Damania K, Merchant RH, Arwari S, Gilada IS, Karkare J; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 406 (abstract no. 23324).

Nowrosjee Wadia Maternity Hospital, Bombay, India.

OBJECTIVES: To study the efficacy of three pronged intervention strategy to reduce perinatal transmission of HIV 1 infection. DESIGN: Prospective, interventional study. METHODS: Interventional strategy in the form of antepartum zidovudine (ZDV) in a dosage of 100 mgs. qds for at least 7 weeks prior to delivery, elective caesarean section at term and no breast feeding (ZDV to infant for 6 weeks) was studied prospectively in 45 women accepting the same. Their babies were folowed-up clinically regularly and with HIV antibody testing at 9 months, 1 year, 15 months and 18 months interval. RESULTS: Of 40 women not accepting any interventional; 13 children remained seropositive at the end of 18 months. A transmission rate of 32.5% for our populance. Of the 18 babies who till date have followed up beyond 18 months; NO child has remained seropositive. All have become seronegative by 18 months. CONCLUSION: A three pronged intervention strategy to attack all periods of transmission in pregnancy (antenatal, intrapartum & postpartum) appears to be extremely effective. Antenatal ZDV in lower dosage and shorter period (at least 7 weeks) may be utilized in resource setting as in India amongst women offered and accepting the same.

Publication Types:

• Meeting Abstracts

Keywords:

• Breast Feeding
• Cesarean Section
• Child
• Delivery, Obstetric
• Disease Transmission, Vertical
• Female
• HIV Antibodies
• HIV Infections
• Humans
• India
• Infant
• Mothers
• Pharmaceutical Preparations
• Pregnancy
• Prospective Studies
• Zidovudine
• surgery
• transmission

Other ID:

• 98395354

UI: 102228954

From Meeting Abstracts