Greenberg, Norman M., Ph.D.
CA84296- Transgenic Mouse Models of Prostate Cancer
The long term goal of this application is to exploit the collective
experience of a critical mass of investigators at Baylor College of
Medicine and Texas A&M University to initiate, develop and characterize
transgenic and knockout "germ line" mouse models of prostate cancer as a component of the National Cancer Institute Mouse Models of Human Cancer Consortium. Building on our expertise and proven track record in the
successful application of transgenic mouse models and genetic perturbation analysis to the field of prostate cancer research, the joint Baylor
College of Medicine and Texas A&M University groups (BCM-TAMU)
propose to accomplish the following tasks:
Task 1. continue to develop, characterize, validate and
disseminate the spontaneous autochthonous TRansgenic Adenocarcinoma
of Mouse Prostate (TRAMP) mouse model of prostate cancer;
Task 2. develop, characterize, validate and disseminate novel spontaneous autochthonous transgenic and knock-out mouse models of
prostate cancer;
Task 3. develop, characterize, validate and disseminate novel technologies pertaining to the generation of appropriate transgenic and
knock-out models for prostate cancer research;
Task 4. develop, characterize, validate and disseminate novel information technologies pertaining to the efficient generation, husbandry, maintenance and analysis of transgenic and knock-out models and the
management of associated data sets; and
Task 5. otherwise contribute to the collective efforts and
mission of the MMHC and the cancer research community at large through
the free and timely exchange of ideas, skills, data and research materials.
It is anticipated that the collective experience and resources of the
BCM-TAMU group will, through participation in The Mouse Models of Human
Cancer Consortium, greatly facilitate and compliment the stategic aims of
this National Cancer Institute initiative.
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