Kimura S, Masuo M, Ryu T, Oka S, Mori S; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 101 (abstract no. Mo.B.1271).
Social Health Insurance Medical Center, Tokyo, Japan.
Case Report: Forty-six year-old HIV-positive homosexual man presented with DCM-like symptoms and acute cardiac failure in December, 1994. He had a history of Pneumocystis carinii pneumonia two years ago, which was successfully treated with Co-trimoxazole and pentamidine. Cardiac failure was controlled with diuretica and digitalis preparation, and zidovudine and didanosine were started. In July, 1995, he admitted to our hospital because of severe dyspnea and palpitation. On admission his heart rate was 124/min (reg), ECG; ST-T change in I, II aVL, aVF, V4-V6, CTR; 50%. Echocardiogram revealed severe hypokinesis in anteroseptal region. EF was 20%. Other findings were; CAG, normal; myocardial scintigram, defect in anteroseptal region; CD4 count, 27/microliter; CMV antigenemia, (+). Myocardial biopsy disclosed numerous cytomegalic inclusion bodies which were positively stained with monoclonal antibody against CMV-EA. His cardiac function partially recovered by treatment with diuretica and digitalis preparation. In October 1995, ganciclovir administration was started because CMV retinitis was detected. The administration of ganciclovir seemed to have no effect on his cardiac function. Conclusion: CMV myocarditis was confirmed by myocardial biopsy. Administration of ganciclovir, several months after the onset of myocarditis, showed no effect on cardiac function, suggesting the necessity of early diagnosis (biopsy) and treatment of CMV myocarditis.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Biopsy
- CD4 Lymphocyte Count
- Cytomegalovirus Retinitis
- Electrocardiography
- Ganciclovir
- Heart Failure
- Humans
- Male
- Myocarditis
- Myocardium
- Zidovudine
Other ID:
UI: 102217234
From Meeting Abstracts