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HPV Chemical List History
 |
Note: EPA no longer updates this information, but it may be useful as a reference or resource |
October 9, 1998
The U.S. high production volume (HPV) chemicals are those which are manufactured
in or imported into the United States in amounts equal to or greater than
one million pounds per year. The U.S. HPV chemicals were identified through
information collected under the Toxic Substances Control Act (TSCA) Inventory
Update Rule (IUR). Organic chemicals that are manufactured in, or imported
into, the United States in amounts equal to or exceeding 10,000 pounds
per year are subject to reporting under the TSCA IUR. Reporting is required
every four years.
The HPV Challenge Program Chemical List consists of all the HPV chemicals
reported during the 1990 IUR reporting year. Inorganic chemicals and polymers,
except in special circumstances, were not subject to the IUR reporting
requirements although a number were reported in error. The HPV Challenge
Program Chemical List contains about 2,800 chemicals.
The 1990 IUR list was selected as the starting point for this program.
As subsequent reporting years identify additional chemicals (including
inorganics, once the corresponding reporting requirements have been added
under the IUR), they will be posted here for information purposes. EPA
expects that, over time, the testing of new HPV chemicals will become
routine, and companies may wish to test new HPV chemicals as they appear.
In keeping with that eventual goal, EPA is posting the 1994 IUR List of
HPV Additions, which contains about 500 organic HPV chemicals which were
newly reported as HPV in the 1994 IUR and are thus not part of the HPV
Challenge Program at this time. This list is being provided particularly
for use by companies who desire to propose categories of chemicals for
testing and wish to include chemicals from the 1994 list in their category
definitions.
Each HPV chemical list is provided in database format. The database tables
contain one record per chemical. Each record contains three fields. The
first field (CASNO) contains the Chemical Abstract Services registry number,
which is a unique identification number assigned to a chemical. The second
field (INDICATOR) is an indicator variable that, if greater than 0, signifies
that the chemical falls outside the scope of the HPV Challenge Program.
The possible values for the indicator and their corresponding reasons
for falling outside the scope of the program are:
1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties, or
Finally, the name of the chemical is found in the last field (CHEMICAL).
December
9, 1998
The scope of the HPV Challenge Program does not include testing of polymers
and inorganic chemicals. These substances were excluded from the reporting
requirements of the Inventory Update Rule (IUR) of 1986 unless regulated
by a TSCA Section 4, 5(a)(2), 5(b)(4) or 6 rule or an order under Section
5(e) or 5(f), as stipulated under 40 CFR 710.26. To maintain consistency
within the HPV Challenge Program, however, the Agency decided it would
not include any polymers or inorganics in the program. Since the HPV Challenge
Program Chemical List was derived from the 1990 IUR, it was expected that
only a minimal number of these substances would be on the list, and that,
in most cases, those inclusions would be the result of misreporting by
individual companies.
In preparing the HPV Challenge Program Chemical List, the Agency reviewed
the original 1990 IUR list of HPV chemicals for polymers and inorganics
(misreported and appropriately reported). This review utilized a computer
algorithm that, as noted by the Agency in the preamble to the 1986 IUR,
would not identify all polymers and inorganic substances on the list,
due to the highly complex nature of the CAS nomenclature rules and the
lack of a complete molecular formula for many of the Class 2 substances
on the TSCA Inventory. Because of the limitations of the screening algorithm,
some polymers and inorganic chemicals did escape the automatic search
and did appear on the first HPV Challenge Program Chemical List, which
was published on October 9, 1998.
In response to questions regarding the polymers and inorganics that appeared
on the initial HPV Challenge Program Chemical List, the Agency conducted
a comprehensive manual review of the list. A similar exercise was conducted
on the 1994 IUR List of HPV Additions. As a result of this effort, additional
polymers and inorganic substances have been identified and removed from
the scope of the HPV Challenge Program.
To avoid any potential confusion from having multiple lists of HPV Challenge
Program chemicals, the Agency is not removing these chemicals from the
original list, but rather is marking them with an indicator of "3" to
denote that these chemicals are not included in the HPV Challenge Program.
The description of this indicator reads:
A few Class 2 substances and pigments, which may be polymers or inorganics, may remain on the HPV Challenge Program Chemical List because the name and/or definition provided by the original submitter to the TSCA Inventory lacked conclusive information on which to determine whether the chemical was a polymer or inorganic substance. In the absence of additional definitive information, those substances were left on the HPV Challenge Program Chemical List.
Although the HPV Challenge Program Chemical List was developed using Inventory Update Rule submissions, the removal of chemicals from the scope of the HPV Challenge Program does not necessarily mean that they are excluded from current or future IUR reporting. All questions concerning whether a chemical is subject to IUR reporting should be submitted to the Agency as described in the IUR Instruction Manual (http://www.epa.gov/opptintr/iur98).
| 85416 | 88448 | 88608 | 89725 |
| 91769 | 93685 | 98920 | 99047 |
| 101837 | 118796 | 119471 | 126330 |
| 141979 | 611198 | 16219753 | 34590948 |
Indicator Values
Sponsorship Status ValuesThe Sponsorship Status Column will be periodically updated as commitments are received by the Agency. In addition, a link to the actual letters received by sponsor will be added at a later date.
Changes made on October 27, 1999:
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to add a new column identifying the companies or consortia that have submitted full or provisional commitments to EPA to sponsor chemicals under the HPV Challenge Program. The lists reflect responses received through the close of business on October 15, 1999. The Agency has also updated the lists to reflect changes to chemical sponsorship under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.
If you have any questions concerning this list, please submit them using the comment button located at the bottom of this page.
Sponsor Commitment Status Column
Companies or consortia that have submitted full or provisional commitments to EPA to sponsor chemicals under the HPV Challenge Program are identified in a new column entitled Sponsor Commitment Status. In addition to the company or consortium name, an "F" or "P" is shown in brackets, indicting whether the commitment is full or provisional. Consortia member companies are not listed. Please consult the HPV Challenge Summary Report to learn which companies or organizations are members of a particular consortium (www.epa.gov/chemrtk/sumresp.htm). The start year for the chemical is also included in this column.
In this column, "F" and "P" refer specifically to the commitment of a company or consortium to sponsor a particular chemical. The "F" or "P" shows whether the company or consortium has provided all or only part of the required elements for a commitment to the Program. This differs from the "F" and "P" found in the Chemical Sponsorship Status column.
Chemical Sponsorship Status Column
The "F" and "P" found in the Chemical Sponsorship column refer to the status of a chemical in the HPV Challenge Program. A chemical is fully sponsored if the Agency has received at least one full commitment from a company or consortium. A chemical is provisionally sponsored if the Agency has received at least one provisional commitment, but no full commitments, from a company or consortium.
A description of what constitutes full and provisional commitments and fully and provisionally sponsored chemicals can be found in the section on "How to Use the Lists."
Both the Chemical Sponsorship Status and the Sponsor Commitment Status columns will be updated weekly as commitments are received by the Agency. In addition, a link to the actual letters submitted or received by sponsors will be added at a later date. The Sponsor Commitment Status column is not yet searchable, and data from that column will not appear in searches performed using the other indicators available on the list. The Agency is currently modifying the search function to allow searches using data in this column, and when that search capability becomes available, the Agency will provide notification on the "What's New" page.
The Agency recognizes that some chemicals are sponsored by more than one company or consortium. In these cases, the Agency suggests that the companies or consortia coordinate sponsorship of the particular chemical to avoid duplication of effort and ensure costs are minimized. When multiple companies or consortia submit commitments covering the same chemical, the Agency contacts all of the sponsors to alert them to the duplication and to encourage coordination of effort.
SIDS Chemicals
The Agency has updated the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to add an indicator of "2" to thirteen chemicals. The "2" indicator denotes chemicals that are otherwise being handled under the OECD HPV SIDS Program. Eight of these 13 chemicals were selected in the latest phase of the OECD HPV SIDS chemical selection process. The chemicals were nominated by sponsor countries at the SIDS Initial Assessment Meeting held in Paris, France June 29-30, July 1, 1999. The remaining five chemicals (74-87-3, 111-41-1, 135-19-3, 4461-52-3, and 20324-32-7) are also in the SIDS Program and were nominated at other times. Twelve of the 13 chemicals are on the HPV Challenge Program Chemical List. The remaining chemical is on the 1994 List of HPV Additions. The thirteen chemicals, listed by CAS number, are:
| 74-87-3 | 111-41-1 | 839-90-7 | 25321-09-9 |
| 80-09-1 | 123-11-5 | 1330-20-7 | |
| 94-36-0 | 135-19-3 | 4461-52-3 | |
| 98-51-1 (1994 list) |
793-24-8 | 20324-32-7 |
Additionally, the indicator "2" was removed from two chemicals (25640-78-2 and 26896-20-8), as these chemicals are no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program.
The HPV Challenge Program Chemical List and the 1994 List of HPV Additions are provided below for downloading in two forms, DBF and Portable Data Format (PDF). While the content of the lists in DBF and PDF format are the same, the DBF versions include more records than the PDF versions. With the PDF versions, the CAS number is listed only once for all companies and consortia that are sponsoring that chemical. With the DBF versions, the CAS number is repeated for each sponsor. Repeating the information allows users to sort the file by something other than CAS number. A key to the various values used in the lists can be found on the "How to Use the Lists" page.
November 5, 1999
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on October 29, 1999.
November 10, 1999
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 5, 1999. Additionally, an indicator of "2" was added to CAS No. 77-92-9 indicating that this chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program. An indicator of "3" was added to CAS No. 11097-59-9 indicating that this chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.
November 17, 1999
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 12, 1999.
November 30, 1999
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 26, 1999. If you have any questions concerning these lists, please submit them using the comment button located at the bottom of this page.
March 7, 2000
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on March 3, 2000. This update captures all commitments received by the close of the voluntary sign-up period on December 1, 1999.
An indicator of "2" was added to CAS Nos. 95-50-1, 106-42-3, 624-41-9, and 25376-45-8, indicating that these chemicals are otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.
Three new codes were added to the list during this update, two numerical ones in the "Indicator" column and one letter code in both the "Chemical Sponsorship Status" and the "Sponsor Commitment Status" columns. These new codes are:
Indicator Column Values:June 16, 2000
December 15, 2000
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on December 1, 2000. This update captures all commitments received by close of the voluntary sign-up period on December 1, 1999. Letters received since December 1, 1999 generally reflect clarifications to previously submitted commitments.
The International Council of Chemical Associations (ICCA) HPV commitments have also been updated at this time
Indicator Column Values:
An
indicator of "1" was added to the CAS Numbers below indicating that these
chemicals are not considered candidates for testing under the HPV Challenge
Program, based on preliminary EPA review indicating that testing using the
SIDS base set would not further our understanding of the chemical's properties.
These chemicals may be sponsored, however.Ind = 1
142472 65996636 65996647
An
indicator of "2" was added to the CAS Numbers below indicating that these
chemicals are otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS)
Program.Ind = 2
An
indicator of "5" was added to the CAS Numbers below indicating that these
chemicals meet the criteria for being "No Longer HPV" and are no longer
subject to the HPV Challenge Program. These chemicals may be sponsored,
however.Ind = 5
| 54217 | 85698 | 89087 | 94746 | 132274 | 139026 |
| 554121 | 616217 | 13927770 | 28984896 | 68476482 | 68477225 |
| 68609643 |
Chemical Sponsorship Status Column Values:
All confirmed Company and Consortium ICCA commitments are identified in a letter to EPA's Administrator from ICCA dated August 4, 2000. This letter supercedes the earlier ICCA letter dated February 25, 2000.
Company or consortium has clearly indicated to and has had confirmed by ICCA their sponsorship of a chemical(s) in the HPV Initiative of the International Council of Chemical Associations.
Companies can meet the requirements of the HPV Challenge Program either directly through the Challenge Program or indirectly through the OECD HPV SIDS Program and/or the ICCA HPV Initiative. U.S. companies deciding to sponsor chemicals under the HPV Challenge Program can also identify those chemicals as U.S. contributions to the OECD HPV SIDS Program and/or the ICCA HPV Initiative. Such chemicals may have both an "I" (confirmed ICCA sponsorship) and an "F" (Full sponsorship or fully sponsored HPV Challenge Program Commitment) in the Sponsor Commitment Status field.
It is noted that a chemical with confirmed sponsorship under the ICCA HPV Initiative may not be listed with a "4" in the indicator column. All data elements necessary for Full Commitment status under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) must also be provided to the Agency in order for the chemical to be designated as an ICCA sponsored chemical under the HPV Challenge Program (and thus receive a "4" in the indicator column.
October 12, 2001
The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on July 13, 2001. This update generally reflects clarifications or changes to previously submitted commitments.
These updated lists also reflect changes to the following Indicator Column Values:
Indicator = 1
An
indicator of "1" was added to the CAS Numbers below indicating that these
chemicals are not considered candidates for testing under the HPV Challenge
Program, based on preliminary EPA review indicating that testing using the
SIDS base set would not further our understanding of the chemical's properties.
These chemicals may be sponsored, however.Indicator = 2
An
indicator of "2" was added to the CAS Numbers below indicating that these
chemicals are otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS)
Program.HPV Challenge Program Chemical List:
| 50000 | 105602 | 124403 | 7659861 | 64742489 |
| 56815 | 105646 | 128370 | 8032324 | 64742490 |
| 58082 | 106310 | 134203 | 8052413 | 64742810 |
| 65850 | 107415 | 137326 | 13674878 | 64742821 |
| 68111 | 107926 | 139333 | 13952846 | 64742887 |
| 68122 | 107960 | 139899 | 15708415 | 64742898 |
| 71410 | 108112 | 140012 | 16111629 | 64742945 |
| 74895 | 108189 | 142825 | 16470249 | 64742956 |
| 75014 | 108214 | 142847 | 16485475 | 64771728 |
| 75047 | 108394 | 142905 | 18328900 | 66455172 |
| 75310 | 108678 | 287923 | 18719034 | 67762258 |
| 75387 | 108918 | 528449 | 20824560 | 67762270 |
| 75503 | 109524 | 532321 | 21265509 | 67762305 |
| 75649 | 109604 | 538932 | 22473785 | 67762418 |
| 75683 | 109739 | 540841 | 25103097 | 67859512 |
| 77474 | 109831 | 544763 | 25155253 | 68333802 |
| 78637 | 109897 | 552307 | 25264931 | 68390567 |
| 78784 | 110054 | 582252 | 25339564 | 68410968 |
| 78922 | 110190 | 598561 | 25377837 | 68410979 |
| 78966 | 110543 | 614459 | 25550145 | 68476506 |
| 79094 | 110623 | 629505 | 25584832 | 68477316 |
| 79312 | 110918 | 629629 | 26523784 | 68516187 |
| 79345 | 111273 | 629732 | 26748414 | 68527059 |
| 79947 | 111659 | 629969 | 27215958 | 68551166 |
| 80159 | 111842 | 661198 | 29964849 | 68551177 |
| 80433 | 111864 | 818611 | 30618849 | 68551199 |
| 88733 | 111875 | 822060 | 32360057 | 68551202 |
| 88744 | 111922 | 927071 | 36653824 | 68603156 |
| 90722 | 112301 | 1222055 | 38051104 | 68603178 |
| 95658 | 112403 | 1321944 | 45294186 | 68911615 |
| 96059 | 112425 | 1338234 | 61788452 | 70024929 |
| 96184 | 112709 | 1704627 | 61788463 | 70693060 |
| 97723 | 112721 | 1761713 | 63393828 | 70955112 |
| 97858 | 112889 | 2050922 | 64741635 | 75782864 |
| 98942 | 112903 | 2495274 | 64741657 | 75782875 |
| 100378 | 116530 | 2549533 | 64741737 | 90622461 |
| 100516 | 121448 | 2935902 | 64741840 | 93924073 |
| 102067 | 121915 | 3006824 | 64741851 | 129813678 |
| 102829 | 123057 | 3033623 | 64741919 | |
| 103093 | 123626 | 5332730 | 64742069 | |
| 104756 | 123966 | 5421465 | 64742467 | |
| 105599 | 124301 | 7534943 | 64742478 |
1994 List of HPV Additions:
| 58559 107835 1939362 3425614 | 19910657 |
| 107711 1717006 2495252 6140745 | 25378227 |
Additionally, the indicator "2" was removed from the following chemical, as this chemical is no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program:
Indicator = 4
No
new Indicator "4"s have been added to the list. All confirmed Company and
Consortium International Council of Chemical Associations (ICCA) commitments
are identified in a letter to EPA's Administrator from ICCA dated August
4, 2000. This letter supercedes the earlier ICCA letter dated February 25,
2000.Indicator = 5
An
indicator of "5" was added to the CAS Numbers below indicating that these
chemicals meet the criteria for being "No Longer HPV" and are no longer
subject to the HPV Challenge Program. These chemicals may be sponsored,
however.| 62544107562118296141526141980 | 693210 |
| 149768327380694356609642343413393936 | 13889924 |
| 1756464618169578250374503213117236876138 | 39464705 |
| 5283631455701058617903506830867868443856 | 73467773 |
The following Values were added to the Sponsor Commitment Status Column:
V = Viable Commitment. Same as Full Commitment but the commitment to sponsor the particular chemical was received after the December 26, 2000 proposed test rule was published (65 FR 81658). In addition to meeting the standard requirements of the HPV Challenge Program, sponsors must also provide full copies of studies for viable chemicals.
Q = Provisional Viable Commitment. Same as Provisional Commitment (all the required commitment information was not provided.) but the commitment to sponsor a particular chemical was received after the December 26, 2000 proposed test rule was published (65 FR 81658). Provisional viable commitments will be upgraded to Viable status (see above) upon receipt and processing of required commitment information.
V = Viable-Sponsored Chemical. The Agency has received at least one viable commitment from a company or consortium to sponsor the particular chemical.
Q = Provisional Viable-Sponsored Chemical. Company/Consortia has provided most, but not all, of the Viable Commitment information. The Agency has received at least one provisional viable commitment, but not viable commitments, from a company or consortium to sponsor the particular chemical.
A = Test Rule Chemical. Chemicals listed in the proposed "Testing of Certain High Production Volume Chemicals; Data Collection and Development on High Production Volume (HPV) Chemicals" rule (65 FR 81658). These chemicals may be sponsored prior to publishing a final rule. Note that sponsorship after the December 26, 2000 date (a viable commitment) requires that, in addition to meeting the standard requirements of the HPV Challenge Program, sponsors also provide full copies of studies.
C = Voluntary Children's Chemical Evaluation Program Chemical. Chemicals listed in the Voluntary Children's Chemical Evaluation Program notice (64 FR 81699). These chemicals may be sponsored. Note that sponsorship after the December 26, 2000 date (a viable commitment) requires that, in addition to meeting the standard requirements of the HPV Challenge Program, sponsors also provide full copies of studies.
March 13, 2002
In some cases, companies or consortia have sponsored chemicals that are not on either the HPV Challenge Program Chemical List or the 1994 List of HPV Additions. A list of these chemicals, called "Additional Chemicals Sponsored Under the HPV Challenge Program" is being added with this update. The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on January 18, 2002. This update generally reflects clarifications or changes to previously submitted commitments.
These updated lists also reflect changes to the following Indicator Column Values:
Indicator = 1
No
new indicators of "1" were added to the list. A "1" indicates that the chemical
is not considered a candidate for testing under the HPV Challenge Program,
based on preliminary EPA review indicating that testing using the SIDS base
set would not further our understanding of the chemical's properties. A
chemical with an indicator of "1" may be sponsored, however.Indicator = 2
An
indicator of "2" was added to the CAS Numbers below indicating that these
chemicals are otherwise being handled under the Organization for Economic
Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS)
Program.|
CAS Number CAS Number CAS Number CAS Number |
CAS Number |
|
75763 75945 78104 80104 |
98135 |
|
107186 107460 108463 108985 |
115219 |
|
124709 131179 527071 540976 |
541026 |
|
541059 675627 872504 919302 |
919313 |
|
999973 1066359 1067534 1185553 |
1310583 |
|
1310732 1313139 1322981 1760243 |
2487903 |
|
2530838 2530872 2550063 4253343 |
4518983 |
|
7351613 7447407 7647010 7778543 |
7782505 |
|
10025782 10026047 10043524 11099062 |
12125029 |
|
13528886 17689779 22984549 27636755 |
85117506 |
Additionally, the indicator "2" was removed from the following chemical2, as these chemicals are no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program:
Indicator = 4
Based
on the January 31, 2002 letter from ICCA, new Indicator "4"s have been added
to the list. All confirmed Company and Consortium International Council
of Chemical Associations (ICCA) commitments are identified in letters to
EPA's Administrator from ICCA dated August 4, 2000 and January 31, 2002.
These letters supercede the earlier ICCA letter dated February 25, 2000.Indicator = 5
No
new indicator "5"s were added to the lists. A "5" indicates that the chemical
meets the criteria for being "No Longer HPV" and is no longer subject to
the HPV Challenge Program. A chemical with an indicator of "5" may be sponsored,
however.May 22, 2002
The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on March, 15, 2002. This update generally reflects clarifications or changes to previously submitted commitments.
August 8, 2002
The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on July 12, 2002. This update generally reflects clarifications or changes to previously submitted commitments.
These updated lists also reflect changes to the following Indicator Column Values:
Indicator = 1
No new indicators of "1" were added to the list. A "1" indicates that the chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. A chemical with an indicator of "1" may be sponsored, however.Indicator = 2
No
new incator "2" were added to the list. A "2" indicates
that these chemicals are otherwise being handled under the Organization
for Economic Cooperation and Development (OECD) HPV Screening Information
Data Set (SIDS) Program. Indicator = 4
No new indicator
"4" was added to the list. All confirmed International Council
of Chemical Associations (ICCA) commitments are identified in documents
to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002
and April 12, 2002. These letters supercede the earlier ICCA letter dated
February 25, 2000.
Indicator = 2,4
An Indicator "2,4" was added to the CAS numbers below. A "2" indicates that
these chemicals are otherwise being handled under the Organizational for
Economic Cooperation and Development (OECD) HPV Screening Information Data
Set (SIDS) Program and a indicator "4" indicates that these chemicals are
confirmed International Council of Chemical Associations (ICCA) commitments
identified in documents to EPA's Administrator from ICCA dated August 4,
2000, January 31, 2002 and April 12, 2002. These letters supercede the earlier
ICCA letter dated February 25, 2000.
| Chemicals receiving new Ind=2, 4 flags |
| 75127 | 3323533 |
| 78591 | 4454051 |
| 87569 | 6104309 |
| 100005 | 288324 |
| 106445 | 1312761 |
| 115071 | 1490046 |
| 115866 | 6834920 |
| 120809 | 7775146 |
| 603350 | 7791255 |
| 947046 | 10213793 |
| 1319773 | 13517243 |
| 1328536 | 85422920 |
| 2855132 | 86089170 |
No new indicator
"5"s were added to the lists. A "5" indicates that the
chemical meets the criteria for being "No Longer HPV" and is no
longer subject to the HPV Challenge Program. A chemical with an indicator
of "5" may be sponsored, however.View the 1990 HPV Challenge Program Chemical List, the 1994 IUR List of HPV Additions or the Additional Chemicals Sponsored Under the HPV Challenge Program.
November 21, 2002
A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.
No new indicators of "1" were added to the list.
Indicator = 2 (SIDS)
A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.
An indicator of "2" was added to the CAS numbers below indicating that these chemicals are otherwise being handled under the OCED SIDS program.
| 60242 | 67481 | 67561 | 75978 | 77587 |
| 78046 | 89781 | 97905 | 100709 | 108894 |
| 109091 | 109160 | 110894 | 111488 | 112276 |
| 112594 | 112607 | 144558 | 496720 | 497198 |
| 870086 | 994058 | 1118463 | 2235430 | 2687254 |
| 2809214 | 3091256 | 4792158 | 5995426 | 8013078 |
| 8016113 | 10126688 | 13547701 | 15356602 | 15827608 |
| 20592852 | 22042962 | 22591215 | 26864379 | 26998970 |
| 27193868 | 29329713 | 42272708 | 55680030 | 61789013 |
| 67845947 | 67845958 | 67953768 | 68186903 | 68391117 |
| 68609927 | 74499357 | 88917220 | 98246878 | 122384854 |
| 122384876 | 201687572 |
An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS Program.
75070 75150 75218 110270 72275866
Indicator = 3 (Polymer or Inorganic)
A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.
No new indicators of "3" were added to the list.
Indicator = 4 (ICCA)
Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."
Based on the August 26, 2002 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.
Indicator = 5 (No Longer HPV)
A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.
No new indicators of "5" were added to the list.
December 18, 2002
A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.
No new indicators of "1" were added to the list.
Indicator = 2 (SIDS)
A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.
An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.
| 110305 | 210555945 |
An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.
27193868
Indicator = 3 (Polymer or Inorganic)
A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.
No new indicators of "3" were added to the list.
Indicator = 4 (ICCA)
Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4." All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.
No new indicators of "4" were added to the list. Indicator = 5 (No Longer HPV)
A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.
No new indicators of "5" were added to the list.
March 6, 2003
A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.
No new indicators of "1" were added to the list.
Indicator = 2 (SIDS)
A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.
An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.
| 64186 | 74931 | 75081 | 75661 | 79210 |
| 79221 | 79389 | 95476 | 106423 | 106752 |
| 107039 | 107313 | 108236 | 108383 | 109795 |
| 111886 | 112550 | 141537 | 142961 | 280579 |
| 501531 | 541413 | 544172 | 760678 | 1344009 |
| 2837890 | 3268493 | 3282302 | 4300974 | 5188078 |
| 6422862 | 24468131 | 25103586 | 25360105 | 40292828 |
| 68153300 | 68953582 |
An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.
1319773
Indicator = 3 (Polymer or Inorganic)
A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.
No new indicators of "3" were added to the list.
Indicator = 4 (ICCA)
Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4." All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, and August 26, 2002.
No new indicators of "4" were added to the list.
Indicator = 5 (No Longer HPV)
A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.
No new indicators of "5" were added to the list.
June 4, 2003
In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.
A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.
No new indicators of "1" were added to the list.
Indicator = 2 (SIDS)
A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.
An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.
| 64-17-5 | 78-87-5 |
Indicator = 3 (Polymer or Inorganic)
A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.
No new indicators of "3" were added to the list.
Indicator = 4 (ICCA)
Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."
Based on the March 28, 2003 from ICCA, new indicators of "4" have been added to the list. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, and March 28, 2003.
Indicator = 5 (No Longer HPV)
A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.
An indicator of "5" was added to the CAS numbers below.
| 825-90-1 | 1572-52-7 |
| 61791-47-7 | 27288-44-4 |
September 3, 2003
In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.
A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.
No new indicators of "1" were added to the list.
Indicator = 2 (SIDS)
A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.
An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.
| 75-00-3 | 31570-04-4 |