DAVID Gene Report
2864986
interleukin 3 (colony-stimulating factor, multiple) Related Genes Homo sapiens
SP_COMMENT
function:Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.,
function:This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.,
similarity:Belongs to the IL-3 family.,
subcellular location:Secreted.,
subunit:Monomer.,
tissue specificity:Activated T-cells, mast cells, natural killer cells.,
REFSEQ_PROTEIN
NP_000579 ,
ENTREZ_GENE_SUMMARY
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.,
REFSEQ_MRNA
NM_000588 ,
GENPEPT_ACCESSION
AAA35725 ,
AAA59146 ,
AAA59147 ,
AAC08706 ,
AAH66272 ,
AAH66273 ,
AAH66274 ,
AAH66275 ,
AAH66276 ,
AAH69472 ,
AAK38378 ,
EAW62354 ,
Genomic_DNA ,
mRNA ,
GENE_SYMBOL
IL3 ,
GENE_NAME
Colony-stimulating factor, multiple,
Hematopoietic growth factor,
IL-3,
Interleukin 3,
Interleukin 3,,
Interleukin-3 precursor,
Interleukin-3 precursor (IL-3) (Multipotential colony-stimulating factor) (Hematopoietic growth factor) (P-cell-stimulating factor) (Mast cell growth factor) (MCGF),
MCGF,
Mast cell growth factor,
Multipotential colony-stimulating factor,
P-cell-stimulating factor,
interleukin 3 (colony-stimulating factor, multiple),
GENERIF_SUMMARY
binding kinetics of native IL-3 and several variants to IL-3 receptor ,
IL-3 induces MHC class II and B7.2 expression on eosinophils and renders them capable of supporting T cell proliferation to superantigen and antigen-derived peptides. ,
inhibition of signaling by antisense oligodeoxynucleotides targeting the common beta chain of receptors ,
ectopically expressed in myeloid leukemic cells with t(5;12)(q31;p13), suggesting that expression of IL3 was deregulated by the translocation, indicating a variant leukemogenic mechanism for translocations involving the 5' end of ETV6 ,
Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. ,
Monocytes cultured in the presence of IL-3 (plus IL-4) differentiate into dendritic cells that produce less IL-12 and shift T helper (Th) cell responses toward a Th2 cytokine pattern. ,
Data suggest that increased activity of mutated interleukin 3 is due to a change from a rare ligand to a common one, allowing the increase in IL-3-dependent signaling. ,
role in potentiating hematopoietic cell migration ,
The IL-3 gene is regulated by two enhancers that have distinct but overlapping tissue specificities. ,
WEHI-3B-derived IL-3 stimulation of mcl-1 gene transcription through the SIE motif involves phosphorylation of PU.1 at serine 142 by a p38(MAPK)-dependent pathway. ,
Incubation of eosinophils with IL-3 leads to reduced expression of IL-5R alpha which is sustained for up to 5 days; in contrast, expression of IL-3R alpha is increased by IL-3, whereas GM-CSF receptor alpha expression in eosinophils is unaffected by IL-3. ,
induces cell cycle progression via internal ribosome entry site-mediated translation of c-myc though the PI3K pathway in human factor-dependent leukemic cells ,
expression of alleles of the genes encoding IL-2, IL-3, IL-4, and IL-13 in CD4(+) T cell clones ,
IL-3 plays important roles in local eosinophil activation ,
Hematopoietin receptor superfamily. Comprised of cytokine-specific alpha chain and common beta chain for signaling. Contributes to differentiation and function of leukocytes. Protective immunity and pathophysiology of immunologic diseases. Review. ,
increased IL-3 levels in the bone marrow microenvironment of MM patients with imbalanced AML-1A and AML-1B expression can increase bone destruction and tumor cell growth. ,
long-term exposure of primitive human hematopoietic cells to elevated levels of human IL-3, GM-CSF and SF in vivo may deleteriously affect the stem cell compartment, while expanding terminal myelopoiesis. ,
ability of TGF-beta1 to polarize the differentiation of HPCs induced by IL-3 towards LC development, although IL-3 DCs were unable to form BGs partly because of their poor ability to induce Langerin. ,
positive immunostaining for IL-3 by TILs in 'in situ' breast cancers sustains the possibility that early in tumor development, IL-3 can contribute to the chronic immaturity of these vessels ,
Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains ,
The IL3 regulates the growth and differentiation of hematopoietic progenitor cells and functionally activates mature neutrophils or macrophages. ,
Endogenous IL-3 is required to maintain the lymphatic endothelial cell (LEC) phenotype in culture, and the addition of IL-3 to dermal blood endothelial cells (BEC) appears to induce transdifferentiation of BEC into LEC. ,
CD45+ cells were required for the capacity of IL-3 to inhibit osteoblast differentiation. IL-3 plays a dual role in the bone destructive process in myeloma by both stimulating osteoclasts and indirectly inhibiting osteoblast formation ,
Multiple logistic regression revealed a significant association between the appearance of nucleated RBCs in the blood and erythropoietin, IL-3, IL-6, and age. ,
Expression of CD48 on human peripheral blood eosinophils is regulated by interleukin (IL)-3. ,
In this paper provide the evidence that multiple single nucleotide polymorphisms in and around interleukin 3 (IL3) are associated with the disease in the Irish. ,
IL-3 can not replace GM-CSF to induce the differentiation of human monocytes into Langerhans cells in culture ,
About 18% of Indian subjects studied showed non histamine-releaser phenotype & also had reduced Lyn & Syk kinase expression. Non-releasers have also shown less potent isoform of IL-3/P8, which is suspected to be responsible for non-releaser phenotype ,
IL-3 is a central inducer of CD69 expression, while antigen is an enhancing factor acting on basophils cooperatively with IL-3. ,
IL-3-induced upregulation of CD203c is a late event and is not accompanied by upregulation of CD63. ,
CHROMOSOME
5,
ENTREZ_GENE_ID
3562 ,
PIR_SUMMARY
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.,
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.,
UNIGENE
Hs.694 ,
UNIREF100_ID
UniRef100_P08700 ,
PIR_NREF_ID
NF00091206,
NF00107111,
NF01682917,
NF01685652,
UNIPROT_ID
IL3_HUMAN ,
Q6GS87_HUMAN ,
Q6NZ78_HUMAN ,
Q6NZ79_HUMAN ,
CYTOBAND
5q31.1,
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