Damania K, Merchant RH, Arwari S, Gilada IS, Karkare J; International Conference on AIDS.
Int Conf AIDS. 1998; 12: 406 (abstract no. 23324).
Nowrosjee Wadia Maternity Hospital, Bombay, India.
OBJECTIVES: To study the efficacy of three pronged intervention strategy to reduce perinatal transmission of HIV 1 infection. DESIGN: Prospective, interventional study. METHODS: Interventional strategy in the form of antepartum zidovudine (ZDV) in a dosage of 100 mgs. qds for at least 7 weeks prior to delivery, elective caesarean section at term and no breast feeding (ZDV to infant for 6 weeks) was studied prospectively in 45 women accepting the same. Their babies were folowed-up clinically regularly and with HIV antibody testing at 9 months, 1 year, 15 months and 18 months interval. RESULTS: Of 40 women not accepting any interventional; 13 children remained seropositive at the end of 18 months. A transmission rate of 32.5% for our populance. Of the 18 babies who till date have followed up beyond 18 months; NO child has remained seropositive. All have become seronegative by 18 months. CONCLUSION: A three pronged intervention strategy to attack all periods of transmission in pregnancy (antenatal, intrapartum & postpartum) appears to be extremely effective. Antenatal ZDV in lower dosage and shorter period (at least 7 weeks) may be utilized in resource setting as in India amongst women offered and accepting the same.
Publication Types:
Keywords:
- Breast Feeding
- Cesarean Section
- Child
- Delivery, Obstetric
- Disease Transmission, Vertical
- Female
- HIV Antibodies
- HIV Infections
- Humans
- India
- Infant
- Mothers
- Pharmaceutical Preparations
- Pregnancy
- Prospective Studies
- Zidovudine
- surgery
- transmission
Other ID:
UI: 102228954
From Meeting Abstracts