gamma-Hexachlorocyclohexane (gamma-HCH) (CASRN 58-89-9)
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0065
gamma-Hexachlorocyclohexane (gamma-HCH);
CASRN 58-89-9
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR gamma-HCH
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 03/01/1988 |
Inhalation RfC Assessment (I.B.) | no data | 07/01/1992 |
Carcinogenicity Assessment (II.) | no data | 10/01/1993 |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — gamma-Hexachlorocyclohexane (gamma-HCH)
CASRN — 58-89-9
Primary Synonym — Lindane
Last Revised — 03/01/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Liver and kidney Rat, Subchronic Oral Zoecon Corp., 1983 |
NOAEL: 4 ppm diet LOAEL: 20 ppm diet |
1000 |
1 |
3E-4 mg/kg/day |
*Conversion Factor -- Converted dose calculated from actual food consumption data
__I.A.2. Principal and Supporting Studies (Oral RfD)
Zoecon Corporation. 1983. MRID No. 00128356. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
Twenty male and 20 female Wistar KFM-Han (outbred) SPF rats/treatment group were administered 0, 0.2, 0.8, 4, 20, or 100 ppm lindane (99.85%) in the diet. After 12 weeks, 15 animals/sex/group were sacrificed. The remaining rats were fed the control diet for an additional 6 weeks before sacrifice. No treatment-related effects were noted on mortality, hematology, clinical chemistry, or urinalysis. Rats receiving 20 and 100 ppm lindane were observed to have greater-than-control incidence of the following: liver hypertrophy, kidney tubular degeneration, hyaline droplets, tubular distension, interstitial nephritis, and basophilic tubules. Since these effects were mild or rare in animals receiving 4 ppm, this represents a NOAEL. The reviewers of the study calculated the dose to be 0.29 mg/kg/day for males and 0.33 mg/kg/day for females, based on measured food intake.
In a 2-year feeding study (Fitzhugh, 1950), 10 Wistar rats/sex/group were exposed to 5, 10, 50, 100, 400, 800, or 1600 ppm lindane. Slight liver and kidney damage and increased liver weights were noted at the 100 ppm level. If a food intake equal to 5% body weight is assumed, a NOAEL of 2.5 mg/kg bw/day (50 ppm) can be determined from this assay. In a 2-year bioassay (Rivett et al., 1978), four beagle dogs/sex/group were administered 0, 25, 50, or 100 ppm lindane in the diet. Treatment-related effects noted in the animals of the 100 ppm group were increased serum alkaline phosphatase and enlarged dark friable livers. A NOAEL was determined to be 50 ppm (1.6 mg/kg bw/day).
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — A factor of 10 each was employed for use of a subchronic vs. a lifetime assay, to account for interspecies variation and to protect sensitive human subpopulations.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data on reproductive effects of lindane are inconclusive. Most reports indicate that hexachlorocyclohexane isomers are nonteratogenic.
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Medium
RfD — Medium
The principal study used an adequate number of animals and measured multiple endpoints. Since there are other reported chronic and subchronic studies, confidence in the database is medium. Medium confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — U.S. EPA, 1985
The RfD in the Drinking Water Criteria Document has been extensively reviewed by U.S. EPA scientists and selected outside experts.
Other EPA Documentation — None
Agency Work Group Review — 01/22/1986
Verification Date — 01/22/1986
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — gamma-Hexachlorocyclohexane (gamma-HCH)
CASRN — 58-89-9
Primary Synonym — Lindane
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — gamma-Hexachlorocyclohexane (gamma-HCH)
CASRN — 58-89-9
Primary Synonym — Lindane
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — gamma-Hexachlorocyclohexane (gamma-HCH)
CASRN — 58-89-9
Primary Synonym — Lindane
Last Revised — 08/01/1991
_VI.A. Oral RfD References
Fitzhugh, O.G., A.A. Nelson and J.P. Frawley. 1950. The chronic toxicities of technical benzene hexachloride and its alpha, beta and gamma isomers. J. Pharmacol. Exp. Ther. 100: 59-66.
Muller, D., H. Klepel, R.M. Macholz, H.J. Lewerenz and R. Engst. 1981. Electroneurophysiological studies on neurotoxic effects of hexachlorocyclo- hexane isomers and gamma-pentachlorocyclohexene. Bull. Environ. Contam. Toxicol. 27(5): 704-706.
Rivett, K.F., H. Chesterman, D.N. Kellett, A.J. Newman, and A.N. Worden. 1978. Effects of feeding lindane to dogs for periods of up to 2 years. Toxicology. 9: 273-289.
U.S. EPA. 1985. Drinking Water Criteria Document for Lindane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC.
Zoecon Corporation. 1983. MRID No. 00128356. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — gamma-Hexachlorocyclohexane (gamma-HCH)
CASRN — 58-89-9
Primary Synonym — Lindane
Date |
Section |
Description |
---|---|---|
03/31/1987 | IV.A. | Additional pesticide AI data added |
03/01/1988 | I.A.1. | Principal study citation corrected |
03/01/1988 | I.A.1. | Dose conversion corrected |
03/01/1988 | I.A.2. | Text revised |
03/01/1988 | III.A. | Health Advisory added |
08/01/1990 | III.A.10 | Primary contact changed |
08/01/1990 | IV.F.1. | EPA contact changed |
08/01/1991 | VI. | Bibliography on-line |
01/01/1992 | I.A.7. | Secondary contact changed |
01/01/1992 | IV. | Regulatory actions updated |
07/01/1992 | I.B. | Inhalation RfC now under review |
10/01/1993 | II. | Inadvertently listed as under review |
08/01/1995 | I.B. | EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
01/09/2002 | I.A., II. | This chemical is being reassessed under the IRIS Program. |
02/09/2004 | I.A., II. | This chemical is no longer being reassessed under the IRIS Program. See Federal Register February 9, 2004 (Volume 69, Number 26). |
_VIII. Synonyms
Substance Name — gamma-Hexachlorocyclohexane (gamma-HCH)
CASRN — 58-89-9
Primary Synonym — Lindane
Last Revised — 01/31/1987
- 58-89-9
- AALINDAN
- AFICIDE
- AGRISOL G-20
- AGRONEXIT
- AMEISENATOD
- AMEISENMITTEL MERCK
- APARASIN
- APHTIRIA
- APLIDAL
- ARBITEX
- BBH
- BEN-HEX
- BENTOX 10
- gamma-BENZENE HEXACHLORIDE
- BENZENE HEXACHLORIDE-gamma-isomer
- BEXOL
- BHC
- gamma-BHC
- CELANEX
- CHLORESENE
- CODECHINE
- CYCLOHEXANE, 1,2,3,4,5,6-HEXACHLORO-, gamma-isomer
- DBH
- DETMOL-EXTRAKT
- DETOX 25
- DEVORAN
- DOL GRANULE
- DRILL TOX-SPEZIAL AGLUKON
- ENT 7,796
- ENTOMOXAN
- EXAGAMA
- FORLIN
- GALLOGAMA
- GAMACARBATOX
- GAMACID
- GAMAPHEX
- GAMENE
- GAMISO
- GAMMA-COL
- GAMMAHEXA
- GAMMAHEXANE
- GAMMALIN
- GAMMALIN 20
- GAMMATERR
- GAMMEX
- GAMMEXANE
- GAMMOPAZ
- GEXANE
- HCCH
- HCH
- gamma-HCH
- HECLOTOX
- HEXA
- HEXACHLORAN
- HEXACHLORANE
- gamma-HEXACHLORANE
- gamma-HEXACHLORAN
- gamma-HEXACHLOR
- gamma-HEXACHLOROBENZENE
- 1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE
- 1-alpha,2-alpha,3-beta,4-alpha,5-alpha,6-beta-HEXACHLOROCYCLOHEXANE
- Hexachlorocyclohexane, gamma-
- gamma-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE
- 1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE, gamma-ISOMER
- HEXACHLOROCYCLOHEXANE, gamma-ISOMER
- HEXATOX
- HEXAVERM
- HEXICIDE
- HEXYCLAN
- HGI
- HORTEX
- INEXIT
- ISOTOX
- JACUTIN
- KOKOTINE
- KWELL
- LENDINE
- LENTOX
- LIDENAL
- LINDAFOR
- LINDAGAM
- LINDAGRAIN
- LINDAGRANOX
- Lindane
- gamma-LINDANE
- LINDAPOUDRE
- LINDATOX
- LINDOSEP
- LINTOX
- LOREXANE
- MILBOL 49
- MSZYCOL
- NA 2761
- NCI-C00204
- NEO-SCABICIDOL
- NEXEN FB
- NEXIT
- NEXIT-STARK
- NEXOL-E
- NICOCHLORAN
- NOVIGAM
- OMNITOX
- OWADZIAK
- PEDRACZAK
- PFLANZOL
- QUELLADA
- RCRA WASTE NUMBER U129
- SANG gamma
- SILVANOL
- SPRITZ-RAPIDIN
- SPRUEHPFLANZOL
- STREUNEX
- TAP 85
- TRI-6
- VITON