References and Notes
1. DeVito M, Crofton K, McMaster S. Screening Methods
for Chemicals That Alter Thyroid Hormone Action, Function and Homestasis. EPA
600-R-98-057. Durham, NC:U.S. Environmental Protection Agency, 1997.
2. Fisher DA. Fetal thyroid function: diagnosis and management
of fetal thyroid disorders. Clin Obstet Gynecol 40(1):16-31 (1997).
3. Shepard TH. Onset of function in the human fetal thyroid:
biochemical and radioautographic studies from organ culture. J Clin Endocrinol
Metab 27(7):945-958 (1967).
4. Thorpe-Beeston JG, Nicolaides KH, McGregor AM. Fetal
thyroid function. Thyroid 2:207-217 (1992).
5. Köhrle J. Thyroid hormone metabolism and action
in the brain and pituitary. Acta Med Austriaca 27(1):1-7 (2000).
6. Glinoer D, Delange F. The potential repercussions of
maternal, fetal, and neonatal hypothyroxinemia on the progeny. Thyroid 10(10):871-887
(2000).
7. Contempré B, Jauniaux E, Calvo R, Jurkovic D,
Campbell S, Morreale de Escobar G. Detection of thyroid hormones in human embryonic
cavities during the first trimester of pregnancy. J Clin Endocrinol Metab 77(6):1719-1722
(1993).
8. Kaplan MM. The maternal thyroid and parathyroid glands.
In: Maternal and Fetal Endocrinology, 2nd ed (Tulchinsky D, Little AB, eds).
Philadelphia:W.B. Saunders, 1994;131-149.
9. Vulsma T, Gons MH, De Vijlder JJM. Maternal-fetal transfer
of thyroxine in congenital hypothyroidism due to total organification defect
or thyroid agenesis. N Eng J Med 321(1):13-16 (1989).
10. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight
GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, et al. Maternal
thyroid deficiency during pregnancy and subsequent neuropsychological development
of the child. N Engl J Med 341(8):549-555 (1999).
11. Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son
MM, de Vijder JJ, Vulsma T, Wiersinga WM, Drexhage HA, Vader HL. Low maternal
free thyroxine concentrations during early pregnancy are associated with impaired
psychomotor development in infancy. Clin Endocrinol 50:149-155 (1999).
12. Klein RZ, Sargent JD, Larsen PR, Waisbren SE, Haddow
JE, Mitchell ML. Relation of severity of maternal hypothyroidism to cognitive
development of offspring. J Med Screen 8:18-20 (2001).
13. Leneman M, Buchanan L, Rovet J. Where and what
visuospatial processing in adolescents with congenital hypothyroidism. J Int
Neuropsychol 7:556-562 (2001).
14. Bernal J, Pekonen F. Ontogenesis of the nuclear 3,5,3'-triiodothyronine
receptor in the human fetal brain. Endocrinology 114(2):677-679 (1984).
15. Ferreiro B, Bernal J, Goodyer CG, Branchard CL. Estimation
of nuclear thyroid hormone receptor saturation in human fetal brain and lung
during early gestation. J Clin Endocrinol Metab 67(4):853-856 (1988).
16. Oppenheimer JH, Swartz HL. Stereo specific transport
of triiodothyronine from plasma to cytosol and from cytosol to nucleus in rat
liver, kidney, brain, and heart. J Clin Invest 75:147-154 (1985).
17. Fisher DA, Klein AH. Thyroid development and disorders
of thyroid function in the newborn. N Engl J Med 304(12):702-712 (1981).
18. Lazar MA. Thyroid hormone receptors: multiple forms,
multiple possibilities. Endocr Rev 14(2):184-193 (1993).
19. Iskaros J, Pickard M, Evans I, Sinha A, Hardiman P,
Ekins R. Thyroid hormone receptor gene expression in first trimester human fetal
brain. J Clin Endocrinol Metab 85(7):2620-2623 (2000).
20. Kilby MD, Gittoes N, McCabe C, Verhaeg J, Franklyn
JA. Expression of thyroid receptor isoforms in the human fetal central nervous
system and the effects of intrauterine growth restriction. Clin Endocrinol 53:469-477
(2000).
21. Zhang SS, Carrillo AJ, Darling DS. Expression of multiple
thyroid hormone receptor mRNAs in human oocytes, cumulus cells, and granulosa
cells. Mol Hum Reprod 3(7):555-562 (1997).
22. Fisher DA, Dussault JH, Sack J, Chopra IJ. Ontogenesis
of hypothalamic-pituitary-thyroid function and metabolism in man, sheep, and
rat. Recent Prog Horm Res 33:59-116 (1976).
23. Roti E. Regulation of thyroid-stimulating hormone
(TSH) secretion in the fetus and neonate. J Endocrinol Invest 11:145-158
(1988).
24. Thliveris JA, Currie RW. Observations on the hypothalamo-hypophyseal
portal vasculature in the developing human fetus. Am J Anat 157(4):441-444
(1980).
25. Winters AJ, Eskay RL, Porter JC. Concentration and
distribution of TRH and LRH in the human fetal brain. J Clin Endocrinol Metab
39(5):960-963 (1974).
26. Aubert ML, Grumbach MM, Kaplan SL. The ontogenesis
of human fetal hormones. IV: Somatostatin, luteinizing hormone releasing factor,
and thyrotropin releasing factor in hypothalamus and cerebral cortex of human
fetuses 10-22 weeks of age. J Clin Endocrinol Metab 44(6):1130-1141 (1977).
27. Kaufman MH, Bard JBL. Index 5.2: Table of mouse and
rat development. In: The Anatomical Basis of Mouse Development (Kaufman MH,
Bard JBL, eds). San Diego, CA:Academic Press, 1999;220-223.
28. Morreale de Escobar G, Pastor R, Obregon MJ, Escobar
del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone
content of rat embryonic tissues, before and after onset of fetal thyroid function.
Endocrinology 117(5):1890-1900 (1985).
29. Woods RJ, Sinha AK, Ekins RP. Uptake and metabolism
of thyroid hormones by the rat foetus in early pregnancy. Clin Sci (London)
67(3):359-363 (1984).
30. Versloot PM, Schröder-van der Elst JP, van der
Heide D, Boogerd L. Effects of marginal iodine deficiency on thyroid hormone
production, distribution and transport in nonpregnant and near-term pregnant
rats. Eur J Endocrinol 138:713-718 (1998).
31. Calvo R, Obregon MJ, Ruiz de Oña C, Escobar
del Rey F, Morreale de Escobar G. Congenital hypothyroidism, as studied in rats:
crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the
protection of the fetal brain. J Clin Invest 86:889-899 (1990).
32. Obregon MJ, Mallol J, Pastor R, Morreale de Escobar
G, Escobar del Rey F. l-Thyroxine and 3,5,3'-triiodo-l-thyronine in rat embryos
before onset of fetal thyroid function. Endocrinology 114(1):305-307 (1984).
33. Dussault JH, Labrie F. Development of the hypothalamic-pituitary-thyroid
axis in the neonatal rat. Endocrinology 97(5):1321-1324 (1975).
34. Perez-Castillo A, Bernal J, Ferreiro B, Pans T. The
early ontogenesis of thyroid hormone receptor in the rat fetus. Endocrinology
117(6):2457-2461 (1985).
35. Bradley DJ, Towle HC, Young WS. Alpha and beta thyroid
hormone receptor (TR) gene expression during auditory neurogenesis: evidence
for TR isoform-specific transcriptional regulation in vivo. Proc Natl Acad Sci
U S A 91(2):439-443 (1994).
36. Falcone M, Miyamoto T, Fierro-Renoy F, Macchia E,
DeGroot LJ. Evaluation of the ontogeny of thyroid hormone receptor isotypes
in rat brain and liver using an immunohistochemical technique. Eur J Endocrinol
130:97-106 (1994).
37. Oppenheimer JH, Schwartz HL. Molecular basis of thyroid
hormone-dependent brain development. Endocr Rev 18(4):462-475 (1997).
38. Ferreiro B, Pastor R, Bernal, J. T3 receptor occupancy
and T3 levels in plasma and cytosol during rat brain development. Acta Endocrinol
(Copenh) 123(1):95-99 (1990).
39. Bradley DJ, Towle HC, Young WS III. Spatial and temporal
expression of - and ß-thyroid
hormone receptor mRNAs, including ß2-subtype, in the developing
mammalian nervous system. J Neurosci 12(6):2288-2302 (1992).
40. Strait KA, Schwartz HL, Seybold VS, Ling NC, Oppenheimer
JH. Immunofluorescence localization of thyroid hormone receptor protein ß1
and variant 2 in selected
tissues: cerebellar Purkinje cells as a model for ß1 receptor-mediated
developmental effects of thyroid hormone in brain. Proc Natl Acad Sci U S A
88(9):3887-3891 (1991).
41. Leonard JL, Farwell AP, Yen PM, Chin WW, Stula M.
Differential expression of thyroid hormone receptor isoforms in neurons and
astroglial cells. Endocrinology 135(2):548-555 (1994).
42. Forrest D, Vennstrom B. Functions of thyroid hormone
receptors in mice. Thyroid 10(1):41-52 (2000).
43. Rodríguez-García M, Jolín T,
Santos A, Pérez-Castillo A. Effect of perinatal hypothyroidism on the
developmental regulation of rat pituitary growth hormone and thyrotropin genes.
Endocrinology 136(10):4339-4350 (1995).
44. Oliver C, Eskay, RL, Porter JC. Developmental changes
in brain TRH and in plasma and pituitary TSH and prolactin levels in the rat.
Biol Neonate 37(3-4):145-152 (1980).
45. Burgunder JM, Taylor T. Ontogeny of thyrotropin-releasing
hormone gene expression in the rat diencephalon. Neuroendocrinology 49(6):631-640
(1989).
46. Shambaugh GE, Kubek M, Wilber JF. Characterization
of rat placental TRH-like material and the ontogeny of placental and fetal brain
TRH. Placenta 4(4):329-337 (1983).
47. Strbak V, Greer MA. Acute effects of hypothalamic
ablation on plasma thyrotropin and prolactin concentrations in the suckling
rat: evidence that early postnatal pituitary-thyroid regulation is independent
of hypothalamic control. Endocrinology 105(2):488-492 (1979).
48. Rice D, Barone S. Critical periods of vulnerability
for the developing nervous system: evidence from humans and animal models. Environ
Health Perspect 108(suppl 3):511-533 (2000).
49. Bayer SA, Altman J, Russo RJ, Zhang X. Timetables
of neurogenesis in the human brain based on experimentally determined patterns
in the rat. Neurotoxicology 14(1):83-144 (1993).
50. Gould E, Tanapat P, Hastings NB, Shors TJ. Neurogenesis
in adulthood: a possible role in learning. Trends Cogn Sci 3(5):186-192
(1999).
51. Kornack DR, Rakic P. The generation, migration, and
differentiation of olfactory neurons in the adult primate brain. Proc Natl Acad
Sci U S A 98(8):4752-4757 (2001).
52. Herschkowitz N, Kagan J, Zilles K. Neurobiological
bases of behavioral development in the first year. Neuropediatrics 28:296-306
(1997).
53. Lauder JM, Bloom FE. Ontogeny of monoamine neurons
in the locus coeruleus, raphe nuclei and substantia nigra of the rat. II: Synaptogenesis.
J Comp Neurol 163(3):251-264 (1975).
54. Swann JW, Smith KL, Brady RJ. Neural networks and
synaptic transmission in immature hippocampus. Adv Exp Med Biol 268:161-171
(1990).
55. Sutor B, Luhmann HJ. Development of excitatory and
inhibitory postsynaptic potentials in the rat neocortex. Perspect Dev Neurobiol
2(43):409-419 (1995).
56. Knipper M, Bandtlow C, Gestwa L, Köpschall I,
Rohbock K, Wiechers B, Zenner H-P, Zimmermann U. Thyroid hormone affects Schwann
cell and oligodendrocyte gene expression at the glial transition zone of the
VIIIth nerve prior to cochlea function. Development 125:3709-3718
(1998).
57. Ibarrola N, Rodríguez-Peña A. Hypothyroidism
coordinately and transiently affects myelin protein gene expression in most
rat brain regions during postnatal development. Brain Res 752:285-293 (1997).
58. Dussault JH, Ruel J. Thyroid hormones and brain development.
Ann Rev Physiol 49:321-334 (1987).
59. Porterfield SP, Hendrich CE. The role of thyroid hormones
in prenatal and neonatal neurological development--current perspectives. Endocr
Rev 14(1):94-106 (1993).
60. Bernal J, Nunez J. Thyroid hormones and brain development.
Eur J Endocrinol 133(4):390-398 (1995).
61. Koibuchi N, Chin WW. Thyroid hormone action and brain
development. Trend Endocrinol Metab 11(4):123-128 (2000).
62. Thompson CC, Potter GB. Thyroid hormone action in
neural development. Cereb Cortex 10:939-945 (2000).
63. Nicholson JL, Altman J. The effects of early hypo-
and hyperthyroidism on the development of rat cerebellar cortex. I: Cell proliferation
and differentiation. Brain Res 44:13-23 (1972).
64. Xiao Q, Nikodem VM. Apoptosis in the developing cerebellum
of the thyroid hormone deficient rat. Front Biosci 3:a52-a57 (1998).
65. Neveu I, Arenas E. Neurotrophins promote the survival
and development of neurons in the cerebellum of hypothyroid rats in vivo. J
Cell Biol 133(3):631-646 (1996).
66. Muller Y, Rocchi E, Lazaro JB, Clos J. Thyroid hormone
promotes BCL-2 expression and prevents apoptosis of early differentiating cerebellar
granule neurons. Int J Dev Neurosci 13(8):871-885 (1995).
67. Balazs R, Kovacs S, Teichgraber P, Cocks WA, Eayrs
JT. Biochemical effects of thyroid deficiency on the developing brain. J Neurochem
15(11):1335-1349 (1968).
68. Alvarez-Dolado M, Ruiz M, Del Rio JA, Alcántara
S, Burgaya F, Sheldon M, Nakajima K, Bernal J, Howell BW, Curran T, et al. Thyroid
hormone regulates reelin and dab1 expression during brain development.
J Neurosci 19(16):6979-6693 (1999).
69. Farwell AP, Dubord-Tomasetti SA. Thyroid hormone regulates
the expression of laminin in the developing rat cerebellum. Endocrinology 140(9):4221-4227
(1999).
70. Farwell AP, Dubord-Tomasetti SA. Thyroid hormone regulates
the extracellular organization of laminin on astrocytes. Endocrinology 140(11):5014-5021
(1999).
71. Eayrs JT. The cerebral cortex of normal and hypothyroid
rats. Acta Anat 25:160-183 (1955).
72. Nicholson JL, Altman J. The effects of early hypo-
and hyperthyroidism on the development of the rat cerebellar cortex. II: Synaptogenesis
in the molecular layer. Brain Res 44(1):25-36 (1972).
73. Ruiz-Marcos A, Sanchez-Toscano F, Escobar del Rey
F, Morreale de Escobar G. Severe hypothyroidism and the maturation of the rat
cerebral cortex. Brain Res 162(2):315-329 (1979).
74. Gravel C, Hawkes R. Maturation of the corpus callosum
of the rat. I: Influence of thyroid hormones on the topography of callosal projections.
J Comp Neurol 291:128-146 (1990).
75. Rami A, Rabie A. Delayed synaptogenesis in the dentate
gyrus of the thyroid-deficient developing rat. Dev Neurosci 12:398-405
(1990).
76. Thompson CC. Thyroid hormone-responsive genes in developing
cerebellum include a novel synaptotagmin and a hairless homolog. J Neurosci
16(24):7832-7840 (1996).
77. Rodríguez-Peña A. Oligodendrocyte development
and thyroid hormone. J Neurobiol 40(4):497-512 (1999).
78. Rakic P. Guidance of neurons migrating to the fetal
monkey neocortex. Brain Res 33(2):471-476 (1971).
79. Sidman RL, Rakic P. Neuronal migration with special
reference to developing human brain: a review. Brain Res 62 (1):1-35 (1973).
80. Mission J-P, Takahashi T, Caviness VS Jr. Ontogeny
of radial and other astroglial cells in murine cerebral cortex. Glia 4:138-148
(1991).
81. Gressens P, Gofflot F, van Maele-Fabry G, Mission
J-P, Gadisseux J-F, Evrard P, Picard JJ. Early neurogenesis and teratogenesis
in whole mouse embryo cultures. Histochemical, immunocytological and ultrastructural
study of the premigratory neuronal-glial units in normal mouse embryo and in
mouse embryos influenced by cocaine and retinoic acid. J Neuropathol Exp Neurol
51:206-219 (1992).
82. Alliot F, Godin I, Pessac B. Microglia derive from
progenitors, originating from the yolk sac, and which proliferates in the brain.
Brain Res Dev Brain Res 117(2):145-152 (1999).
83. Schwab JM, Schluesener HJ, Seid K, Meyermann R. IL-16
is differentially expressed in the developing human fetal brain by microglial
cells in zones of neuropoesis. Int J Dev Neurosci 19(1):93-100 (2001).
84. Martínez-Galan JR, Pedraza P, Santacana M,
Escobar del Ray F, Morreale de Escobar G, Ruiz-Marcos A. Early effects of iodine
deficiency on radial glial cells of the hippocampus of the rat fetus. A model
of neurological cretinism. J Clin Invest 99(11):2701-2709 (1997).
85. McCall MA, Gregg RG, Behringer RR, Brenner M, Delaney
CL, Galbreath EJ, Zhang CL, Pearce RA, Chiu SY, Messing A. Targeted deletion
in astrocyte intermediate filament (Gfap) alters neuronal physiology.
Proc Natl Acad Sci USA 93:6361-6366 (1996).
86. Lima FR, Gervais A, Colin C, Izembart M, Neto VM,
Mallat M. Regulation of microglial development: a novel role for thyroid hormone.
J Neurosci 21(6):2028-2038 (2000).
87. Verity AN, Campagnoni AT. Regional expression of myelin
protein genes in the developing mouse brain: in situ hybridization studies.
J Neurosci 21(2-4):238-248 (1988).
88. Mangelsdorf DJ, Evans RM. The RXR heterodimers and
orphan receptors. Cell 83(6):841-850 (1995).
89. Breen JJ, Hickok NJ, Gurr JA. The rat TSH-beta gene
contains distinct response elements for regulation by retinoids and thyroid
hormone. Mol Cell Endocrinol 131(2):137-146 (1997).
90. Barres BA, Lazar MA, Raff MC. A novel role for thyroid
hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development.
Development 120:1097-1108 (1994).
91. Koibuchi N, Chin WM. ROR
gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone
regulation. Endocrinology 139(5):2335-2341 (1998).
92. Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ,
Klasson-Wehler E, Bergman A, Visser TJ. Interactions of persistent environmental
organohalogens with the thyroid hormone system: mechanisms and possible consequences
for animal and human health. Toxicol Ind Health 14(1-2):59-84 (1998).
93. Brucker-Davis F. Effects of environmental synthetic
chemicals on thyroid function. Thyroid 8(9):827-856 (1998).
94. Wolff J. Perchlorate and the thyroid gland. Pharmacol
Rev 50(1):89-105 (1998).
95. Ram RN, Joy KP, Sathyanesan AG. Cythion-induced histophysiological
changes in thyroid and thyrotrophs of the teleost fish, Channa punctatus
(Bloch). Ecotoxicol Environ Saf 17:272-278 (1989).
96. Goldberg RC, Wolff J, Greep RO. The mechanism of depression
of plasma protein bound iodine by 2,4 dinitrophenol. Endocrinology 56:560-566
(1955).
97. Ealey PA, Henderson B, Loeveridge N. A quantitative
study of peroxidase activity in unfixed tissue sections of the guinea-pig thyroid
gland. Histochem J 16:111-122 (1984).
98. Marinovich M, Guizzetti M, Ghilardi F, Viviani B,
Corsini E, Galli CL. Thyroid peroxidase as toxicity target for dithiocarbamates.
Arch Toxicol 71(8):508-512 (1997).
99. van den Berg KJ, van Raaij JAGM, Bragt PC, Notten
WRF. Interactions of halogenated industrial chemicals with transthyretin and
effects on thyroid hormone levels in vivo. Arch Toxicol 65:15-19 (1991).
100. Maiti PK, Kar A. Dimethoate inhibits extrathyroidal
5'-monodeiodination of thyroxine to 3,3',5-triiodothyronine in mice--the possible
involvement of the lipid peroxidative process. Toxicol Lett 91(1):1-6 (1997).
101. Spear PA, Higueret P, Garcin H. Increased thyroxine
turnover after 3,3',4,4',5,5'-hexabromobiphenyl injection and lack of effect
on peripheral triiodothyronine production. Can J Physiol Pharmacol 68(9):1079-1084
(1990).
102. van Raaij JAGM, Kaptein E, Visser TJ, van den Berg
KJ. Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated
rats. Biochem Pharmacol 45(3):627-631 (1993).
103. Cheek AO, Kow K, Chen J, McLachlan JA. Potential
mechanisms of thyroid disruption in humans: interaction of organochlorine compounds
with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ
Health Perspect 107:273-278 (1999).
104. McKinney J, Fannin R, Jordan S, Chae K, Rickenbacher
U, Pedersen L. Polychlorinated biphenyls and related compound interactions with
specific binding sites for thyroxine in rat liver nuclear extracts. J Med Chem
30:79-86 (1987).
105. Darnerud PO, Morse D, Klasson-Wehler E, Brouwer A.
Binding of a 3,3',4,4'-tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin
and effects on fetal thyroid hormone levels in mice. Toxicology 103(1-3):105-114
(1996).
106. Ghinea E, Dumitriu L, Stefanovici G, Pop A, Oprescu
M, Ciocirdia C. Action of some pesticides on T4 to T3 conversion in cultured
kidney and liver cells in the presence or absence of cysteine. Rev Roum Med
Endocrinol 24(3):157-166 (1986).
107. Morse DC, Koeter HBWM, Smits van Prooijen AE, Brouwer
A. Interference of polychlorinated biphenyls in thyroid hormone metabolism:
possible neurotoxic consequences in fetal and neonatal rats. Chemosphere 25(1-2):165-169
(1992).
108. Seo BW, Li MH, Hansen LG, Moore RW, Peterson RE,
Schantz SL. Effects of gestational and lactational exposure to coplanar polychlorinated
biphenyl (PCB) congeners or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
on thyroid hormone concentrations in weanling rats. Toxicol Lett 75(3): 253-262
(1995).
109. Morse DC, Wehler EK, Wesseling W, Koeman JH, Brouwer
A. Alterations in rat brain thyroid hormone status following pre- and postnatal
exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol Appl Pharm 136(2):269-279
(1996).
110. Porterfield SP. Vulnerability of the developing brain
to thyroid abnormalities: environmental insults to the thyroid system. Environ
Health Perspect 102(suppl 2):125-130 (1994).
111. Zoeller RT, Crofton KM. Thyroid hormone action in
fetal brain development and potential for disruption by environmental chemicals.
Neurotoxicology 21(6):935-945 (2000).
112. Brouwer A, van den Berg KJ. Binding of metabolite
of 3,4,3',4'-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport
by inhibiting the formation of the protein complex carrying both retinol and
thyroxin. Toxicol Appl Pharmacol 85:301-312 (1986).
113. Lecavalier P, Chu I, Yagminas A, Villeneuve DC, Poon
R, Feeley M, Hakansson H, Ahlborg UG, Valli VE, Bergman A, et al.. Subchronic
toxicity of 2,2',3,3',4,4'-hexachlorobiphenyl in rats. J Toxicol Environ Health
51(3):265-277 (1997).
114. Hallgren S, Sinjari T, Hakansson H, Darnerud PO.
Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls
(PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol
75:200-208 (2001).
115. Ng L, Hurley JB, Dierks B, Srinivas M, Salto C, Vennstrom
B, Reh TA, Forrest D. A thyroid hormone receptor that is required for the development
of green cone photoreceptors. Nat Genet 27:94-98 (2001).
116. Blange I, Drvota V, Yen PM, Sylven C. Species differences
in cardiac thyroid hormone receptor isoforms protein abundance. Biol Pharm Bull
20(11):1123-1126 (1997).
117. Sun Z-Q, Ojamaa K, Nakamura TY, Artman M, Klein I,
Coetzee WA. Thyroid hormone increases pacemaker activity in rat neonatal atrial
myocytes. J Mol Cell Cardiol 33:811-824 (2001).
118. Bellman SC, Davies A, Fuggle PW, Grant DB, Smith
I. Mild impairment of neuro-otological function in early treated congenital
hypothyroidism. Arch Dis Child 74(3):215-218 (1996).
119. Debruyne F, Vanderschueren-Lodeweychx M, Bastijns
P. Hearing in congenital hypothyroidism. Audiology 22(4):404-409 (1983).
120. Soriguer F, Millon MC, Munoz R, Mancha I, Siguero
JPL, Aedo MJM, Gomez-Huelga R, Garriga MJ, Rojo-Martinez G, Esteva I, et al.
The auditory threshold in a school-age population is related to iodine intake
and thyroid function. Thyroid 10(11):991-999 (2000).
121. Brucker-Davis F, Skarulis MC, Pikus A, Ishizawar
D, Mastroianni M-A, Koby M, Weintraub BD. Prevalence and mechanisms of hearing
loss in patients with resistance to thyroid hormone. J Clin Endocrinol Metab
81(8):2768-2772 (1996).
122. Forrest D. Editorial: Deafness and goiter: molecular
genetic considerations. J Clin Endocrinol Metab 81(8):2764-2767 (1996).
123. Li D, Henley CM, O'Malley BW Jr. Distortion product
otoacoustic emissions and outer hair cell defects in the hyt/hyt mutant mouse.
Hear Res 138(1-2):65-72 (1999).
124. Forrest D, Erway LC, Ng L, Altschuler R, Curran T.
Thyroid hormone receptor ß is essential for development of auditory function.
Nat Genet 13:354-357 (1996).
125. Rusch A, Erway LC, Oliver D, Vennstrom B, Forrest
D. Thyroid hormone receptor ß-dependent expression of a potassium conductance
in inner hair cells at the onset of hearing. Proc Natl Acad Sci U S A 95(26):15758-15762
(1998).
126. Hebert R, Langlois J-M, Dussault JH. Permanent defects
in rat peripheral auditory function following perinatal hypothyroidism: determination
of a critical period. Dev Brain Res 23:161-170 (1985).
127. Uziel S. Periods of sensitivity to thyroid hormone
during the development of the organ of Corti. Acta Otolaryngol Suppl 429:23-27
(1986).
128. Freeman S, Cherny L, Sohmer H. Thyroxine affects
physiological and morphological development of the ear. Hear Res 97(1-2):19-29
(1996).
129. Goldey ES, Kehn LS, Rehnberg GL, Crofton KM. Effects
of developmental hypothyroidism on auditory and motor function in the rat. Toxicol
Appl Pharmacol 135:67-76 (1995).
130. Knipper M, Zinn C, Maier H, Praetorius M, Rohbock
K, Kopschall I, Zimmermann U. Thyroid hormone deficiency before the onset of
hearing causes irreversible damage to peripheral and central auditory systems.
J Neurophysiol 83(5):3101-3112 (2000).
131. Goldey ES, Kehn LS, Lau C, Rehnberg GL, Crofton KM.
Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduced circulating
thyroid hormone concentrations and causes hearing deficits in rats. Toxicol
Appl Pharmacol 135:77-88 (1995).
132. Herr DW, Goldey ES, Crofton KM. Developmental exposure
to Aroclor 1254 produces low-frequency alterations in adult rat brainstem auditory
evoked responses. Fundam Appl Toxicol 33(1):120-128 (1996).
133. Crofton KM, Ding D, Padich R, Taylor M, Henderson
D. Hearing loss following exposure during development to polychlorinated biphenyls:
a cochlear site of action. Hear Res 144:196-204 (2000).
134. Goldey ES, Crofton KM. Thyroxine replacement attenuates
hypothyroxinemia, hearing loss, and motor deficits following developmental exposure
to Aroclor 1254 in rats. Toxicol Sci 45:94-105 (1998).
135. Chao WY, Hsu CC, Guo YLL. Middle-ear disease in children
exposed prenatally to polychlorinated biphenyls and polychlorinated dibenzofurans.
Arch Environ Health 52(4):257-262 (1997).
136. Clancy B, Darlington RB, Finlay BL. Translating developmental
time across mammalian species. Neuroscience 105(1):7-17 (2001).
137. Florsheim WH, Velcoff SM. Some effects of 2,4-dichlorophenoxyacetic
acid in thyroid function in the rat: effects on iodine accumulation. Endocrinology
71(1):1-6 (1962).
138. Alexander NM. Antithyroid action of 3-amino-1,2,4-triazole.
J Biol Chem 234(1):148-150 (1959).
139. Mayberry WE. Antithyroid effects of 3-amino-1,2,4-trizole.
Proc Soc Exp Biol Med 129(2):551-556 (1968).
140. Kuzan FB, Prahlad KV. The effects of 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydroxy
endo, exo-5,8-dimthionaphthalene (aldrin) and sodium ethylene-bisdithiocarbomate
(Nabam) on the chick. Poult Sci 54:1054-1064 (1975).
141. Hurley PM, Hill RN, Whiting RJ. Mode of carcinogenic
action of pesticides inducing thyroid follicular cell tumors in rodents. Environ
Health Perspect 106:437-445 (1998).
142. Steinhoff D, Weber H, Mohr U, Boehme K. Evaluation
of amitrole (aminotriazole) for potential carcinogenicity in orally dosed rats,
mice, and golden hamsters. Toxicol Appl Pharmacol 69:161-169 (1983).
143. Barter RA, Klaasen CD. Reduction of thyroid hormone
levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase
inducers in rats. Toxicol Appl Pharmacol 128:9-17 (1994).
144. Bastomsky CH. Effects of a polychlorinated biphenyl
mixture (Aroclor 1254) and DDT on biliary thyroxine excretion in rats. Endocrinology
95(4):1150-1155 (1974).
145. Bastomsky CH, Murthy PVN, Banovac K. Alterations
in thyroxine metabolism produced by cutaneous application of microscope immersion
oil: effects due to polychlorinated biphenyls. Endocrinology 98:1309-1314
(1976).
146. Arnott DG, Doniach I. The effect of compounds allied
to resorcinol upon the uptake of radioactive iodine by the thyroid of the rat.
Biochem J 50:473-479 (1952).
147. Singh H, Singh TP. Thyroid activity and TSH potency
of the pituitary gland and blood serum in response to cythion and hexadrin treatment
in the freshwater catfish, Heteropneustes fossilis (Bloch). Environ Res
22:184-189 (1980).
148. Freudenthal RI, Kerchner G, Persing R, Baron RL.
Dietary subacute toxicity of ethylene thiourea in the laboratory rat. J Environ
Pathol Toxicol 1:147-161 (1977).
149. Smith AG, Dinsdale D, Cabral JRP, Wright AL. Goiter
and wasting induced in hamsters by hexachlorobenzene. Arch Toxicol 60:343-349
(1987).
150. Kleiman de Pisarev DL, del Carmen Rios de Molina
M, San Martin de Viale LC. Thyroid function and thyroxine metabolism in hexachlorobenzene-induced
porphyria. Biochem Pharmacol 35(5):817-825 (1990).
151. Goldman M, Dillon RD. Interaction of selenium and
lead on several aspects of thyroid function in Pekin ducklings. Res Commun Chem
Pathol Pharmacol 37(3):487-490 (1982).
152. Kackar R, Srivastava MK, Raizada RB. Studies on rat
thyroid after oral administration of mancozeb: morphological and biochemical
evaluations. J Appl Toxicol 17(6):369-375 (1997).
153. Goldman M, Blackburn P. The effect of mercuric chloride
on thyroid function in the rat. Toxicol Appl Pharmacol 48:49-55 (1979).
154. Kawada J, Nishida M, Yoshimura Y, Mitani K. Effects
of organic and inorganic mercurials on thyroidal functions. J Pharmacobio-Dyn
3:149-159 (1980).
155. Bastomsky CH, Papapetrou PD. The effect of methycholanthrene
on biliary thyroxine excretion in normal and Gunn rats. J Endocrinol 56:367-273
(1973).
156. Lybeck H, Leppaluoto J, Aito H. The influence of
an anticholinesterase, methylparathion, on the radioiodine uptake of the rat
thyroid in vivo and in vitro. Ann Med Exp Biol Fenn 45(1):76-79
(1967).
157. Van Wyk JJ, Arnold MB, Wynn J, Pepper F. The effects
of a soybean product on thyroid function in humans. Pediatrics 24:752-760
(1959).
158. Allen-Rowlands CF, Castracane VD, Hamilton MG, Seifter
J. Effect of polybrominated biphenyls (PBB) on the pituitary-thyroid axis of
the rat (41099). Proc Soc Exp Biol Med 166(4):506-514 (1981).
159. Eskandari S, Loo DD, Dai G, Levy O, Wright EM, Carrasco
N. Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. J Biol
Chem 272(43):27230-27238 (1997).
160. Balasubramanian K, Vijayan AP, Ananthanarayanan PH,
Balasubramanian A. Effect of malathion on the thyroid function of male albino
rats. IRCS Med Sci 14:1139-1140 (1986).
161. Marshall JS, Tompkins LS. Effect of o,p'-DDD and
similar compounds on thyroxine binding globulin. J Clin Endocrinol 28:386-392
(1968).
162. Danowski TS, Sarver ME, Moses C, Bonessi JV. o-p'DDD
therapy in Cushing's syndrome and in obesity with Cushingoid changes. Am J Med
37:235-250 (1964).
163. Bhattacharya T, Bhattacharya S, Ray AK, Dey S. Influence
of industrial pollutants on thyroid function in Channa punctatus (Bloch). Indian
J Exp Biol 27:65-68 (1989).
164. Strum JM, Karnovsky MJ. Aminotriazole goiter. Lab
Invest 24(1):1-12 (1971).
165. Ghosh N, Bhattacharya S. Thyrotoxicity of the chlorides
of cadmium and mercury in rabbit. Biomed Environ Sci 5:236-240 (1992).
166. Sinha N, Lal B, Singh TP. Effect of endosulfan on
thyroid physiology in the freshwater catfish, Clarias batrachus. Toxicology
67:187-197 (1991).
167. Yadav AK, Singh TP. Pesticide-induced impairment
of thyroid physiology in the freshwater catfish, Heteropneustes fossilis.
Environ Poll 43:29-38 (1987).
168. van Raaij JAGM, Frijters CMG, van den Berg KJ. Hexachlorobenzene-induced
hypothyroidism: involvement of different mechanisms by parent compound and metabolite.
Biochem Pharmacol 46(8):1385-1391 (1993).
169. van den Berg KJ. Interaction of chlorinated phenols
with thyroxine binding sites of human transthyretin, albumin and thyroid binding
globulin. Chem Biol Interact 76:63-75 (1990).
170. den Besten C, Vet JJRM, Besselink HT, Kiel GS, Beems
R, van Bladeren PJV. The liver, kidney, and thyroid toxicity of chlorinated
benzenes. Toxicol Appl Pharmacol 111:69-81 (1991).
171. Visser TJ, Kaptein E, van Toor H, van Raaij JAGM,
van den Berg KJ, Joe CTT, van Engelen JGM, Brouwer A. Glucuronidation of thyroid
hormone in rat liver: effects of in vivo treatment with microsomal enzyme
inducers and in vitro assay conditions. Endocrinology 133(5):2177-2186
(1993).
172. de Sandro V, Chevrier M, Boddaert A, Melcion C, Cordier
A, Richert L. Comparison of the effects of propylthiouracil, amiodorane, diphenylhydantoin,
phenobarbital, and 3-methylchloanthrene on hepatic and renal T4 metabolism and
thyroid gland function in rats. Toxicol Appl Pharmacol 111:263-278 (1991).
173. Yoshida K, Sugihira N, Suzuki M, Sakurada T, Saito
S, Yoshinaga K, Saita H. Effect of cadmium on T4 outer ring monodeiodination
by rat liver. Environ Res 42:400-405 (1987).
174. Karabelyos CS, Szeberenyi SZ, Csaba G. Effect of
allylestrenol exposure during pregnancy on the activity of microsomal enzyme
system (PSMO) of rat in the F1 and F2 generations. Acta Physiol Hung 82(1):15-22
(1994).
175. Maiti PK, Kar A, Gupta P, Chaurasia SS. Loss of membrane
integrity and inhibition of type I iodothyronine 5'-monodeiodinase activity
by fenvalerate in female mouse. Biochem Biophys Res Commun 214(3):905-909
(1995).
176. Maiti PK, Kar A. Dual role of testosterone in fenvalerate-treated
mice with respect to thyroid function and lipid peroxidation. J Appl Toxicol
17(2):127-131 (1997).
177. Chaurasia SS, Gupta P, Kar A, Maiti PK. Lead induced
thyroid dysfunction and lipid peroxidation in the fish Clarias batrachus
with special reference to hepatic type I-5'-monodeiodinase activity. Bull Environ
Contam Toxicol 56(4):649-654 (1996).
178. Schuur AG, Boekhorst FM, Brouwer A, Visser TJ. Extrathyroidal
effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone turnover
in male Sprague-Dawley rats. Endocrinology 138(9):3727-3734 (1997).
179. Barter RA, Klaassen CD. UDP-glucuronosyltransferase
inducers reduce thyroid hormone levels in rats by an extrathyroid mechanism.
Toxicol Appl Pharmacol 113:36-42 (1992).
180. Goldstein JA, Taurog A. Enhanced biliary excretion
of thyroxine glucuronide in rats pretreated with benzpyrene. Biochem Pharmacol
17:1049-1065 (1968).
181. Rozman K, Gorski JR, Rozman P, Parkinson A. Reduced
serum thyroid hormone levels in hexachlorobenzene-induced porphyria Toxicol
Lett 30:71-78 (1986).
182. Van Birgelen APJM, Smit EA, Kampen IM, Groeneveld
CN, Fase KM, Van der Kolk J, Poiger H, Van den Berg M, Koeman JH, Brouwer A.
Subchronic effects of 2,3,7,8-TCDD of PCBs on thyroid hormone metabolism: use
in risk assessment. Eur J Pharmacol-Environ Toxicol Pharmacol 293(1):77-85
(1995).
183. McClain RM, Levin AA, Posch R, Downing JC. The effect
of phenobarbital on the metabolism and excretion of thyroxine in rats. Toxicol
Appl Pharmacol 99(2):216-228 (1989).
184. Ringer RK, Polin D. The biological effects of polybrominated
biphenyls in avian species. Fed Proc 36(6):1894-1898 (1977).
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