NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 Facility: Southern Research Institute Chemical CAS #: PESTFERTMIX2 Lock Date: 05/22/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + M + + + + I + + + + M + + + + + + + M | |__________________________________________________________________________| Gallbladder | + M M + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Inflammation, Subacute | 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + M + + + + + + + + + + + + M M + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Accessory Adrenal Cortical Nodule | X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Degeneration, Cystic | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + M + + + + | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Cystic | 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + | Hemorrhage | 1 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + I + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | M + + + + + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | 1 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Casts Protein | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 4 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 0| 1| 1| | | DAY ON TEST | 8| 8| 5| 8| 8| | | | 3| 3| 9| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | VEHICLE | 7| 7| 7| 7| 8| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 16 | |__________________________________________________________________________|____________| Gallbladder | | 18 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | Inflammation, Subacute | | 2 1.0| |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 17 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 0| 1| 1| | | DAY ON TEST | 8| 8| 5| 8| 8| | | | 3| 3| 9| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | VEHICLE | 7| 7| 7| 7| 8| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | | 19 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 19 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Degeneration, Cystic | | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | | 19 | |__________________________________________________________________________|____________| Ovary | | 20 | |__________________________________________________________________________|____________| Uterus | | 20 | Hyperplasia, Cystic | | 4 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 19 | Hemorrhage | | 1 1.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 0| 1| 1| | | DAY ON TEST | 8| 8| 5| 8| 8| | | | 3| 3| 9| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | VEHICLE | 7| 7| 7| 7| 8| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node, Mesenteric | | 19 | |__________________________________________________________________________|____________| Spleen | | 19 | Hematopoietic Cell Proliferation | | 1 1.0| |__________________________________________________________________________|____________| Thymus | | 19 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 0| 1| 1| | | DAY ON TEST | 8| 8| 5| 8| 8| | | | 3| 3| 9| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | VEHICLE | 7| 7| 7| 7| 8| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | | 20 | Casts Protein | | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0.1X | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + M + + + + + + | |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Inflammation, Subacute | 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | Cyst | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + M + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0.1X | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Accessory Adrenal Cortical Nodule | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + | Cyst | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Degeneration, Cystic | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + M + + | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + | Angiectasis | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Cystic | 1 1 2 2 2 2 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 0.1X | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Casts Protein | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 11 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 0.1X | 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 19 | |__________________________________________________________________________|____________| Gallbladder | | 20 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | Inflammation, Subacute | | 1 1.0| |__________________________________________________________________________|____________| Pancreas | | 20 | Cyst | | 1 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 19 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 0.1X | 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Heart | | 20 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 19 | Cyst | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | | 19 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Degeneration, Cystic | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | | 19 | |__________________________________________________________________________|____________| Ovary | | 20 | Angiectasis | | 1 3.0| |__________________________________________________________________________|____________| Uterus | | 20 | Hyperplasia, Cystic | | 9 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 0.1X | 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 0.1X | 0| 0| 0| 0| 1| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | Casts Protein | | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1X | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + M + + + + + + + + + + + + + | |__________________________________________________________________________| Gallbladder | + + + + + + + + I + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Inflammation, Subacute | 1 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1X | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Accessory Adrenal Cortical Nodule | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + M + + + + + + + + + + + | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Degeneration, Cystic | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Cystic | 1 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 1 | Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1X | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Casts Protein | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 18 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 1X | 3| 3| 3| 3| 4| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 19 | |__________________________________________________________________________|____________| Gallbladder | | 19 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | Inflammation, Subacute | | 2 1.5| |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 20 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 1X | 3| 3| 3| 3| 4| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 18 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Degeneration, Cystic | | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | | 20 | |__________________________________________________________________________|____________| Ovary | | 20 | |__________________________________________________________________________|____________| Uterus | | 20 | Hyperplasia, Cystic | | 8 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | Hemorrhage | | 1 1.0| Hyperplasia, Lymphoid | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 1X | 3| 3| 3| 3| 4| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 19 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 1X | 3| 3| 3| 3| 4| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | | 20 | Casts Protein | | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 5| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 1| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10X | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + M + + M + + + + + | |__________________________________________________________________________| Gallbladder | M M + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Inflammation, Subacute | 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | Erosion | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 5| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 1| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10X | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Accessory Adrenal Cortical Nodule | X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | Cyst | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Degeneration, Cystic | 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + M + M + + + + + + + + + + + + + + | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Cystic | 2 1 1 2 2 1 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 0| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| 5| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 1| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10X | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | Inflammation, Subacute | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Casts Protein | 1 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 25 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 10X | 6| 6| 6| 6| 7| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 18 | |__________________________________________________________________________|____________| Gallbladder | | 18 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 19 | |__________________________________________________________________________|____________| Liver | | 20 | Inflammation, Subacute | | 1 1.0| |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | Erosion | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 20 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 10X | 6| 6| 6| 6| 7| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 20 | Cyst | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Degeneration, Cystic | | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | | 18 | |__________________________________________________________________________|____________| Ovary | | 20 | |__________________________________________________________________________|____________| Uterus | | 20 | Hyperplasia, Cystic | | 9 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 10X | 6| 6| 6| 6| 7| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | Inflammation, Subacute | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 10X | 6| 6| 6| 6| 7| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | | 20 | Casts Protein | | 2 1.0| |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100X | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + | |__________________________________________________________________________| Gallbladder | + + M + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Accessory Adrenal Cortical Nodule | X X X | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100X | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Degeneration, Cystic | 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + | Hyperplasia, Cystic | 2 2 2 2 2 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | 1 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100X | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 32 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 3| | A | 100X | 9| 9| 9| 9| 0| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 19 | |__________________________________________________________________________|____________| Gallbladder | | 19 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 20 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 3| | A | 100X | 9| 9| 9| 9| 0| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 20 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Degeneration, Cystic | | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | | 20 | |__________________________________________________________________________|____________| Ovary | | 20 | |__________________________________________________________________________|____________| Uterus | | 20 | Hyperplasia, Cystic | | 8 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 19 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 3| | A | 100X | 9| 9| 9| 9| 0| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Spleen | | 20 | Hematopoietic Cell Proliferation | | 1 1.0| |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 3| | A | 100X | 9| 9| 9| 9| 0| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + I + + + M + + + + + + + + + + | |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Accessory Adrenal Cortical Nodule | X X | Hypertrophy, Focal | 1 | __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + | Cyst | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + M I + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | Dilatation | 3 | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | Hematopoietic Cell Proliferation | 2 | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Thymus | M + I + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 39 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | VEHICLE | 2| 2| 2| 2| 3| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 18 | |__________________________________________________________________________|____________| Gallbladder | | 20 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 20 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | VEHICLE | 2| 2| 2| 2| 3| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 2 | Hypertrophy, Focal | | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 19 | Cyst | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | | 18 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | | 20 | |__________________________________________________________________________|____________| Preputial Gland | | 20 | |__________________________________________________________________________|____________| Prostate | | 20 | |__________________________________________________________________________|____________| Seminal Vesicle | | 20 | Dilatation | | 1 3.0| |__________________________________________________________________________|____________| Testes | | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | VEHICLE | 2| 2| 2| 2| 3| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | Hematopoietic Cell Proliferation | | 1 2.0| |__________________________________________________________________________|____________| Thymus | | 18 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | VEHICLE | 2| 2| 2| 2| 3| | L | CONTROL | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 4| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.1X | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + M + + + + + + + + + + + + + + + | |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | Lobules, Necrosis | 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | Cyst | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 4| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.1X | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Accessory Adrenal Cortical Nodule | X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 2 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | Cyst | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic | 2 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 4| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.1X | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Spleen | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Casts Protein | 1 | Renal Tubule, Regeneration | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 46 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0.1X | 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 19 | |__________________________________________________________________________|____________| Gallbladder | | 20 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 19 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | Lobules, Necrosis | | 1 1.0| |__________________________________________________________________________|____________| Pancreas | | 20 | Cyst | | 1 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 20 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0.1X | 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | Hyperplasia | | 3 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | | 20 | Cyst | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | | 20 | |__________________________________________________________________________|____________| Preputial Gland | | 20 | Inflammation, Chronic | | 1 2.0| |__________________________________________________________________________|____________| Prostate | | 20 | |__________________________________________________________________________|____________| Seminal Vesicle | | 20 | |__________________________________________________________________________|____________| Testes | | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0.1X | 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Bone Marrow | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0.1X | 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | Casts Protein | | 1 1.0| Renal Tubule, Regeneration | | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1X | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + M + + + + + + | |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | Erosion | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + M + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Accessory Adrenal Cortical Nodule | X | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1X | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + M + + M + + + + + + + + | |__________________________________________________________________________| Pituitary Gland | + + + + + + + M + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Ectopic Thymus | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + I + + + + + | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | Pigmentation, Hemosiderin | 2 | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1X | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | Alveolar Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | Renal Tubule, Regeneration | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 53 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 1X | 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 19 | |__________________________________________________________________________|____________| Gallbladder | | 20 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 19 | |__________________________________________________________________________|____________| Liver | | 20 | |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | Erosion | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 19 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 1X | 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | | 17 | |__________________________________________________________________________|____________| Pituitary Gland | | 19 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Ectopic Thymus | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | | 20 | |__________________________________________________________________________|____________| Preputial Gland | | 20 | |__________________________________________________________________________|____________| Prostate | | 19 | |__________________________________________________________________________|____________| Seminal Vesicle | | 20 | |__________________________________________________________________________|____________| Testes | | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 1X | 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | Pigmentation, Hemosiderin | | 1 2.0| |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | Alveolar Epithelium, Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 1X | 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | Renal Tubule, Regeneration | | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10X | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | Necrosis | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | Erosion | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10X | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Accessory Adrenal Cortical Nodule | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 2 3 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Follicle, Cyst | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10X | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 60 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 10X | 1| 1| 1| 1| 2| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 20 | |__________________________________________________________________________|____________| Gallbladder | | 20 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 19 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | |__________________________________________________________________________|____________| Pancreas | | 20 | Necrosis | | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | | 20 | |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | Erosion | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 20 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 10X | 1| 1| 1| 1| 2| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | Hyperplasia | | 3 2.3| |__________________________________________________________________________|____________| Parathyroid Gland | | 19 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Follicle, Cyst | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | | 20 | |__________________________________________________________________________|____________| Preputial Gland | | 20 | |__________________________________________________________________________|____________| Prostate | | 20 | |__________________________________________________________________________|____________| Seminal Vesicle | | 20 | |__________________________________________________________________________|____________| Testes | | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 10X | 1| 1| 1| 1| 2| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 19 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | Hemorrhage | | 1 2.0| |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 10X | 1| 1| 1| 1| 2| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 1| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100X | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + M + | |__________________________________________________________________________| Gallbladder | + I + + + + + + + I + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | M + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | Accessory Adrenal Cortical Nodule | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 1| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100X | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | Cyst | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | Ectopic Thymus | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 _____________________________________________________________________________________________________________________ | 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| DAY ON TEST | 8| 1| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 100X | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | __________________________________________|__________________________________________________________________________ Page 67 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 100X | 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | | 19 | |__________________________________________________________________________|____________| Gallbladder | | 18 | |__________________________________________________________________________|____________| Intestine Large, Colon | | 20 | |__________________________________________________________________________|____________| Intestine Large, Rectum | | 20 | |__________________________________________________________________________|____________| Intestine Large, Cecum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | | 20 | |__________________________________________________________________________|____________| Intestine Small, Ileum | | 20 | |__________________________________________________________________________|____________| Liver | | 20 | |__________________________________________________________________________|____________| Pancreas | | 20 | |__________________________________________________________________________|____________| Salivary Glands | | 20 | |__________________________________________________________________________|____________| Stomach, Forestomach | | 20 | |__________________________________________________________________________|____________| Stomach, Glandular | | 20 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 19 | |__________________________________________________________________________|____________| Heart | | 20 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 100X | 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | | 20 | Accessory Adrenal Cortical Nodule | | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | | 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | | 20 | |__________________________________________________________________________|____________| Parathyroid Gland | | 20 | Cyst | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | | 20 | |__________________________________________________________________________|____________| Thyroid Gland | | 20 | Ectopic Thymus | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | | 20 | |__________________________________________________________________________|____________| Preputial Gland | | 20 | |__________________________________________________________________________|____________| Prostate | | 20 | |__________________________________________________________________________|____________| Seminal Vesicle | | 20 | |__________________________________________________________________________|____________| Testes | | 20 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | | 20 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 100X | 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | | 20 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | | 20 | |__________________________________________________________________________|____________| Spleen | | 20 | |__________________________________________________________________________|____________| Thymus | | 20 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | | 20 | |__________________________________________________________________________|____________| Skin | | 20 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | | 20 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | | 20 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | | 20 | |__________________________________________________________________________|____________| Nose | | 20 | |__________________________________________________________________________|____________| Trachea | | 20 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 70 NTP Experiment-Test: 89009-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 26-WEEK PESTICIDE/FERTILIZER CONTAMINATION--MIXTURE 2 Date: 10/18/04 Route: DOSED WATER Time: 10:25:13 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| | | DAY ON TEST | 8| 8| 8| 8| 8| | | | 3| 3| 3| 3| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 100X | 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | | 20 | |__________________________________________________________________________|____________| Urinary Bladder | | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------