir||E64106 isopropylmalate synthase (leuA) homolog - Haemophilus influenzae (strain Rd KW20) >gi|1574015 (U32779) 2-isopropylmalate synthase (leuA) [Haemophilus influenzae Rd] Length = 531 Score = 148 bits (369), Expect = 8e-35 Identities = 105/367 (28%), Positives = 172/367 (46%), Gaps = 11/367 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S+ + + I + Sbjct: 23 IFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHIK 82 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGT----SKFLRQYSHGKDMNYIAKSAVEVI 140 A++ R D A E I T S + + + + AV + Sbjct: 83 NARVAALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAAV 142 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ ++ FS ED+ R+ + ++ I + G V I DTVG P + +I Sbjct: 143 KRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYGNIIAQ 202 Query: 201 LKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 +++ V I H HND G A AN+ TA++ GAR I+ ++ GIGER G T L ++ Sbjct: 203 VRNCVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTSLEEVVM 262 Query: 257 RMIVAAPDY--VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAIL 314 M V D+ V + +I + +V+ + I N I G AF H +GIH +L Sbjct: 263 AMKVRQ-DFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGML 321 Query: 315 ANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGD 374 N +TYEIL P G+K+ +G A+K + + N D + ++ + KL D Sbjct: 322 KNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLDKLYDEFLKLAD 381 Query: 375 VRSLNID 381 + D Sbjct: 382 KKGQVFD 388 >gi|400182|sp|Q02141|LEU1_LACLA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|486724|pir||S35132 probable 2-isopropylmalate synthase (EC 4.1.3.12) - Lactococcus lactis subsp. lactis Length = 513 Score = 147 bits (368), Expect = 1e-34 Identities = 104/374 (27%), Positives = 169/374 (44%), Gaps = 10/374 (2%) Query: 20 VNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAI 79 + + D++LR+GEQ F +K+ IA+ L+ + + IE AS S + + I Sbjct: 1 MRKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQI 60 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKS 135 + RC + D AVE I TS +Y + K+ Sbjct: 61 ADSLNDTAVTALARCVISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEEVLKN 120 Query: 136 AVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVY 195 + + + + + + FS ED+ R++L LL +T G + I DTVG P + Sbjct: 121 IDKCVRYARERVEVVEFSPEDATRTELNFLLEAVQTAVDAGATYINIPDTVGYTTPEEYG 180 Query: 196 ELIRTLKSVVSCDIEC----HFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPL 251 ++ + L D E H H+D G A+AN+ A++ GA ++ +V GIGER G L Sbjct: 181 KIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAAL 240 Query: 252 GGLMARMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHA 310 + + + Y +S KL + L++ + IP N I G AF H++GIH Sbjct: 241 EEIAVALHIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFAHESGIHQ 300 Query: 311 KAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIK 370 +L N TYEI+ P G+K +L+G +A ++ +LN+ D+ + + K K Sbjct: 301 DGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLAILFEKFK 360 Query: 371 KLGDVRSLNIDDVD 384 KL D + I D D Sbjct: 361 KLAD-KKKEITDAD 373 >gi|2565151 (U92974) LeuA [Lactococcus lactis] Length = 565 Score = 147 bits (368), Expect = 1e-34 Identities = 104/374 (27%), Positives = 169/374 (44%), Gaps = 10/374 (2%) Query: 20 VNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAI 79 + + D++LR+GEQ F +K+ IA+ L+ + + IE AS S + + I Sbjct: 53 MRKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQI 112 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKS 135 + RC + D AVE I TS +Y + K+ Sbjct: 113 ADSLNDTAVTALARCVISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEEVLKN 172 Query: 136 AVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVY 195 + + + + + + FS ED+ R++L LL +T G + I DTVG P + Sbjct: 173 IDKCVRYARERVEVVEFSPEDATRTELNFLLEAVQTAVDAGATYINIPDTVGYTTPEEYG 232 Query: 196 ELIRTLKSVVSCDIEC----HFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPL 251 ++ + L D E H H+D G A+AN+ A++ GA ++ +V GIGER G L Sbjct: 233 KIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAAL 292 Query: 252 GGLMARMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHA 310 + + + Y +S KL + L++ + IP N I G AF H++GIH Sbjct: 293 EEIAVALHIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFAHESGIHQ 352 Query: 311 KAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIK 370 +L N TYEI+ P G+K +L+G +A ++ +LN+ D+ + + K K Sbjct: 353 DGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLAILFEKFK 412 Query: 371 KLGDVRSLNIDDVD 384 KL D + I D D Sbjct: 413 KLAD-KKKEITDAD 425 >gi|1346442|sp|P48575|LEU1_ANASP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|1084180|pir||S52294 2-isopropylmalate synthase (EC 4.1.3.12) - Anabaena sp. (PCC 7120) >gi|662867|emb|CAA87005| (Z46907) alpha-isopropylmalate synthase [Anabaena PCC7120] Length = 531 Score = 146 bits (366), Expect = 2e-34 Identities = 115/392 (29%), Positives = 179/392 (45%), Gaps = 30/392 (7%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A + ++K+ IA+ L GVD IE AS D EA+ K+ Sbjct: 10 IFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPG---DFEAVHKIAQ 66 Query: 85 KAK------ILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAK 134 I + R DD K A E I TS QY K + Sbjct: 67 TVGTQSGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIA 126 Query: 135 SAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQV 194 A E++ + KS ++ FS ED+ RSD L + + G + I DTVG P + Sbjct: 127 IAEEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEF 186 Query: 195 YELIRTLKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITP 250 +I+ +K V I H HND G A+AN A++ GAR ++ ++ GIGER G Sbjct: 187 GAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAA 246 Query: 251 LGGLMARMIVAA----------PDYVKSKYKLH--KIRDIENLVADAVEVNIPFNNPITG 298 L L+ M V PD ++ + +I LV++ + + N I G Sbjct: 247 LEELVMAMHVRRQYFNPFLGRHPDSEEALTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVG 306 Query: 299 FCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLT 358 AF H++GIH +L N TYEI+D G+ + +G NA + R+ +L L+ Sbjct: 307 ANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELGFELS 366 Query: 359 DDQIKEVTAKIKKLGDVRSLNID-DVDSIIKN 389 + ++ + K K++ D + D D+++I+ + Sbjct: 367 ETELNKAFVKFKEVADKKKEISDWDLEAIVND 398 >gi|142398 (M17349) nifV protein [Azotobacter vinelandii] Length = 385 Score = 145 bits (362), Expect = 6e-34 Identities = 95/346 (27%), Positives = 162/346 (46%), Gaps = 7/346 (2%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ A F+ ++KI IARAL + GV +E+ P E+ R+ AI LGL + Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGLSS 67 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 ++L R D A T + S + + +D ++ + ++ + Sbjct: 68 RLLAWCRLCDVDLAAARSTGVTMVDLSLPVSDLMLHHKLNRDRDWALREVARLVGEARMA 127 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+E+ ED+ R+DL ++ + + G + ADTVG P + + R L + Sbjct: 128 GLEVCLGCEDASRADLEFVVQVGEVAQAAGARPLRFADTVGVMEPFGMLDRFRFLSRRLD 187 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDY- 265 ++E H H+D G A AN A+ GGA I+ +V G+GER G + ++A + Sbjct: 188 MELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAG----NAALEECVLALKNLH 243 Query: 266 -VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 324 + + I I LV A + + + G FTH+AGIH +L + YE L+ Sbjct: 244 GIDTGIDTRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLLKHRRNYEGLN 303 Query: 325 PHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIK 370 P + G + + +G + ++ L + L D Q + + +I+ Sbjct: 304 PDELGRSHSL-VLGKHSGAHMVRNTYRDLGIELADWQSQALLGRIR 348 >gi|2492784|sp|P94565|LEU1_BACSU 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|1770069|emb|CAA99531| (Z75208) 2-isopropylmalate synthase [Bacillus subtilis] >gi|2635293|emb|CAB14788| (Z99118) 2-isopropylmalate synthase [Bacillus subtilis] Length = 518 Score = 143 bits (356), Expect = 3e-33 Identities = 113/425 (26%), Positives = 192/425 (44%), Gaps = 27/425 (6%) Query: 20 VNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAI 79 + D+TLR+GEQ +T++K+ IA+ L+ G D IE P +S + I Sbjct: 1 MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGDFLAVQEI 60 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKS 135 + + RC D A E I TS ++ + + Sbjct: 61 ARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIER 120 Query: 136 AVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVY 195 AV ++++ K + +++S+ED+ R++L L I + V G + + + DTVG P + Sbjct: 121 AVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGYLAPAEYG 180 Query: 196 ELIRTLKSVV----SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPL 251 + + +K V + H H+D G A+AN+ A+E GA I+ +V GIGER G L Sbjct: 181 NIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGERAGNAAL 240 Query: 252 GGLMARMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHA 310 + + Y V++ L++I+ +LV+ + +P N + G AF H++GIH Sbjct: 241 EEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQ 300 Query: 311 KAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQI-------K 363 L STYEI+ P G+ + +G +A K R+ L ++I K Sbjct: 301 DGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEEINKFFTMFK 360 Query: 364 EVTAKIKKL--GDVRSLNIDD------VDSIIKNFHAEVSTPQVLSAK---KNKKNDSDV 412 E+T K K++ D+ SL +++ + + T QV +A KN++N + Sbjct: 361 ELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHYGTSQVPTATLSLKNQENAQLI 420 Query: 413 PELAT 417 E AT Sbjct: 421 QEAAT 425 >gi|482064|pir||S40588 hypothetical protein - Escherichia coli >gi|216492|gnl|PID|d1001815 (D10483) ORF [Escherichia coli] Length = 523 Score = 141 bits (353), Expect = 6e-33 Identities = 98/366 (26%), Positives = 167/366 (44%), Gaps = 9/366 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S + + I + Sbjct: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKSAVEVI 140 +++ RC D VA E+ I TS ++ + + A+ ++ Sbjct: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ ++ FS ED+ R+ + DL + + G + I DTVG P + +I Sbjct: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 Query: 201 L----KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 L S+ I H H+D G A+ N+ A+ GAR ++ ++ GIGER G L ++ Sbjct: 187 LYERVPSIGKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 Query: 257 RMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 315 + V V + +I LV+ + IP N I G AF H +GIH +L Sbjct: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 Query: 316 NPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDV 375 N YEI+ P G+ + +G A+K R+D++ ++ + + KL D Sbjct: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 Query: 376 RSLNID 381 + D Sbjct: 367 KGQVFD 372 >gi|2983027 (AE000685) 2-isopropylmalate synthase [Aquifex aeolicus] Length = 528 Score = 141 bits (352), Expect = 8e-33 Identities = 107/366 (29%), Positives = 179/366 (48%), Gaps = 22/366 (6%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+G Q F E KI IA LDDFG+ YIE P A+ + + K+ Sbjct: 7 IYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQKAKKMNF 66 Query: 85 K-AKILTHIRCHMDDAKVA----VETXXXXXXXXI---GTSKFLR-----QYSHGKDMNY 131 K AK+ + KV+ VE+ + G S L + + +++N Sbjct: 67 KNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTLEENLNM 126 Query: 132 IAKSAVEVIEFVKSKGIEIRFSSE---DSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGC 188 I E +E++K E+ F +E D ++S+ L + + K G + V + DT G Sbjct: 127 I----YETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTNGG 182 Query: 189 ANPRQVYELIRTLKS-VVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNG 247 P ++YE+ + +K ++ H HND+ A+AN+ A+ GAR + ++ GIGER G Sbjct: 183 TLPHEIYEITKKVKERFKDANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGIGERTG 242 Query: 248 ITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAG 307 L ++ + + V + L K+ ++ N VA+ + + +P N P G AF HK G Sbjct: 243 NANLCSIIPNLQLKLGFDVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESAFAHKGG 302 Query: 308 IHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAI-KARVDQLNLNLTDDQIKEVT 366 +HA A+L N TYE ++P G KR I ++ N + K + + ++ ++K++ Sbjct: 303 VHASAVLKNAKTYEHINPELVGNKRKITVSDLAGRSNLVHKLKEFGIEIDPKSPELKKLI 362 Query: 367 AKIKKL 372 KIK+L Sbjct: 363 DKIKEL 368 >gi|2213882 (AF004165) 2-isopropylmalate synthase [Lycopersicon pennellii] Length = 589 Score = 140 bits (350), Expect = 1e-32 Identities = 110/406 (27%), Positives = 184/406 (45%), Gaps = 25/406 (6%) Query: 17 LSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDC 76 +S+ ++ D+TLR+GEQ A T++K+++AR L GVD IE P +SE + Sbjct: 42 ISDPKYVRIFDTTLRDGEQSPGATMTTKEKLDVARQLAKLGVDIIEAGFPASSEADFESV 101 Query: 77 EAIC--------KLGLKAKILTHIRCHMDDAKVAVETXXXX----XXXXIGTSKFLRQYS 124 + I + G I RC+ D A E I TS+ +Y Sbjct: 102 KLIAEEIGNNTDENGFVPVICGLSRCNKSDIDKAWEAVKYAKKPRVHTFIATSEIHMKYK 161 Query: 125 HGKDMNYIAKSAVEVIEFVKSKGIE-IRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIA 183 + + A ++ + +S G E + FS ED+ RSD L +I V K G + I Sbjct: 162 LKMSREQVVEKARSMVAYARSLGCEDVEFSPEDAGRSDREFLYDILGEVIKAGATTLNIP 221 Query: 184 DTVGCANPRQVYELIRTLKS----VVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSV 239 DTVG P + +LI +K+ + + I H ND G + AN GAR ++V++ Sbjct: 222 DTVGYTVPSEFGQLITDIKANTPGIENVIISTHCQNDLGLSTANTLAGACAGARQLEVTI 281 Query: 240 LGIGERNGITPLGGLMARMIVAAPDYVKSKY---KLHKIRDIENLVADAVEVNIPFNNPI 296 GIGER G L ++ + + Y I +V + + + + I Sbjct: 282 NGIGERAGNASLEEVVMALKCRGEQVLGGLYTGINTQHIVPSSKMVEEYSGLQVQPHKAI 341 Query: 297 TGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIH---FANRLTGWNAIKARVDQL 353 G AF H++GIH +L + TYEI+ P D G+ R +L+G +A+K+++ +L Sbjct: 342 VGANAFAHESGIHQDGMLKHKDTYEIISPDDVGLSRSNEAGIVLGKLSGRHALKSKMLEL 401 Query: 354 NLNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQV 399 ++ +++++ + K + + + D D +I EV P V Sbjct: 402 GYDIDGKELEDLFWRFKSVAEKKKKITD--DDLIALMSDEVLQPNV 445 >gi|2506169|sp|P09151|LEU1_ECOLI 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|1786261 (AE000117) 2-isopropylmalate synthase [Escherichia coli] Length = 523 Score = 140 bits (350), Expect = 1e-32 Identities = 97/366 (26%), Positives = 167/366 (45%), Gaps = 9/366 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S + + I + Sbjct: 7 IFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKSAVEVI 140 +++ RC D VA E+ I TS ++ + + A+ ++ Sbjct: 67 NSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ ++ FS ED+ R+ + DL + + G + I DTVG P + +I Sbjct: 127 KRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISG 186 Query: 201 L----KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMA 256 L ++ I H H+D G A+ N+ A+ GAR ++ ++ GIGER G L ++ Sbjct: 187 LYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIM 246 Query: 257 RMIVAAPDY-VKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 315 + V V + +I LV+ + IP N I G AF H +GIH +L Sbjct: 247 AIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLK 306 Query: 316 NPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDV 375 N YEI+ P G+ + +G A+K R+D++ ++ + + KL D Sbjct: 307 NRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADK 366 Query: 376 RSLNID 381 + D Sbjct: 367 KGQVFD 372 >gi|2984301 (AE000772) 2-isopropylmalate synthase [Aquifex aeolicus] Length = 524 Score = 139 bits (347), Expect = 3e-32 Identities = 105/378 (27%), Positives = 183/378 (47%), Gaps = 19/378 (5%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ TE+K+++A L VD IE AS + D EA+ ++ Sbjct: 11 IFDTTLRDGEQAPGFSMTTEEKLQMAHQLAKLNVDIIEAGFAAAS---KGDFEAVNRIAK 67 Query: 85 KAK---ILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKSAV 137 + K I + R D ++A + I TS +Y + + + Sbjct: 68 EVKGPVICSLARALESDIEIAAKALEPAERKRIHTFIATSPIHMEYKLRMTPDQVLERIK 127 Query: 138 EVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYEL 197 + + F ++ ++ FS ED+ RS+ L +T K G + I DTVG A P + +L Sbjct: 128 KAVSFARNFTDDVEFSCEDATRSEREFLYRAIETAIKHGATVINIPDTVGYAIPEEFGQL 187 Query: 198 IRTL-KSVVSCD---IECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGG 253 I + +V + D + H H+D G A AN+ TA++ GAR ++ ++ GIGER G L Sbjct: 188 IEDIMNNVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTINGIGERAGNAALEE 247 Query: 254 LMARMIVAAPDYVKSKYKLHKIRDI---ENLVADAVEVNIPFNNPITGFCAFTHKAGIHA 310 ++ + V D+ Y ++I L+ + N I G AF H++GIH Sbjct: 248 VVMALKVRK-DFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGDNAFAHESGIHQ 306 Query: 311 KAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIK 370 +L++ TYEI++P D G + +G +A+K R+++L T +++ + K K Sbjct: 307 HGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFKFTKEELDRIFEKFK 366 Query: 371 KLGD-VRSLNIDDVDSII 387 +L D + + +D++++I Sbjct: 367 ELADRKKEVYDEDLEALI 384 >gi|266631|sp|Q00853|NIVA_CLOPA HOMOCITRATE SYNTHASE, ALPHA SUBUNIT >gi|98609|pir||B39403 probable homocitrate synthase (EC 4.1.3.21) NifV omega chain - Clostridium pasteurianum >gi|144879 (M68878) nitrogen fixation protein [Clostridium pasteurianum] Length = 269 Score = 133 bits (331), Expect = 2e-30 Identities = 72/223 (32%), Positives = 113/223 (50%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 ++D+TLR+GEQ A + K+EIA+ + + GV IE P + I LGL Sbjct: 5 IVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGGDEKISVSKIAALGL 64 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 144 +KI R D ++E S + KD ++A++ + + Sbjct: 65 PSKIAAWNRMSTKDIDTSIECGVDIVHISSPVSDLQIKTKLEKDRKWVAENLKRTVIYAL 124 Query: 145 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 204 K E+ EDS R+DL L+ + + + +GV RV ADTVG P+++Y I+ ++ Sbjct: 125 EKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKELYSQIKKIRDK 184 Query: 205 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNG 247 V DIE H HND G AI+N++ A + GA+ D ++ G+GER G Sbjct: 185 VPIDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAG 227 >gi|2213884 (AF004166) 2-isopropylmalate synthase [Lycopersicon pennellii] Length = 612 Score = 131 bits (326), Expect = 9e-30 Identities = 110/413 (26%), Positives = 182/413 (43%), Gaps = 25/413 (6%) Query: 16 YLSNVNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKD 75 ++ + N ++ D+TLR+GEQ A T++K+++AR GVD IE P +SE + Sbjct: 64 HIPDPNYVRIFDTTLRDGEQSPGATMTTKEKLDVARQSAKLGVDIIEAGFPASSEADLEA 123 Query: 76 CEAICK---LGLKAK-----ILTHIRCHMDDAKVAVETXXXX----XXXXIGTSKFLRQY 123 + I K G+ + I RC+ D A E I TS+ Y Sbjct: 124 VKLIAKEVGNGVYEEEYVPVICGLARCNKKDIDKAWEAVKYAKKPRIHTFIATSEVHMNY 183 Query: 124 SHGKDMNYIAKSAVEVIEFVKSKGIE-IRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGI 182 + + + A ++ + +S G E + FS ED+ RSD L +I V K G + I Sbjct: 184 KLKMSRDQVVEKARSMVAYARSIGCEDVEFSPEDAGRSDPEFLYHILGEVIKAGATTLNI 243 Query: 183 ADTVGCANPRQVYELIRTLKS----VVSCDIECHFHNDTGCAIANAYTALEGGARLIDVS 238 DTVG P + +LI +K+ V I H ND G + AN GAR ++V+ Sbjct: 244 PDTVGYTVPEEFGQLIAKIKANTPGVEDVIISTHCQNDLGLSTANTLAGACAGARQLEVT 303 Query: 239 VLGIGERNGITPLGGLMARMIVAAPDYVKSKY---KLHKIRDIENLVADAVEVNIPFNNP 295 + GIGER G L ++ + + Y I +V +++ + Sbjct: 304 INGIGERAGNASLEEVVMALKCRGEQVLGGLYTGINTQHILMSSKMVEGISGLHVQPHKA 363 Query: 296 ITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFA---NRLTGWNAIKARVDQ 352 I G AF H++GIH +L + TYEI+ P D G+ R +L+G K ++ + Sbjct: 364 IVGANAFVHESGIHQDGMLKHKDTYEIISPEDIGLNRANESGIVFGKLSGVMLCKPKMLE 423 Query: 353 LNLNLTDDQIKEVTAKIKKLGDVRSLNIDDVDSIIKNFHAEVSTPQVLSAKKN 405 L + ++ ++ + K + + + D D ++ EV PQ + +N Sbjct: 424 LGYEIEGKELDDLFWRFKSVAEKKKKITD--DDLVALMSDEVFQPQFVWQLQN 474 >gi|78954|pir||S02508 homocitrate synthase (EC 4.1.3.21) - Klebsiella pneumoniae >gi|43832|emb|CAA31676| (X13303) nifV protein (AA 1-380) [Klebsiella pneumoniae] Length = 380 Score = 128 bits (319), Expect = 6e-29 Identities = 91/348 (26%), Positives = 159/348 (45%), Gaps = 3/348 (0%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ F T +K+ IA AL G+ +E+ +P ++ + + + A Sbjct: 8 DTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQLPDA 67 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 ++T R + + + + + I S LRQY + + + + I + Sbjct: 68 TLMTWCRMNALEIRQSADLGIDWVDISIPASDKLRQYKLREPLAVLLERLAMFIHLAHTL 127 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+++ ED+ R+ L I + + R+ ADTVG +P I L+ V S Sbjct: 128 GLKVCIGCEDASRASGQTLRAIAEVAQQCAAARLRYADTVGLLDPFTTAAQISALRDVWS 187 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYV 266 +IE H HND G A AN A+ GA ++ +VLG+GER G L + + V Sbjct: 188 GEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNAALETVALGLERCLG--V 245 Query: 267 KSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPH 326 ++ + VA+A + I P+ G FTH++G+H A+L + +Y+ + P Sbjct: 246 ETGVHFSALPASCQRVAEAAQRAIDPQQPLVGELVFTHESGVHVAALLRHSESYQSIAPS 305 Query: 327 DFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGD 374 G + Y + +G A+ DQ+ +L QI ++ I++ + Sbjct: 306 LMG-RSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQLLPAIRRFAE 352 >gi|2492791|sp|Q47884|NIFV_FRAAL HOMOCITRATE SYNTHASE >gi|1256029 (L41344) homocitrate synthase [Frankia alni] Length = 351 Score = 128 bits (319), Expect = 6e-29 Identities = 87/308 (28%), Positives = 136/308 (43%), Gaps = 6/308 (1%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ F +K+ IA ALD GV IE P R I A Sbjct: 27 DTTLRDGEQAPGVAFTAAEKLAIAAALDAIGVHQIEAGIPAMGVTERDVLREILATDPHA 86 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 I+ R D + A I S + G+D + + + + Sbjct: 87 DIVGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLGRDRAWARLRVRDCVADATDR 146 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+ + ED+ R+D + ++ + ++GV R+ ADTVG +P ++ + L V Sbjct: 147 GMRVSVGFEDASRADDAFVTDLAGELRELGVTRLRWADTVGLLDPVSAHDRLGRLVRAVP 206 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG--GLMARMIVAAPD 264 E H H+D G A AN A++ G + +VLG+GER G P+ + R ++ P Sbjct: 207 GPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEVAMALRHLLKLPV 266 Query: 265 YVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 324 + + R + LV+ A +P + G F H++GIH IL +P+TYE D Sbjct: 267 DLDTT----SFRSLARLVSRAARRPLPAGKAVVGESVFAHESGIHVHGILRHPATYEPFD 322 Query: 325 PHDFGMKR 332 P + G +R Sbjct: 323 PAEVGGRR 330 >gi|266629|sp|Q01181|NIFV_RHOSH HOMOCITRATE SYNTHASE >gi|282178|pir||D41880 isopropylmalate synthetase homolog NIfV - Rhodobacter sphaeroides >gi|151969 (M86823) nifV [Rhodobacter sphaeroides] Length = 391 Score = 127 bits (317), Expect = 1e-28 Identities = 92/312 (29%), Positives = 139/312 (44%), Gaps = 5/312 (1%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 L D+TLR+GEQ A F +K IA AL GV +E+ P E+ R D A+ + Sbjct: 21 LCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAVLK 80 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 144 A + R +D A T + S+ GKD ++ +++ Sbjct: 81 TAAPVVWCRLRAEDLAAAQRTGVVRLHIGVPVSERQISAKLGKDAAWVRDKVEKLVRAAS 140 Query: 145 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 204 G ++ +ED+ R+D L I + G R I+DT+G +P +EL+ + + Sbjct: 141 WAGHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGVLDPFAAHELVGRVVTR 200 Query: 205 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPD 264 +E H HND G A AN+ A GA + V+V G+GER G L + A + A Sbjct: 201 CPLPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNAALEEVAAALEAAGR- 259 Query: 265 YVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 324 + L ++ + LVA A + PI G FTH+ GIH ++ + +TYE D Sbjct: 260 --ATGVALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVDGLMKDRATYESAD 317 Query: 325 --PHDFGMKRYI 334 P FG I Sbjct: 318 LRPERFGRSHRI 329 >gi|128323|sp|P05345|NIFV_KLEPN HOMOCITRATE SYNTHASE >gi|479601|pir||S34848 nifV protein - Klebsiella pneumoniae >gi|43881|emb|CAA31119| (X12600) nifV gene product (AA 1 - 381) [Klebsiella pneumoniae] Length = 381 Score = 127 bits (316), Expect = 1e-28 Identities = 91/348 (26%), Positives = 158/348 (45%), Gaps = 2/348 (0%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ F T +K+ IA AL G+ +E+ +P ++ + + + A Sbjct: 8 DTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQLPDA 67 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 ++T R + + + + + I S LRQY + + + + I + Sbjct: 68 TLMTWCRMNALEIRQSADLGIDWVDISIPASDKLRQYKLREPLAVLLERLAMFIHLAHTL 127 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+++ ED+ R+ L I + R+ ADTVG +P I L+ V S Sbjct: 128 GLKVCIGCEDASRASGQTLRAIAEVAQNAPAARLRYADTVGLLDPFTTAAQISALRDVWS 187 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYV 266 +IE H HND G A AN A+ GA ++ +VLG+GER G A + V Sbjct: 188 GEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNAAAWKPSALGLERCLG-V 246 Query: 267 KSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPH 326 ++ + + VA+A + I P+ G FTH++G+H A+L + +Y+ + P Sbjct: 247 ETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFTHESGVHVAALLRDSESYQSIAPS 306 Query: 327 DFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGD 374 G + Y + +G A+ DQ+ +L QI ++ I++ + Sbjct: 307 LMG-RSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQLLPAIRRFAE 353 >gi|480804|pir||S37297 nifV protein - Klebsiella pneumoniae >gi|149345 (M17350) nifV-encoded protein [Klebsiella pneumoniae] Length = 381 Score = 124 bits (309), Expect = 9e-28 Identities = 90/348 (25%), Positives = 157/348 (44%), Gaps = 2/348 (0%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ F T +K+ IA AL G+ +E+ +P ++ + + + A Sbjct: 8 DTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQLPDA 67 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 ++T R + + + + + I S L QY + + + + I + Sbjct: 68 TLMTWCRMNALEIRQSADLGIDWVDISIPASDKLPQYKLREPLAVLLERLAMFIHLAHTL 127 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+++ ED+ R+ L I + R+ ADTVG +P I L+ V S Sbjct: 128 GLKVCIGCEDASRASGQTLRAIAEVAQNAPAARLRYADTVGLLDPFTTAAQISALRDVWS 187 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYV 266 +IE H HND G A AN A+ GA ++ +VLG+GER G A + V Sbjct: 188 GEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNAAAWKPSALGLERCLG-V 246 Query: 267 KSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPH 326 ++ + + VA+A + I P+ G FTH++G+H A+L + +Y+ + P Sbjct: 247 ETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFTHESGVHVAALLRDSESYQSIAPS 306 Query: 327 DFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGD 374 G + Y + +G A+ DQ+ +L QI ++ I++ + Sbjct: 307 LMG-RSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQLLPAIRRFAE 353 >gi|128321|sp|P23122|NIFV_AZOCH HOMOCITRATE SYNTHASE >gi|280010|pir||C43706 nifV protein - Azotobacter chroococcum >gi|142389 (M60090) homocitrate synthase [Azotobacter chroococcum] Length = 382 Score = 123 bits (307), Expect = 2e-27 Identities = 93/349 (26%), Positives = 159/349 (44%), Gaps = 15/349 (4%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ A F+ ++KI I RAL + GV +E+ P E+ R+ AI LGL + Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIRRALAELGVPELEIGIPSMGEEEREVMRAIAGLGLSS 67 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 ++L R D A T + S + ++ +D ++ ++ + Sbjct: 68 RLLAWCRLCDFDLSAARSTGVTMVDLSLPISDLMLRHKLNRDRDWALGEVARLVSEARMA 127 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+E+ ED+ R+D D + V + ADTVG P + + R L+ + Sbjct: 128 GLEVCLGCEDASRADQ-DFIVRVGAVAQAARPPPAFADTVGVMEPFGMLDRFRFLRQRLD 186 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYV 266 ++E H H+D G A AN A+ GGA I+ +V G+GER + ++A + Sbjct: 187 VELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAA----NAALEECVLA----L 238 Query: 267 KSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCA-----FTHKAGIHAKAILANPSTYE 321 K+ + + D + A + V G A FTH+AGIH +L + YE Sbjct: 239 KNLHGIDTGIDTRGIPAISALVERASGRQWPGRRAWLAPVFTHEAGIHVDGLLKHRRNYE 298 Query: 322 ILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIK 370 L+P + G + + +G + ++ +L + L D Q + + +I+ Sbjct: 299 GLNPDELGRSHSL-VLGKHSGAHMVRNSYRELGIELADWQSQALLGRIR 346 >gi|585559|sp|Q07179|NIFV_RHOCA HOMOCITRATE SYNTHASE >gi|486695|pir||S34817 nifV protein - Rhodobacter capsulatus >gi|297919|emb|CAA48488| (X68444) nifV [Rhodobacter capsulatus] Length = 382 Score = 123 bits (305), Expect = 3e-27 Identities = 95/313 (30%), Positives = 140/313 (44%), Gaps = 6/313 (1%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 L D+TLR+GEQ A F +K IARALD GV IE+ + A+ Sbjct: 9 LCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVVAEIA 68 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 144 A + R M D +A +T + TS + D ++I + ++ Sbjct: 69 HATPVVWCRLRMHDLDMAQKTGVKRVHFAVPTSTAQLEGKLRVDRDWILRETAALVFCAS 128 Query: 145 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 204 +G+++ +ED+ R+D L+ + + G R IADT+G +P + L+ L + Sbjct: 129 DRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDPLGAFRLVAELSAR 188 Query: 205 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPD 264 +S IE H HND G A AN A GA + V+V G+GER G + A + D Sbjct: 189 ISLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAACEEVGAALEAGGID 248 Query: 265 YVKSKYKLHKIRDIENLVADAVEVNIPFNNPITG-FCAFTHKAGIHAKAILANPSTYE-- 321 + L + ++ +VA A PITG F H++GIH AIL TYE Sbjct: 249 ---TGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLFAHESGIHVDAILKRADTYEDP 305 Query: 322 ILDPHDFGMKRYI 334 P FG +R I Sbjct: 306 RCAPARFGRERQI 318 >gi|2492789|sp|Q44290|NIFV_ANASP HOMOCITRATE SYNTHASE >gi|1487879|emb|CAA68174| (X99902) homocitrate synthase [Anabaena sp.] Length = 379 Score = 120 bits (299), Expect = 1e-26 Identities = 74/228 (32%), Positives = 115/228 (49%), Gaps = 2/228 (0%) Query: 20 VNNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAI 79 +N + D+TLR+GEQ A F E+K+ IA+ LD GV +E+ P E+ + AI Sbjct: 1 MNKVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAI 60 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEV 139 LGLKA +L R + D K +V I S ++ HG+ + K+ + Sbjct: 61 SNLGLKANLLAWNRAVISDIKASVACGMERVHIAIPVSDVKAKF-HGQWRVSLPKTQ-RL 118 Query: 140 IEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIR 199 F +G+ + EDS R+D LL++ + G +R DTVG +P Y ++ Sbjct: 119 YHFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYGKVK 178 Query: 200 TLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNG 247 L S ++ +E H HND G A NA ++ GA ++ +V+G+GER G Sbjct: 179 LLVSALTIPVEVHTHNDFGMATLNALAGIKAGASSVNTTVIGLGERAG 226 >gi|1709287|sp|P54610|NIFV_FRASP HOMOCITRATE SYNTHASE >gi|1280032 (U53363) homocitrate synthase [Frankia sp.] Length = 401 Score = 120 bits (297), Expect = 2e-26 Identities = 92/363 (25%), Positives = 155/363 (42%), Gaps = 16/363 (4%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+TLR+GEQ F +K+ IA ALD GV IE P R I KA Sbjct: 26 DTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILATDPKA 85 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 +I+ R D + A I S + +D + + + + + Sbjct: 86 EIVGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLERDRAWARRRVRDCVVDGTDR 145 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+ + ED+ R+D + ++ + +GV R+ ADTVG +P Y+ + L V Sbjct: 146 GMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLDPVSAYDRLGRLVRAVP 205 Query: 207 CDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG--GLMARMIVAAPD 264 E H H+D G A AN A++ G + +VLG+GER G P+ + R ++ P Sbjct: 206 GPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEVAMALRHLLKLPI 265 Query: 265 YVKSKYKLHKIRDIENLVADAVEVNIPF---NNPITGFCAFTHKAGIHAKAILANPSTYE 321 + + R + LV V P + G F H++GIH IL +P+TYE Sbjct: 266 DLDTT----SFRTLAQLV-----VGWPLPAGKKAVVGESVFAHESGIHVHGILRHPATYE 316 Query: 322 ILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNID 381 DP G +R + +G +++ ++Q + + +++ + +++ +D Sbjct: 317 PFDPEVGGRRRLT--VGKHSGRASLRHALEQCGITAEESELEPLVEQVRLAATRHKRGLD 374 Query: 382 DVD 384 D Sbjct: 375 SRD 377 >gi|2492790|sp|Q52070|NIFV_ENTAG HOMOCITRATE SYNTHASE >gi|1480128|emb|CAA68021| (X99694) nifV [Enterobacter agglomerans] Length = 400 Score = 119 bits (296), Expect = 3e-26 Identities = 90/352 (25%), Positives = 162/352 (45%), Gaps = 11/352 (3%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCE--AICKLGL 84 D+TLR+GEQ F +K+EIA+AL + GV +E +P E+ +C AI + L Sbjct: 22 DTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEE---ECVRLAILRRQL 78 Query: 85 KAKILTHIRCHMDDAKV--AVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEF 142 ++ C M+ A++ + + S LR+ + + S +++ Sbjct: 79 PDTVMMSW-CRMNSAEIHDSARVGMDWVDISVPASDLLREQKLHRPWPAVIASLKPLVQL 137 Query: 143 VKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLK 202 G+ + ED+ RS L + + +G+ R+ ADT+G +P + I L+ Sbjct: 138 AHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGILDPFSTFTRISALR 197 Query: 203 SVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAA 262 +E H HND G A AN A+ GA ++ +VLG+GER G L + + Sbjct: 198 QHWHGGLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAALESVTLSLDRCL 257 Query: 263 PDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEI 322 ++ ++ + LVA A I +P+ G FTH++G+H A+L +P +Y+ Sbjct: 258 --HLDCGIDFTELPALCRLVAAAAGRTIDVQHPLVGGQVFTHESGLHVAALLRDPRSYQG 315 Query: 323 LDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGD 374 +DP G + + + +G A+ +L L++ Q + ++K+ + Sbjct: 316 IDPSLVG-REFNLVLGKHSGRQAVSGICARLGYILSETQTLLMLQEVKRFAE 366 >gi|3355677|emb|CAA19977| (AL031124) putative lyase [Streptomyces coelicolor] Length = 534 Score = 116 bits (288), Expect = 3e-25 Identities = 91/366 (24%), Positives = 166/366 (44%), Gaps = 16/366 (4%) Query: 21 NNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKD-CEAI 79 ++F + D+TLR+G Q K+ IAR LDDFGV +IE P A+ + + A Sbjct: 9 DSFHVFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARAR 68 Query: 80 CKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKF-LRQYSHGKDMNYIAKSAVE 138 ++ K L A E G L SH + + ++ ++ Sbjct: 69 QEIDFKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTTLD 128 Query: 139 --------VIEFVKSKGIEIRFSSE---DSFRSDLVDLLNIYKTVDKIGVNRVGIADTVG 187 + +K++G + E D +R++ ++ +T + G + V + DT G Sbjct: 129 ENLAMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDTNG 188 Query: 188 CANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNG 247 P Q+ ++ T+ + + H +DTGCA+AN A++ GA + + G GER G Sbjct: 189 GMLPAQIQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVG 248 Query: 248 ITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAG 307 L ++A + + V + +L ++ I + +A+ V + + P G AF HKAG Sbjct: 249 NANLFPVVAALELKYGKQVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAG 308 Query: 308 IHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQ--IKEV 365 +HA AI +P Y+ +DP G + + + G +I+ + +L ++L D+ + V Sbjct: 309 LHASAIKVDPDLYQHIDPELVGNTMRM-LVSDMAGRASIELKGKELGIDLGGDRELVGRV 367 Query: 366 TAKIKK 371 ++K+ Sbjct: 368 VERVKE 373 >gi|126191|sp|P15875|LEU1_SALTY 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|79038|pir||S08431 2-isopropylmalate synthase (EC 4.1.3.12) - Salmonella typhimurium >gi|47968|emb|CAA35931| (X51583) isopropylmalate synthase (AA 1-522) [Salmonella typhimurium] Length = 522 Score = 111 bits (276), Expect = 7e-24 Identities = 82/314 (26%), Positives = 138/314 (43%), Gaps = 9/314 (2%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 + D+TLR+GEQ A ++K++IA AL+ GVD +E+ PV+S + + I + Sbjct: 7 IFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIK 66 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXX----XXIGTSKFLRQYSHGKDMNYIAKSAVEVI 140 +++ RC D VA + I TS + ++ + + AV ++ Sbjct: 67 NSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRRTLDEVIERAVYMV 126 Query: 141 EFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRT 200 + ++ ++ FS ED+ R+ + DL + + G + I DTVG P + +I Sbjct: 127 KRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISG 186 Query: 201 L----KSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGG-LM 255 L ++ I H H+D G A+ N+ A+ GAR ++ ++ GIGER G L +M Sbjct: 187 LYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIM 246 Query: 256 ARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILA 315 A + V + H+ + P F H +GIH +L Sbjct: 247 AIKVRKDIMNVHTNINHHETGAPARPSVQICNIADPSQQSDCRQRRFRHSSGIHQDGVLK 306 Query: 316 NPSTYEILDPHDFG 329 N YEI+ P G Sbjct: 307 NRENYEIMTPESIG 320 >gi|1653449|gnl|PID|d1019096 (D90913) alpha-isopropylmalate synthase [Synechocystis sp.] Length = 547 Score = 104 bits (258), Expect = 9e-22 Identities = 94/374 (25%), Positives = 164/374 (43%), Gaps = 31/374 (8%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84 L D+TLR+G Q K+ IAR LD G+ +IE P A+ KD + +L Sbjct: 10 LYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANP---KDVQFFWQLQE 66 Query: 85 K----AKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVI 140 + A+I+ C AVET ++++ + D++ + + Sbjct: 67 EPLEQAEIVAF--CSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLA 124 Query: 141 E----------FVKSKGIEIRFSSE---DSFRSDLVDLLNIYKTVDKIGVNRVGIADTVG 187 E +++S+G + + +E D +R++ L T + G + + DT G Sbjct: 125 ENLAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMCDTNG 184 Query: 188 CANPRQVYELIRTLKSVVSCD--------IECHFHNDTGCAIANAYTALEGGARLIDVSV 239 P Q+ E+ ++ + D + H HND+G A+AN+ A+E GA ++ ++ Sbjct: 185 GTLPGQISEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMVQGTI 244 Query: 240 LGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGF 299 G GER G L L+ + + KL + L+++ V + + P G Sbjct: 245 NGYGERCGNANLCTLIPNLQLKLDYDCIEPEKLAHLTSTSRLISEIVNLAPDDHAPFVGR 304 Query: 300 CAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAI-KARVDQLNLNLT 358 AF HK GIH A+ NP TYE + P+ G +R I + + N + KA + + L+ Sbjct: 305 SAFAHKGGIHVSAVQRNPFTYEHIAPNLVGNERRIVVSEQAGLSNVLSKAELFGIALDRQ 364 Query: 359 DDQIKEVTAKIKKL 372 + + + A +K L Sbjct: 365 NPACRTILATLKDL 378 >gi|1597740 (U26427) nifV [Azospirillum brasilense] Length = 376 Score = 104 bits (257), Expect = 1e-21 Identities = 91/329 (27%), Positives = 147/329 (44%), Gaps = 25/329 (7%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D+ R+GEQ A F ++KI IA+ALD+ GV +E+ P + R+ A+ LGLKA Sbjct: 9 DTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRAVASLGLKA 68 Query: 87 KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 +++ R H D K + ++ + + + + ++ + Sbjct: 69 RLMVWCRMHDTDLKARSTAVAPSLSVPVSDIHITKKLNGSR--AWALREIERKVKTARDH 126 Query: 147 GIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS 206 G+E+ EDS R+D+ D L TV + R ADT+G +P ++ R + + Sbjct: 127 GLEVSLGGEDSSRADM-DFLIAAATVAQ--RPRFRFADTLGVLDP---FQHARLHLTAAA 180 Query: 207 CDIECHFHNDTGCAIANA-----YTALEGGARLIDVSVLGIGERNGITPLGGLMARM-IV 260 D E +H T +ANA A+ GGA ++ +V G+GER G PL ++ + ++ Sbjct: 181 TDPEIGYHAHTP-RLANATAWVTLAAVLGGATHVNTTVNGLGERAGNAPLEEVVVSLKVL 239 Query: 261 AAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTY 320 D L I D LV A + N I FTH+AGIH +L + + Sbjct: 240 YGQDCGVDTRALGAISD---LVERASNRPVAVNKSIVRDAVFTHEAGIHVDGLLTDRAPT 296 Query: 321 EILDPHDFGMKRYIHFANRLTGWNAIKAR 349 I P +G A+ + W +I AR Sbjct: 297 RISTPPRWG-------ASTASCWASIPAR 318 >gi|2239049|emb|CAA72697| (Y11966) 2-isopropylmalate synthase [Buchnera aphidicola] Length = 375 Score = 101 bits (248), Expect = 1e-20 Identities = 67/228 (29%), Positives = 107/228 (46%), Gaps = 5/228 (2%) Query: 159 RSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVV----SCDIECHFH 214 R+ + +L I ++ K G + I DTVG P Q +I+ L + V + I H H Sbjct: 2 RTSIDNLCRIVESAIKAGATTINIPDTVGYTIPSQFKTIIKNLFNKVPNINNAIISAHCH 61 Query: 215 NDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDY-VKSKYKLH 273 +D G A+ NA ++E G R I+ ++ GIGER G T L ++ + + V + K + Sbjct: 62 DDLGLAVGNAIASIEAGVRQIEGTISGIGERAGNTALEEVILTIKLKEELLNVFTNIKHN 121 Query: 274 KIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRY 333 ++ L++ IP N I G AF H +GIH IL N + YEI+DP G+K Sbjct: 122 ELYRTSQLISQLCNTPIPANKSIIGSNAFAHSSGIHQDGILKNRANYEIIDPKTIGVKAV 181 Query: 334 IHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKKLGDVRSLNID 381 +G A+K + ++ D + ++ KL D + D Sbjct: 182 QLNLTSRSGRAAVKHHMHEMGYQDDDYDLNQLYVNFLKLADKKGQVFD 229 >gi|2492786|sp|Q56216|LEU1_THETH 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) >gi|1293674 (U52907) isopropylmalate synthase [Thermus aquaticus thermophilus] Length = 331 Score = 84.7 bits (206), Expect = 1e-15 Identities = 50/184 (27%), Positives = 99/184 (53%), Gaps = 3/184 (1%) Query: 209 IECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDY-VK 267 I H H+D G A ANA +E GA I+ ++ GIGER G L ++ + V Y Sbjct: 12 ISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWYKAY 71 Query: 268 SKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHD 327 ++ +I + LV + +P N I G AF H++GIH ++ + +TYEI+D Sbjct: 72 TRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMDAEL 131 Query: 328 FGMKRYIHFANRLTGWNAIKARVDQLNL-NLTDDQIKEVTAKIKKLGDVRS-LNIDDVDS 385 G + + + +G A K ++ L +L+++++K++ A+ K++ + + L+ +++ + Sbjct: 132 IGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEKKGPLSAEELQA 191 Query: 386 IIKN 389 ++++ Sbjct: 192 LVES 195 >gi|1709223|sp|P51017|NAHM_PSEPU 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|595673 (U13232) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas putida] Length = 346 Score = 57.0 bits (135), Expect = 2e-07 Identities = 49/161 (30%), Positives = 78/161 (48%), Gaps = 19/161 (11%) Query: 170 KTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVS--CDIECHFHNDTGCAIANAYTA 227 K ++ G N + D+ G P +V E I L++ ++ ++ H H++ G AIAN+ A Sbjct: 155 KLMESYGANCIYCTDSAGYMLPDEVSEKIGLLRAELNPATEVGFHGHHNMGMAIANSLAA 214 Query: 228 LEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDI-ENLV---- 282 +E GA ID SV G+G G TPL +A V V++ L+KI D+ E+LV Sbjct: 215 IEAGAARIDGSVAGLGAGAGNTPLEVFVA---VCKRMGVETGIDLYKIMDVAEDLVVPMM 271 Query: 283 -----ADAVEVNIPFNNPITGFCAFTHKA----GIHAKAIL 314 D + + + + F F +A G+ A+ IL Sbjct: 272 DQPIRVDRDALTLGYAGVYSSFLLFAQRAEKKYGVSARDIL 312 >gi|4104771 (AF039534) 2-oxo-4-hydroxypentanoate aldolase [Pseudomonas stutzeri] Length = 346 Score = 55.4 bits (131), Expect = 7e-07 Identities = 73/295 (24%), Positives = 117/295 (38%), Gaps = 58/295 (19%) Query: 22 NFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTS-------------PVA 68 N L D +LR+G E+ I +A LD G+ IE+T P Sbjct: 7 NVTLHDMSLRDGMHAKRHQISLEQMIAVATGLDAAGMPLIEITHGDGLGGRSINYGFPAH 66 Query: 69 SE------------QSRKDCEAICKLGLKAKILTHIRCHMDDAKVAVE-TXXXXXXXXIG 115 S+ Q++ + +G + + C + +VA T IG Sbjct: 67 SDEEYLRAVIPRLKQAKVSALLLPGIGTVDHLKMALDCGVSTIRVATHCTEADVSEQHIG 126 Query: 116 TSKFLRQYSHGKDMNYIAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKI 175 S+ L + G M SA +V+E + ++ Sbjct: 127 MSRKLGADTVGFLMMAHMISAEKVLEQAR--------------------------LMESY 160 Query: 176 GVNRVGIADTVGCANPRQVYELIRTLKSVVS--CDIECHFHNDTGCAIANAYTALEGGAR 233 G N + D+ G P +V E I L++ ++ +I H H++ G AIAN+ A+E GA Sbjct: 161 GANCIYCTDSAGYMLPDEVSEKIGLLRAELNPATEIGFHGHHNMGMAIANSLAAIEAGAS 220 Query: 234 LIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDI-ENLVADAVE 287 ID SV G+G G TPL +A V V++ L+KI D+ E++V ++ Sbjct: 221 RIDGSVAGLGAGAGNTPLEVFVA---VCKRMGVETGIDLYKIMDVAEDIVVPMMD 272 >gi|2266426|emb|CAA74217| (Y13917) yngG [Bacillus subtilis] >gi|2634206|emb|CAB13706| (Z99113) similar to hydroxymethylglutaryl-CoA lyase [Bacillus subtilis] Length = 299 Score = 54.3 bits (128), Expect = 2e-06 Identities = 51/228 (22%), Positives = 101/228 (43%), Gaps = 19/228 (8%) Query: 31 REGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASE--QSRKDCEAICKLGLKAKI 88 R+G Q + TE KI L G+ YIE+TS V + + +D + K + K Sbjct: 15 RDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAIDVAKGIDREKG 74 Query: 89 LTHIRC--HMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVKSK 146 +T+ + + A+E + S + + K++N ++ +++ V + Sbjct: 75 VTYAALVPNQRGLENALEGGINEACVFMSAS----ETHNRKNINKSTSESLHILKQVNND 130 Query: 147 GIEIRFSSEDSFRS----------DLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYE 196 + ++ + + ++ + + + + G++ + + DT+G ANP QV Sbjct: 131 AQKANLTTRAYLSTVFGCPYEKDVPIEQVIRLSEALFEFGISELSLGDTIGAANPAQVET 190 Query: 197 LIRTLKSVVSCD-IECHFHNDTGCAIANAYTALEGGARLIDVSVLGIG 243 ++ L + + I HFH+ G A+AN TAL+ G + D S G+G Sbjct: 191 VLEALLARFPANQIALHFHDTRGTALANMVTALQMGITVFDGSAGGLG 238 >gi|2822273 (AF006691) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas putida] Length = 344 Score = 53.1 bits (125), Expect = 3e-06 Identities = 65/281 (23%), Positives = 112/281 (39%), Gaps = 34/281 (12%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSP-----------VASEQSRKD 75 D TLR+G E+ IA+ LD GV IE+T + + Sbjct: 12 DMTLRDGMHPKRHQMTLEQMTSIAQGLDAAGVPLIEVTHGDGLGGSSINYGFPAHTDEEY 71 Query: 76 CEAICKLGLKAKILTHIRCHM---DDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYI 132 ++ L KAK+ + + DD K+A E S+ H + Y Sbjct: 72 LSSVIPLMKKAKVSALLLPGIGTVDDLKMAHELGVSTIRVATHCSEADVSQQH---IQYA 128 Query: 133 AKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPR 192 K ++ + F+ + + LL + ++ G N + D+ G P Sbjct: 129 RKIEMDTVGFLMM-----------AHMASPEQLLEQARRMESYGANCIYCTDSAGYMLPE 177 Query: 193 QVYELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITP 250 V I L+ ++ + E H H++ +AN+ A+E GA ID + G+G G TP Sbjct: 178 DVKARIGLLREKLNPETELGFHGHHNLAMGVANSLVAVEYGANRIDAAAAGLGAGAGNTP 237 Query: 251 LGGLMARMIVAAPDYVKSKYKLHKIRDI-ENLVADAVEVNI 290 + +A V A +++ + KI+D+ E+LV ++ I Sbjct: 238 MEVFIA---VCARSGIETGVDVFKIQDVAEDLVVPMMDFPI 275 >gi|2104392|emb|CAB08693| (Z95390) mhpE [Mycobacterium tuberculosis] Length = 336 Score = 53.1 bits (125), Expect = 3e-06 Identities = 49/247 (19%), Positives = 90/247 (35%), Gaps = 28/247 (11%) Query: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVA-------------SEQ 71 ++D+T+R+G N + + I LD G+ YIE+ V E+ Sbjct: 12 VLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDEE 71 Query: 72 SRKDCEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNY 131 + ++ + ++ ++ +A + I T L Sbjct: 72 YFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFEL----------- 120 Query: 132 IAKSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANP 191 + +E +SKG+E+ S + L K +GV V + DT G P Sbjct: 121 ----VMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLP 176 Query: 192 RQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPL 251 + L+ + H HN+ A+AN A + GA +D +++G G G + Sbjct: 177 EDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQI 236 Query: 252 GGLMARM 258 L+A + Sbjct: 237 ECLVAAL 243 >gi|2498245|sp|Q51983|CMTG_PSEPU 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|1263190 (U24215) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas putida] >gi|1588772|prf||2209341M 4-hydroxy-2-oxovalerate aldolase [Pseudomonas putida] Length = 350 Score = 53.1 bits (125), Expect = 3e-06 Identities = 67/278 (24%), Positives = 110/278 (39%), Gaps = 33/278 (11%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQS--------RKDCEA 78 D TLR+G + IARALD+ GVD IE+ + S D E Sbjct: 12 DVTLRDGMHAVRHQYSLADAERIARALDEAGVDSIEVAHGDGLQGSSFNYGFGAHTDLEW 71 Query: 79 ICKLGL---KAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKS 135 I ++ +AKI T + + T + +R +H + A Sbjct: 72 IERVAATVRRAKIATLLL-------PGIGTVHDLKNANAAGASVVRVATHCTE----ADI 120 Query: 136 AVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVY 195 + + IE+ + G++ S + L K ++ G + + D+ G N + Sbjct: 121 SQQHIEYARKLGMDTVGFLMMSHMTTPTALAVEAKKMESYGAQCIYVVDSGGAMNMYDIA 180 Query: 196 ELIRTLKSVV--SCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGG 253 + + LK V+ S H H++ +AN+ ALE G ID S+ G+G G PL Sbjct: 181 DRFKALKDVLDPSTQTGMHAHHNLSLGVANSIVALEYGCDRIDASLTGMGAGAGNAPL-- 238 Query: 254 LMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIP 291 + +AA D + K+ D+ L+ A E+ P Sbjct: 239 ---EVFIAAVDRMGLKHGC----DVRKLIDAAEEIVRP 269 >gi|2339989|emb|CAB11339| (Z98682) putative pyruvate carboxylase [Bacillus subtilis] Length = 920 Score = 50.4 bits (118), Expect = 2e-05 Identities = 25/79 (31%), Positives = 40/79 (49%) Query: 161 DLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCA 220 DL ++ K ++ G + +GI D G P+ YEL+ LK + + H H+ +G Sbjct: 462 DLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHLHTHDTSGNG 521 Query: 221 IANAYTALEGGARLIDVSV 239 I A+E G +IDV+V Sbjct: 522 IYMYAKAVEAGVDIIDVAV 540 >gi|2633857|emb|CAB13359| (Z99111) pyruvate carboxylase [Bacillus subtilis] Length = 1148 Score = 50.4 bits (118), Expect = 2e-05 Identities = 25/79 (31%), Positives = 40/79 (49%) Query: 161 DLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCA 220 DL ++ K ++ G + +GI D G P+ YEL+ LK + + H H+ +G Sbjct: 690 DLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHLHTHDTSGNG 749 Query: 221 IANAYTALEGGARLIDVSV 239 I A+E G +IDV+V Sbjct: 750 IYMYAKAVEAGVDIIDVAV 768 >gi|3426048 (AC005168) putative hydroxymethylglutaryl-CoA lyase precursor [Arabidopsis thaliana] Length = 433 Score = 50.4 bits (118), Expect = 2e-05 Identities = 30/117 (25%), Positives = 55/117 (46%), Gaps = 4/117 (3%) Query: 168 IYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCD-IECHFHNDTGCAIANAYT 226 + K + +G + + DT+G P V ++ + +VV D + HFH+ G A+AN Sbjct: 288 VVKELYDMGCFEISLGDTIGIGTPGSVVPMLEAVMAVVPADKLAVHFHDTYGQALANILV 347 Query: 227 ALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVA 283 +L+ G ++D S+ G+G G G + Y+ + +H D+ L+A Sbjct: 348 SLQMGISIVDSSIAGLG---GCPYAKGASGNVATEDVVYMLNGLGVHTNVDLGKLIA 401 >gi|99030|pir||S20683 phosphinomethylmalic acid synthase - Streptomyces viridochromogenes >gi|47998|emb|CAA46312| (X65195) phosphinomethylmalic-acid-synthase [Streptomyces viridochromogenes] Length = 207 Score = 49.6 bits (116), Expect = 4e-05 Identities = 32/105 (30%), Positives = 48/105 (45%), Gaps = 2/105 (1%) Query: 209 IECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKS 268 IE H HNDT +AN A+ G +I + LG GER G PL +M ++ + + Sbjct: 14 IELHPHNDTWLTVANCLAAIREGCGVISGTTLGTGERTGNAPLEAVMVHLL-GMGYWPEG 72 Query: 269 KYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAI 313 L + + L D + P+ G A+ +AGIHA + Sbjct: 73 GVDLTAVNKLVELY-DGIGAGPSQKYPLFGRDAYVTRAGIHADGL 116 >gi|1762117 (U41280) 3-hydroxy-3-methylglutaryl-CoA lyase [Rhodospirillum rubrum] Length = 303 Score = 49.6 bits (116), Expect = 4e-05 Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 1/70 (1%) Query: 175 IGVNRVGIADTVGCANPRQVYELIRTLKSVVSCD-IECHFHNDTGCAIANAYTALEGGAR 233 +G + + + DT+G PR+ E+++ + V + HFH+ G A+AN LE G Sbjct: 168 MGCHEISLGDTIGVGTPRRAREMVQAVAGAVPVQRLAAHFHDTYGQALANILAVLEIGVT 227 Query: 234 LIDVSVLGIG 243 D SV G+G Sbjct: 228 TFDCSVAGLG 237 >gi|3257245|gnl|PID|d1030871 (AP000003) 571aa long hypothetical oxaloacetate decarboxylase alpha chain [Pyrococcus horikoshii] Length = 571 Score = 48.8 bits (114), Expect = 7e-05 Identities = 33/119 (27%), Positives = 53/119 (43%), Gaps = 14/119 (11%) Query: 174 KIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGAR 233 ++ V+ + I D G A+P+ YEL++ +K + H H +G A+A A+E G Sbjct: 163 ELDVDYITIKDMAGLADPQTAYELVKEIKERYGIKVNFHTHATSGLAVATYLKAVEAGVD 222 Query: 234 LIDVSVLGIGERNGITPLGGLMAR-----MIVAAPDYVKSKYKLHKIRDIENLVADAVE 287 ID S I PL G A+ M A P + K + I +I + + +E Sbjct: 223 YIDTS---------IYPLAGGTAQPAVQTMYYALPKGKRPKLNIKLIHEISKYLTNLLE 272 >gi|2627157|gnl|PID|d1024439 (AB008831) 4-hydroxy-2-oxovalerate aldolase [Acinetobacter sp.] Length = 340 Score = 48.4 bits (113), Expect = 9e-05 Identities = 50/155 (32%), Positives = 72/155 (46%), Gaps = 20/155 (12%) Query: 176 GVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGAR 233 G N + D+ G P +V I L+S + +IE H H++ G AIAN+ A G +R Sbjct: 160 GANCIYATDSAGYMLPDEVTAKIGLLRSELPSNIEVGFHGHHNMGMAIANSLAARSGASR 219 Query: 234 LIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDI-ENLV---------A 283 ID SV G+G G TPL A V V++ L+KI D+ E+LV Sbjct: 220 -IDGSVAGLGAGAGNTPLEVFCA---VLDRMGVETGVDLYKIMDVAEDLVVPIMDQPIRV 275 Query: 284 DAVEVNIPFNNPITGFCAFTHKA----GIHAKAIL 314 D + + + + F F +A GI A+ IL Sbjct: 276 DRNALTLGYAGVYSSFLLFAERAEKKYGISARDIL 310 >gi|1732457|gnl|PID|d1010339 (D63377) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas fluorescens] Length = 344 Score = 48.0 bits (112), Expect = 1e-04 Identities = 68/279 (24%), Positives = 116/279 (41%), Gaps = 30/279 (10%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGLKA 86 D TLR+G E+ IAR LD GV IE+T S G A Sbjct: 12 DMTLRDGMHPKQHQMTLEQMTSIARGLDAAGVPLIEVTHGDGLGGSS------INYGFPA 65 Query: 87 ----KILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYI--------AK 134 + L+ + M AKV+ IGT L+ +H ++ I A Sbjct: 66 HTDEEYLSSVIPLMKQAKVSA-----LLLPGIGTVDNLKM-AHELGVHTIRVATHCSEAD 119 Query: 135 SAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQV 194 + + I++ ++ G++ + + LL ++ G N + D+ G P V Sbjct: 120 VSQQHIQYARNIGMDTVGFLMMAHMASPEQLLEQALLMESYGANCIYCTDSAGYMLPEDV 179 Query: 195 YELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLG 252 I L+ ++ + E H H++ +AN+ A+E GA ID + G+G G TP+ Sbjct: 180 KARIGLLREKLNPETELGFHGHHNLAMGVANSLMAVEYGANRIDAAAAGLGAGAGNTPME 239 Query: 253 GLMARMIVAAPDYVKSKYKLHKIRDI-ENLVADAVEVNI 290 +A V + +++ + KI+D+ E+LV ++ I Sbjct: 240 VFIA---VCSRSGIETGVDVFKIQDVAEDLVVPMMDFPI 275 >gi|1705497|sp|P51014|BPHF_PSES1 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|1073055|pir||C55511 4-hydroxy-2-oxovalerate aldolase - Pseudomonas sp. (strain KKS102) >gi|425214|gnl|PID|d1004409 (D16407) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas sp.] Length = 352 Score = 48.0 bits (112), Expect = 1e-04 Identities = 55/238 (23%), Positives = 92/238 (38%), Gaps = 24/238 (10%) Query: 27 DSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKD----------- 75 D TLR+G + E+ IA+ LD+ VD IE+ + S + Sbjct: 10 DVTLRDGSHAIRHQYSVEQVRTIAKELDEAKVDSIEVAHGSGLQGSSFNYGFGAHTDLEW 69 Query: 76 CEAICKLGLKAKILTHIRCHMDDAKVAVETXXXXXXXXIGTSKFLRQYSHGKDMNYIAKS 135 EA+ + AKI T + + T ++ +R +H + A Sbjct: 70 IEAVASVVKHAKIATLLL-------PGIGTIHDLKAAYDAGARIVRVATHCTE----ADI 118 Query: 136 AVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVY 195 + + IE+ + G+E S S L K ++ G + D+ G + V Sbjct: 119 SKQHIEYARHLGMEAVGFLMMSHMSTPQGLAQQAKLMESYGATCCYVVDSGGALSMDDVR 178 Query: 196 ELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPL 251 R K V+ + E H H++ +AN+ A+E G +D S+ G+G G PL Sbjct: 179 MRFRAFKDVLKPETETGIHAHHNLSLGVANSIVAIEEGCDRVDASLAGMGAGAGNAPL 236 >gi|3130042|emb|CAA19019| (AL023534) 2-isopropylmalate synthase [Schizosaccharomyces pombe] Length = 460 Score = 47.3 bits (110), Expect = 2e-04 Identities = 43/162 (26%), Positives = 61/162 (37%), Gaps = 23/162 (14%) Query: 185 TVGCANPRQVYELIRTLKSVVS-----CDIECHFHNDTGCAIANAYTALEGGARLIDVSV 239 TV + P +LI + +S C + H HND G A+A A G I+ + Sbjct: 107 TVEMSTPNTYADLIEYFSTNISEREKVC-VSLHPHNDRGTAVAAAELGQLAGGDRIEGCL 165 Query: 240 LGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGF 299 G GER G L L + V K+ +I + D ++N+ +P G Sbjct: 166 FGNGERTGNVDLVTLAFNLYTQG---VSPNLDFSKLDEIIRITEDCNKINVHPRHPYAGN 222 Query: 300 CAFTHKAGIHAKAILANPSTYE--------------ILDPHD 327 FT +G H AI Y+ LDPHD Sbjct: 223 LVFTAFSGSHQDAISKGLKAYDERKAVDPVWKVPYLPLDPHD 264 >gi|3560136|emb|CAA20723| (AL031534) 2-isopropylmalate synthase. [Schizosaccharomyces pombe] Length = 584 Score = 47.3 bits (110), Expect = 2e-04 Identities = 43/162 (26%), Positives = 61/162 (37%), Gaps = 23/162 (14%) Query: 185 TVGCANPRQVYELIRTLKSVVS-----CDIECHFHNDTGCAIANAYTALEGGARLIDVSV 239 TV + P +LI + +S C + H HND G A+A A G I+ + Sbjct: 231 TVEMSTPNTYADLIEYFSTNISEREKVC-VSLHPHNDRGTAVAAAELGQLAGGDRIEGCL 289 Query: 240 LGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGF 299 G GER G L L + V K+ +I + D ++N+ +P G Sbjct: 290 FGNGERTGNVDLVTLAFNLYTQG---VSPNLDFSKLDEIIRITEDCNKINVHPRHPYAGN 346 Query: 300 CAFTHKAGIHAKAILANPSTYE--------------ILDPHD 327 FT +G H AI Y+ LDPHD Sbjct: 347 LVFTAFSGSHQDAISKGLKAYDERKAVDPVWKVPYLPLDPHD 388 >gi|2129173|pir||F64453 oxaloacetate decarboxylase (EC 4.1.1.3) alpha subunit - Methanococcus jannaschii >gi|1591862 (U67563) oxaloacetate decarboxylase alpha chain (oadA) [Methanococcus jannaschii] Length = 567 Score = 46.9 bits (109), Expect = 3e-04 Identities = 21/74 (28%), Positives = 40/74 (53%) Query: 166 LNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAY 225 + + K ++++G + + I D G P + YEL++ LK +S I+ H H +G A Sbjct: 155 VELAKKLEEMGCDSICIKDMAGLLTPYEGYELVKRLKEEISLPIDVHSHCTSGLAPMTYL 214 Query: 226 TALEGGARLIDVSV 239 +E GA ++D ++ Sbjct: 215 KVIEAGADMVDCAI 228 >gi|127562|sp|P13703|HMGL_PSEMV HYDROXYMETHYLGLUTARYL-COA LYASE (HMG-COA LYASE) (HL) (3-HYDROXY-3-METHYLGLUTARATE-COA LYASE) >gi|94971|pir||A30578 hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) - Pseudomonas sp >gi|151372 (M31807) HMG-CoA-lyase (mvaB) [Pseudomonas mevalonii] >gi|151374 (M24016) HMG-CoA lysase (EC 4.1.3.4) [Pseudomonas mevalonii] Length = 301 Score = 46.5 bits (108), Expect = 3e-04 Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 1/71 (1%) Query: 174 KIGVNRVGIADTVGCANPRQVYELIRTL-KSVVSCDIECHFHNDTGCAIANAYTALEGGA 232 ++G + + DT+G P + +L + + + HFH+ G AIAN + AL G Sbjct: 165 ELGCYEISLGDTIGAGRPDETAQLFELCARQLPVAALAGHFHDTWGMAIANVHAALAQGV 224 Query: 233 RLIDVSVLGIG 243 R D SV G+G Sbjct: 225 RTFDSSVAGLG 235 >gi|1705498|sp|P51015|BPHI_PSESP 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|520924|emb|CAA54036| (X76500) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas sp.] Length = 346 Score = 46.1 bits (107), Expect = 4e-04 Identities = 31/115 (26%), Positives = 58/115 (49%), Gaps = 6/115 (5%) Query: 176 GVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGAR 233 G N + + D+ G P V + +++ + + E H H++ +AN+ A+E GA Sbjct: 161 GANCIYVTDSAGYMLPDDVKARLSAVRAALKPETELGFHGHHNLAMGVANSIAAIEAGAT 220 Query: 234 LIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDI-ENLVADAVE 287 ID + G+G G TP+ +A V A +++ + KI+D+ E+LV ++ Sbjct: 221 RIDAAAAGLGAGAGNTPMEVFIA---VCARMGIETGVDVFKIQDVSEDLVVPIMD 272 >gi|1389647|gnl|PID|d1013571 (D85853) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas pseudoalcaligenes] Length = 346 Score = 46.1 bits (107), Expect = 4e-04 Identities = 31/115 (26%), Positives = 58/115 (49%), Gaps = 6/115 (5%) Query: 176 GVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIEC--HFHNDTGCAIANAYTALEGGAR 233 G N + + D+ G P V + +++ + + E H H++ +AN+ A+E GA Sbjct: 161 GANCIYVTDSAGYMLPDDVKARLSAVRAALKPETELGFHGHHNLAMGVANSIAAIEAGAT 220 Query: 234 LIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDI-ENLVADAVE 287 ID + G+G G TP+ +A V A +++ + KI+D+ E+LV ++ Sbjct: 221 RIDAAAAGLGAGAGNTPMEVFIA---VCARMGIETGVDVFKIQDVAEDLVVPIMD 272 >gi|3322313 (AE001190) oxaloacetate decarboxylase, subunit alpha (oadA) [Treponema pallidum] Length = 593 Score = 45.7 bits (106), Expect = 6e-04 Identities = 22/85 (25%), Positives = 38/85 (43%) Query: 166 LNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAY 225 + + K + G + + I D G P Y+L+ +K V +E H H TG ++A Sbjct: 158 VELAKEYARFGADSICIKDMSGLLTPYGAYDLVSAIKKSVDLPVELHTHATTGMSVATLV 217 Query: 226 TALEGGARLIDVSVLGIGERNGITP 250 A E G +ID ++ + +P Sbjct: 218 KAAEAGVDVIDTAIASMSMGTSHSP 242 >gi|2127407|pir||I40725 2-isopropylmalate synthase (EC 4.1.3.12) - Corynebacterium glutamicum >gi|452382|emb|CAA50295| (X70959) 2-isopropylmalate synthase [Corynebacterium glutamicum] Length = 638 Score = 45.3 bits (105), Expect = 8e-04 Identities = 70/312 (22%), Positives = 111/312 (35%), Gaps = 35/312 (11%) Query: 30 LREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL----- 84 LR+G Q E+K + L G IE+ P AS+ I + G+ Sbjct: 96 LRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKGMIPDDV 155 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGKDMNYIAKSAVEVI 140 ++L R H+ + E + TS R D + K A + Sbjct: 156 TIQVLVQAREHL--IRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKVQVKKLATDAA 213 Query: 141 EFVKSKGIEI-------RFSSED------SFRSDLVDLLNIYKTVDKIGVNR--VGIADT 185 E +K+ + ++S E + ++VD + + +D N + + T Sbjct: 214 ELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDA--VVEVMDPTPENPMIINLPST 271 Query: 186 VGCANPRQVYELI----RTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLG 241 V P + I R L S + H HND G + A GA I+ + G Sbjct: 272 VEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFG 331 Query: 242 IGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCA 301 GER G L L M+ D + IR I + V ++ +P +P G Sbjct: 332 NGERTGNVCLVTLALNMLTQGVD---PQLDFTDIRQIRSTVEYCNQLRVPERHPYGGDLV 388 Query: 302 FTHKAGIHAKAI 313 FT +G H A+ Sbjct: 389 FTAFSGSHQDAV 400 >gi|1170768|sp|P42455|LEU1_CORGL 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM SYNTHETASE) Length = 616 Score = 45.3 bits (105), Expect = 8e-04 Identities = 70/312 (22%), Positives = 111/312 (35%), Gaps = 35/312 (11%) Query: 30 LREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL----- 84 LR+G Q E+K + L G IE+ P AS+ I + G+ Sbjct: 74 LRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKGMIPDDV 133 Query: 85 KAKILTHIRCHMDDAKVAVETXXXXXXXXI----GTSKFLRQYSHGKDMNYIAKSAVEVI 140 ++L R H+ + E + TS R D + K A + Sbjct: 134 TIQVLVQAREHL--IRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKVQVKKLATDAA 191 Query: 141 EFVKSKGIEI-------RFSSED------SFRSDLVDLLNIYKTVDKIGVNR--VGIADT 185 E +K+ + ++S E + ++VD + + +D N + + T Sbjct: 192 ELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDA--VVEVMDPTPENPMIINLPST 249 Query: 186 VGCANPRQVYELI----RTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLG 241 V P + I R L S + H HND G + A GA I+ + G Sbjct: 250 VEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFG 309 Query: 242 IGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCA 301 GER G L L M+ D + IR I + V ++ +P +P G Sbjct: 310 NGERTGNVCLVTLALNMLTQGVD---PQLDFTDIRQIRSTVEYCNQLRVPERHPYGGDLV 366 Query: 302 FTHKAGIHAKAI 313 FT +G H A+ Sbjct: 367 FTAFSGSHQDAV 378 >gi|1695643|gnl|PID|d1011901 (D78170) pyruvate carboxylase [Schizosaccharomyces pombe] Length = 1185 Score = 45.3 bits (105), Expect = 8e-04 Identities = 32/134 (23%), Positives = 63/134 (46%), Gaps = 4/134 (2%) Query: 166 LNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV-VSCDIECHFHNDTGCAIANA 224 +N+ + ++G++ +GI D G P+ LI ++ I H H+ G A+A+ Sbjct: 730 VNLVDKMVEMGIHILGIKDMAGVMKPKAARLLISAIREKHPELPIHVHTHDSAGTAVASM 789 Query: 225 YTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVAD 284 ALE GA ++DV+ +G+T A + + ++ +++R+I++ A Sbjct: 790 AAALEAGADVVDVAT---DSMSGLTSQPSFGAVLASVDGTDKQLEFDNNQLREIDSYWAQ 846 Query: 285 AVEVNIPFNNPITG 298 + PF + I G Sbjct: 847 MRLLYSPFESEIKG 860 Database: nr Posted date: Mar 13, 1999 7:20 PM Number of letters in database: 110,384,460 Number of sequences in database: 361,503 Lambda K H 0.318 0.135 0.386 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 87003164 Number of Sequences: 361503 Number of extensions: 3461204 Number of successful extensions: 9034 Number of sequences better than 1.0e-03: 77 Number of HSP's better than 0.0 without gapping: 57 Number of HSP's successfully gapped in prelim test: 20 Number of HSP's that attempted gapping in prelim test: 8825 Number of HSP's gapped (non-prelim): 98 length of query: 428 length of database: 110384460 effective HSP length: 57 effective length of query: 371 effective length of database: 89778789 effective search space: 33307930719 effective search space used: 33307930719 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.7 bits) S2: 104 (44.9 bits)