Mathur A, Contractor T, Mathur A, Kishoria N, Kotru S, Baweja S; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. B10333.
S N Medical College, Jodhpur, India
ISSUES: Renal failure is observed in patients infected with the human immunodeficiency virus (HIV). Underlying glomerular disease and disturbances in renal tubular function predispose them to a number of hemodynamic and nephrotoxic insults. Prerenal azotemia due to depletion of intravascular volume is the most common cause of acute renal insufficiency in patients infected with HIV. In present study clinical features of patients with renal failure have been analysed. DESCRIPTION: The patients admitted with the Medicine Unit providing hospital based HIV care at M D M Hospital, Jodhpur since January,2000 have been included in the present analysis. 6 males out of 42 symptomatic HIV patients in the age group of 25 - 50 years showed evidence of renal impairment. The presenting symptoms were Fever, Shortness of breath, Oliguria, Pedal odema and facial puffiness and anorexia. Clinical evaluation revealed hypertension in one patient along with presence of infections like Pulmonary Tuberculosis in 2, Pneumocystis carinii Pneumonia in1, Diarrhoea in 2 and Septicaemia in 1.Urine analysis revealed minimal proteinuria with leucocytes and cast. One patient showed evidence of microscopic hematuria also. Ultrasound examination showed loss of corticomedullary differentiation of the kidneys in 4 patients, hepatosplenomegaly with bilateral effusion in 1 and normal scan in 1 patient. 5 patients had mild renal impairment with creatinine in the range of 2 - 4mg% while one patient had moderate renal failure with creatinine level of 6mg%. LESSONS LEARNED: 5 of these patients had renal impairment secondary to septicaemia, haemodynamic changes and nephrotoxic antibiotics, one patient had clinical features and urinary finding suggestive of glomerulonephritis though renal biopsy was not performed. RECOMMENDATIONS: Renal functions need to be monitored in HIV/AIDS patients and potentially reversible factors to be identified and managed.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Creatinine
- Glomerulonephritis
- HIV Infections
- HIV Seropositivity
- Humans
- India
- Kidney
- Kidney Diseases
- Kidney Failure
- Kidney Failure, Acute
- Male
- Pneumonia, Pneumocystis
- Proteinuria
- Uremia
Other ID:
UI: 102256138
From Meeting Abstracts