Outcomes in Trials ofAntibacterial Drugs for AOM

• Clinical: Symptomatic improvement, or symptomatic & otoscopic improvement, etc.

• Bacteriologic: eradication of bacteria

• Bacteriologic/Clinical: Clinical improvement plus eradication of bacteria in clinical failures

• During Therapy

• End of Therapy

• After Therapy

Choice of Outcome

Timing of Outcome

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