Testing Information

Testing Status of Agents at NTP

CAS Registry Number: 58-89-9

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http://ntp.niehs.nih.gov/go/23249

Selected information from two of the National Library of Medicine's databases: ChemIDPlus1 and HSDB2.

Names (NTP)

  • Lindane
  • (1ALPHA,2ALPHA,3BETA,4ALPHA,5ALPHA,6BETA)-1,2,3,4,5,6-HEXACHLORO-CYCLOHEXANE (9CI)
  • GAMA-HCH

Structure

Chemical Structure for CAS Registry Number 58-89-9 from NLM

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Chemical Properties2

Property Description
Color/Form
  • White to yellow, crystalline powder
  • Odorless, crystalline soild
  • White, free-flowing crystalline
Odor
  • Slight musty odor
  • Odorless
Taste
  • None found
Boiling Point
  • 323.4 deg C at 760 mm Hg
Melting Point
  • 112.5 deg C
Molecular Weight
  • 290.83
Corrosivity
  • Corrosive to metals.
Critical Temperature & Pressure
  • None found
Density/Specific Gravity
  • 1.85
Disassociation Constants
  • None found
Heat of Combustion
  • None found
Heat of Vaporization
  • None found
log P (octanol-water)
  • log Kow = 3.72
pH
  • None found
Solubilities
  • In water, 7.3 mg/L at 25 deg C
  • In acetone >200, methanol 29-40, xylene 250, ethyl acetate >200, n-heptane 10-14 (all in g/L at 20 deg C).
Spectral Properties
  • Index of refraction: 1.644 at 20 deg C/D
  • SADTLER REFERENCE NUMBER: 9697 (IR, PRISM)
  • Intense mass spectral peaks: 181 m/z (100%), 183 m/z (98%), 109 m/z (98%), 51 m/z (91%)
  • IR: 574 (Sadtler Research Laboratories IR Grating Collection)
  • NMR: 7046 (Sadtler Research Laboratories Spectral Collection)
  • MASS: 53827 (NIST/EPA/MSDC Mass Spectral Data Base, 1990 version)
  • Intense mass spectral peaks: 217 m/z, 252 m/z, 288 m/z
Surface Tension
  • None found
Vapor Density
  • None found
Vapor Pressure
  • 4.20X10-5 mm Hg at 20 deg C
Relative Evaporation Rate
  • 1.5X10-4 m/hr
Viscosity
  • None found
Other Properties
  • Possesses more vapor activity than most organochlorine insecticides.
  • Lindane heated in steam at 102 deg C produced ... 0.13% hydrogen chloride.
  • Vapor pressure: 9.4X10-6 mm Hg @ 20 deg C
  • Extremely stable to light, air, temperatures up to 180 deg C, and to acids. In alkalis undergoes dehydrochlorination
  • Henry's Law constant = 5.14X10-6 atm-cu m/mol at 25 deg C
  • Hydroxyl radical reaction rate constant = 1.90X10-13 atm-cu m/mol at 25 deg C

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Uses2

  • MEDICATION: Pediculicide; scabicide
  • MEDICATION (VET): Ectoparasiticide.
  • ... In humans, lindane is used in lotions, creams, and shampoos to treat scabies and lice ...
  • In the United States , lindane is used as a seed treatment on six agricultural crops: barley, corn, oats, rye, sorghum, and wheat. Depending on existing pest pressures, anywhere from 65 to 105 tons of lindane active ingredient may be used annually for seed treatment. Percent of seeds treated is low (7% for wheat and barley; 1% for oats and rye; 6% for corn; and 1% for sorghum). ... /Former use/
  • This RED Addendum reflects the Agency's conclusions on the remaining lindane seed treatment uses in light of the information gathered since the 2002 RED. The seed treatment use is a source of human exposure to lindane, and it will add to the reservoir of lindane already present in the environment. EPA believes that dietary exposure to lindane from the seed treatment use may pose a risk to nursing infants who consume breast milk contaminated with lindane. EPA, however, is not able to quantify that risk at this time or determine whether current exposures result in any harm. Lindane's persistent and bioaccumulative nature is also of concern to the Agency. In addition, the Agency's updated analysis of the seed treatment use indicates very minor benefits to growers. In light of these factors, EPA now concludes that the six lindane seed treatment uses are ineligible for reregistration. As of July 27, 2006, the Agency had received requests from all lindane technical and end-use product registrants to voluntarily cancel all lindane product registrations. Once the cancellation process is complete, EPA will propose to revoke the existing lindane fat tolerances pursuant to section 408(l)(2) of the Food Quality Protection Act (FQPA).
  • For Lindane (USEPA/OPP Pesticide Code: 009001) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
  • Used in baits & seed treatments for rodent control. /Former use/
  • Insecticide used for control of a broad spectrum of phytophagous and soil-inhabiting insects, public-health pests, and animal ectoparasites. Used on a wide range of crops and in seed treatments. /Former use/
  • Insecticide; Many uses of which seed and soil treatments are prominent. /Former use/
  • Application rates: Range from 0.25 to 2.25 ounces/100 lb of seed for seed treatment; 0.1 to 2.06 lb/acre for foliar and soil treatment; 0.8 to 1.5 oz/50,000 cubic feet of greenhouse; 0.006 to 0.11 lb/gallon for bark; 0.023 to 3% sprays, dips, and dusts for indoor and animal treatment; <0.01 lb/1000 square feet for animal premises; <4 lb/1000 square feet (14.64% solutions) for wood, and wooden structures /Former use/ ...

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Superlist Classes1

  • ATSDR Profile Priority List, rank : 32
  • Reasonably anticipated to be a carcinogen
  • Reportable Quantity (RQ) = 1 lb
  • Threshold Planning Quantity (TPQ) = 1000/10000 lb
  • TWA 0.5 mg/m3; skin; Confirmed animal carcinogen with unknown relevance to humans
  • TWA 0.5 mg/m3; skin

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Notes (Sources: NTP,HSDB,RTECS,MESH)1

  • None found

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Other Registry Numbers1

  • 25897-48-7
  • 53529-37-6
  • 55963-79-6
  • 8007-42-9
  • 8073-23-2

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)1

  • 4-05-00-00058 (Beilstein Handbook Reference)
  • gamma Benzene hexachloride
  • Aalindan
  • Aficide
  • Agrocide
  • Agrocide 6G
  • Agrocide 7
  • Agrocide III
  • Agrocide WP
  • Agronexit
  • Ameisenmittel merck
  • Ameisentod
  • Aparasin
  • Aphtiria
  • Aplidal
  • Arbitex
  • Ben-Hex
  • Benhexol
  • Bentox 10
  • Benzene hexachloride (Ambiguous)
  • Benzene hexachloride-gamma isomer
  • gamma-Benzohexachloride
  • Bexol
  • BRN 1907337
  • Celanex
  • Chloresene
  • Codechine
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, gamma-isomer
  • Detox 25
  • Devoran
  • Dol Granule
  • Drilltox-Spezial Aglukon
  • ENT 7,796
  • Entomoxan
  • Fenoform forte
  • Forst-Nexen
  • Gallogama
  • Gamacarbatox
  • Gamacid
  • Gamaphex
  • Gamene
  • Gamiso
  • Gammalin
  • Gammalin 20
  • Gamma-mean 400
  • Gammaterr
  • Geobilan
  • Geolin G 3
  • Gexane
  • HCCH
  • HCH
  • Heclotox
  • HEXA
  • Hexachloran
  • Hexachlorane
  • gamma-Hexachlorobenzene
  • Hexachlorocyclohexane
  • gamma-1,2,3,4,5,6-Hexachlorocyclohexane
  • Hexachlorocyclohexane, gamma-isomer
  • 1,2,3,4,5,6-Hexachlorocyclohexane, gamma-isomer
  • Hexaverm
  • Hexicide
  • Hexyclan
  • HGI
  • Hilbeech
  • Hortex
  • HSDB 646
  • Hungaria L7
  • Inexit
  • Jacutin
  • Kokotine
  • Kwell
  • Lacco HI lin
  • Lasochron
  • Lendine
  • Lentox
  • Lidenal
  • Lindafor
  • Lindagam
  • Lindagrain
  • Lindagranox
  • Lindane
  • Lindapoudre
  • Lindatox
  • Lindex
  • Lindosep
  • Lintox
  • Linvur
  • Lorexane
  • Mglawik L
  • Milbol 49
  • Mszycol
  • NCI-C00204
  • Neo-Scabicidol
  • Nexen FB
  • Nexit
  • Nexit-stark
  • Nexol-E
  • Nicochloran
  • Novigam
  • Omnitox
  • Ovadziak
  • Owadziak
  • Pedraczak
  • Pflanzol
  • PLK
  • Quellada
  • RCRA waste number U129
  • Sang gamma
  • Silvanol
  • Spritzlindane
  • Spritz-Rapidin
  • Spruehpflanzol
  • Streunex
  • TAP 85
  • Tri-6
  • Verindal Ultra
  • Viton
  • BBH

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Links to Additional Information1

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Footnotes

1 Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

2 Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.

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Web page last updated on May 14, 2008