Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Posit Science Corporation University of California, San Francisco Case Western Reserve University |
---|---|
Information provided by: | Posit Science Corporation |
ClinicalTrials.gov Identifier: | NCT00505349 |
The overall goal of this study is to evaluate the impact of cognitive training on blood levels of neurotrophic factors in adults.
Condition | Intervention |
---|---|
Healthy |
Behavioral: Computer-based cognitive training |
Study Type: | Interventional |
Study Design: | Basic Science, Open Label, Uncontrolled, Parallel Assignment, Bio-availability Study |
Official Title: | Blood Neurotrophic Factors in Adults |
Estimated Enrollment: | 60 |
Study Start Date: | June 2007 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
Phase I: Closed: No Intervention
Phase I in this study will involve the evaluation of blood-derived neurotrophic factors in healthy, younger adults (18-30.) Individuals in this group will not undergo computerized, cognitive training.
|
|
Phase II: Open: Experimental
Phase II of this study will involve an evaluation of the pre- and post- cognitive training levels of blood-derived neurotrophic factors in healthy, mature adults.
|
Behavioral: Computer-based cognitive training
The experimental cognitive training program consists of a set of six interactive training exercises in which the participant listens to recorded sounds, including simple acoustic stimuli and continuous speech. The program is designed upon the principles of brain-plasticity, and, for the purposes of this study, is intended to be used for an 8-10 week period (40 total hours of training.)
|
Current research suggests that levels of brain-derived neurotrophic factor (BDNF) and certain excitatory neurotransmitters - specifically glutamate, D-serine, and glycine are low in participants with depression and other mental illnesses (Wolkowitz and Reus 2002, Tan et al., 2005; Shoval & Weizman, 2005; Hashimoto et al., 2005). Research also suggests that levels of both BDNF and excitatory transmitters can be enhanced by cognitive stimulation (Hynd et al., 2005; Wu et al., 2005; Yang et al., 2005; Mattson et al., 2004). BDNF is found in brain tissue and is also measurable in blood; it stimulates neuronal cell growth in certain brain regions (Duman, 2004). In Phase 1, we wish to measure the levels of specific neurotrophic factors in healthy, young participants. Phase 2 is intended to correlate similar levels with change in neurocognitive performance in healthy, older participants. Overall, this study is designed to obtain a raw measure of the impact that cognitive training has on the mature adult brain.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Phase 1: Closed
Phase 2: Open @ Case Western Reserve University-UHCMC
Exclusion Criteria:
Phase 1
Phase 2
Sensory/Motor Exclusions:
Psychiatric Exclusions:
Neurological Exclusions:
Medication Exclusions:
Additional Exclusions:
Contact: Karen M. McWhirter | 415-394-3100 | karen.mcwhirter@positscience.com |
Contact: Henry Mahncke, PhD | 415-394-3100 | henry.mahncke@positscience.com |
United States, California | |
Posit Science Corporation | Recruiting |
San Francisco, California, United States, 94104 | |
Contact: Karen M. McWhirter 415-394-3100 karen.mcwhirter@positscience.com | |
Contact: Henry W. Mahncke, PhD 415-394-3100 henry.mahncke@positscience.com |
Principal Investigator: | Henry Mahncke, PhD | Posit Science Corporation |
Responsible Party: | Posit Science ( Karen McWhirter, Clinical Monitor/Project Manager ) |
Study ID Numbers: | OUT-117-2005 |
Study First Received: | July 19, 2007 |
Last Updated: | April 17, 2008 |
ClinicalTrials.gov Identifier: | NCT00505349 |
Health Authority: | United States: Institutional Review Board |
neurotrophic factors cognitive status young adults |
mature adults neurotrophic factors cognitive training |
Healthy |