| US 7,399,774 B2 | ||
| 6-substituted nicotinamide derivatives as opioid receptor antagonists | ||
| Miles Goodman Siegel, Indianapolis, Ind. (US); Russell Dean Stucky, Indianapolis, Ind. (US); and Kumiko Takeuchi, Indianapolis, Ind. (US) | ||
| Assigned to Eli Lilly and Company, Indianapolis, Ind. (US) | ||
| Appl. No. 10/546,521 PCT Filed Feb. 25, 2004, PCT No. PCT/US2004/003360 § 371(c)(1), (2), (4) Date Aug. 19, 2005, PCT Pub. No. WO2004/080968, PCT Pub. Date Sep. 23, 2004. |
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| Claims priority of provisional application 60/453414, filed on Mar. 07, 2003. | ||
| Prior Publication US 2006/0205715 A1, Sep. 14, 2006 | ||
| Int. Cl. C07D 211/72 (2006.01); A61K 31/44 (2006.01) | ||
| U.S. Cl. 514—350 [546/298] | 2 Claims |
| 1. A compound selected from the group consisting of:
6-(8-Pentylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-nicotinamide,
6-(5-Pentylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-nicotinamide,
6-(5-Pentylamino-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-nicotinamide,
6-(1-Pentylamino-indan-5-yloxy)-nicotinamide,
6-(1-Pentylamino-indan-4-yloxy)-nicotinamide,
6-(8-Benzylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-nicotinamide,
6-(5-Benzylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-nicotinamide,
6-(5-Benzylamino-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-nicotinamide,
6-(1-Benzylamino-indan-4-yloxy)-nicotinamide,
6-(8-Phenethylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-nicotinamide,
6-(5-Phenethylamino-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-nicotinamide,
6-(5-Phenethylamino-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-nicotinamide,
6-(1-Phenethylamino-indan-4-yloxy)-nicotinamide,
6-{8-[2-(3-Fluoro-phenyl)-ethylamino]-5,6,7,8-tetrahydro-naphthalen-2-yloxy}-nicotinamide, or a pharmaceutically acceptable salt or solvate thereof.
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