Nelson KE, Kingkeow D, Heilig CM, Suriyanon V, Rungruenthanaki K, Costello C, Duerr A; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. B12723.
Johns Hopkins University, Baltimore, United States
Background: Studies of HIV-1 infected persons from developed western countries mostly infected with subtype B viruses have shown that loss of T-lymphocyte homeostasis occurs 1.5-2.0 years prior to AIDS. However, lymphocyte dynamics have not reported from developing country populations, especially Thais infected with subtype E (CRF01_AE) viruses. Methods: Lymphocyte phenotypes (CD3, CD8, CD4, NK and B cells) were stained using 2-color monoclonal antibodies and quantified by flow cytometry among 331 HIV+ persons enrolled in a couples study in N. Thailand. Piecewise linear splines modeled the associations between lymphocyte levels and time before death. Results: Mean CD3, CD8 and B cell levels showed no temporal associations from 6.5 to 2 years before death but each declined significantly in the 2 years before death. CD3 levels declined 31.0% and CD8 levels declined 24.6% annually in the 2 years before death in contrast, CD4 levels declined 22.1% annually 4.5 - 2years before death. Conclusions: Loss of lymphocyte homeostasis in Thais is similar to that reported from U. S. HIV-1 infected pts, with an earlier decline in CD4 cells among Thais.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antigens, CD3
- Antigens, CD4
- Antigens, CD8
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Flow Cytometry
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- T-Lymphocytes
- Thailand
- immunology
Other ID:
UI: 102277006
From Meeting Abstracts