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Sponsored by: |
Department of Veterans Affairs |
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Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00827268 |
This study offers 60 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading. The overall time commitment for participation in this study is approximately 10-12 weeks.
Condition | Intervention | Phase |
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Aphasia Stroke Dyslexia, Acquired |
Behavioral: One-on-one treatment of reading difficulties Radiation: Functional Magnetic Resonance Imaging (fMRI) |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Single Group Assignment, Efficacy Study |
Official Title: | Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes |
Estimated Enrollment: | 18 |
Study Start Date: | March 2009 |
Estimated Study Completion Date: | December 2012 |
Estimated Primary Completion Date: | March 2012 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental
Adults with post-stroke reading difficulties (phonological alexia), >3 months post-stroke, native English speakers, able to undergo an MRI scan.
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Behavioral: One-on-one treatment of reading difficulties
Multimodal behavioral treatment focused on retraining sound to letter associations and skills in sounding out words when reading. Treatment has been pilot-tested in published papers since 1998.
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2: Experimental
fMRI during reading pseudowords and during repeating pseudowords, as well as finger tapping (non-language task)
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Radiation: Functional Magnetic Resonance Imaging (fMRI)
fMRI during reading pseudowords and during repeating pseudowords, as well as finger tapping (non-language task).
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The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group elements) design with 60 hours of a modified multi-modal treatment of alexia replicated across 18 adults with post-stroke phonological alexia. The short-term goals of this research proposal include the following: 1) determine if a modified multimodal treatment of phonological alexia can improve pseudoword reading skills (providing a basis from which training will also treat real word reading skills), 2) determine if a modified multimodal treatment of phonological alexia can improve real word reading skills, 3) determine how brain lesion extent and location relate to participants' response to treatment, and 4) identify relationships between changes in functional brain activity in specified regions of interest and participants' response to treatment.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Timothy W Conway, PhD | (352) 376-1611 ext 5395 | twc@phhp.ufl.edu |
United States, Florida | |
North Florida/South Georgia Veterans Health System | |
Gainesville, Florida, United States, 32608 |
Principal Investigator: | Timothy W. Conway, PhD | North Florida/South Georgia Veterans Health System |
Responsible Party: | Department of Veterans Affairs ( Conway, Timothy - Principal Investigator ) |
Study ID Numbers: | B6699W, B6698W |
Study First Received: | January 20, 2009 |
Last Updated: | January 23, 2009 |
ClinicalTrials.gov Identifier: | NCT00827268 |
Health Authority: | United States: Federal Government |
Dyslexia Reading Aphasia Stroke |
Dyslexia, Acquired Speech Disorders Cerebral Infarction Aphasia Stroke Vascular Diseases Central Nervous System Diseases Dyslexia Language Disorders Learning Disorders Brain Diseases |
Cerebrovascular Disorders Cognition Disorders Signs and Symptoms Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders Mental Disorders Diagnosed in Childhood Neurologic Manifestations Dementia Neurobehavioral Manifestations Delirium Communication Disorders |
Nervous System Diseases Cardiovascular Diseases |