Ashot Khrimian, Research Chemist
Research Progress and Plans
CRIS Project Number: 1275-22000-134-00DStart Date: 05/24/96 Term Date: 05/20/01
(Replaces CRIS 1275-22000-089-00D)
CRIS Project Title: Discover, Synthesize, Develop Attractants and Behavior-Modifying Chemicals to Manage Insects
Objectives:
- Discover, identify and synthesize potent attractants for tephritid fruit flies of economic importance.
Progress:
- Carries out amenable for industrial scale synthesis of the ethyl(1R, 2R, 5R)-5-iodo-2-methylcyclohexane-1-carboxylate, or active Ceralure B1 isomer, as attractant for the Mediterranean fruit fly. Conservative estimates suggest that this compound is at least 7-10 times more active than trimedlure, a standard lure for male medfly detection. Synthesized multi-gram quantity of Ceralure B1 for the extensive bioassays.
Plans:
- Modify existing synthesis or develop new methodologies applicable for commercialization of ethyl (1R, 2R, 5R)-5-iodo-2-methylcyclohexane-1-carboxylate.
- Utilize (1R, 2R, 5R)-5-iodo-2-methylcyclohexane-1-carboxylate as a lead compound to develop other more potent analogs that could be used in medfly detection and possibly in annihilation.
- Discover, synthesize, and develop semiochemicals to be used for monitoring and suppressing other pest fruit flies, particularly of Anastrepha genera.
COLLABORATORS
Eric Jang, USDA-ARS-PBARC, Hilo, HI. Development of novel attractants for tephritid fruit fly of economic importance.
EDUCATION
| 1972 | B.S., Chemistry, Yerevan State University, Armenia. |
| 1979 | Ph.D., Organic Chemistry, Armenian Academy of Sciences/Yerevan State University, Armenia |
EMPLOYMENT HISTORY
| July 2000-present | Research Associate, USDA-ARS, PSI, ICEL, Beltsville Agricultural Research Center, Beltsville, MD. |
| 1996-2000 | Senior Research Chemist, Halocarbon Products Corporation. North Augusta, SC |
| 1994-1996 | Research Associate, Department of Chemistry, Howard University, Washington, D.C. |
| 1983-1991 | Senior Research Chemist, Institute of Organic Chemistry, Armenian Academy of Sciences Yerevan, Armenia. |
| 1976-1983 | Junior Research Associate, Institute of Organic Chemistry, Armenian Academy of Sciences, Yerevan, Armenia. |
VISITING SCIENTIST EXPERIENCE
| 1991-1994 | USDA-ARS, PSI, ICEL, Beltsville Agricultural Research Center, Beltsville, MD. |
| 1989, 1987 | Institute of Organic Chemistry and Biochemistry, Prague, Czechoslovakia |
| 1983 | National Chemical Laboratory, Poona, India |
PATENTS
- Khrimian, A.P., Karapetyan, A.V., Badanyan, Sh.O. U.S.S.R. SU 706.413 (1979), C.A. 92:146601t. 2,2,6-Trimethyl-2,3-dihydro-4-pyranone.
- Khrimian, A.P., Karapetyan, A.V., Badanyan, Sh.O. U.S.S.R. SU 979.317 (1982), C.A.98:142951h. 2-Methyl-3,5-heptadien-2-ol.
- Khrimian, A.P., Karapetyan, A.V., Badanyan, Sh.O. U.S.S.R. SU 1.018.94 (1983), C.A. 99:194953a. 3(5)-Benzyl-5(3)-methylpyrazole.
- Khrimian, A.P., Makarian, G.M, Gharibian, O.A., Badanyan, Sh.O. U.S.S.R. SU 1.366.505 (1987), C.A. 109:148875d. (±)3,7-Dimethyl-1,5(E),7-octatrien-3-ol.
- Khrimian A.P., Jones, B.M., Production of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether. Halocarbon patent application KGB-224 filed with US Patent and Trademark Office in January, 2000
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