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Title Target size of the ryanodine receptor from junctional terminal cisternae of sarcoplasmic reticulum
Creator/Author McGrew, S.G. ; Boucek, R.J. Jr. ; McIntyre, J.O. ; Jung, C.Y. ; Fleischer, S.
Publication Date1987 Jun 02
OSTI IdentifierOSTI ID: 6019939
Other Number(s)CODEN: BICHA
Resource TypeJournal Article
Resource RelationBiochemistry ; Vol/Issue: 26:11
Research OrgVanderbilt Univ., Nashville, TN
Subject560120 -- Radiation Effects on Biochemicals, Cells, & Tissue Culture; CHOLINE-- BIOCHEMICAL REACTION KINETICS;CHOLINE-- RECEPTORS;SARCOPLASMIC RETICULUM-- BIOLOGICAL RADIATION EFFECTS; CALCIUM;CELL MEMBRANES;MOLECULAR WEIGHT;MUSCLES;RABBITS
Related SubjectALCOHOLS;ALKALINE EARTH METALS;AMINES;AMMONIUM COMPOUNDS;ANIMALS;BIOLOGICAL EFFECTS;CELL CONSTITUENTS;DRUGS;ELEMENTS;HYDROXY COMPOUNDS;KINETICS;LIPOTROPIC FACTORS;MAMMALS;MEMBRANE PROTEINS;MEMBRANES;METALS;ORGANIC COMPOUNDS;ORGANOIDS;PROTEINS;QUATERNARY COMPOUNDS;RADIATION EFFECTS;REACTION KINETICS;VERTEBRATES
Description/Abstract Target inactivation analysis was carried out on the ryanodine receptor.^This receptor recently has been implicated as the channel involved in the calcium release process in excitation-contraction coupling and was localized to the junctional terminal cisternae of sarcoplasmic reticulum from skeletal muscle.^Irradiation of the junctional terminal cisternae resulted in an exponential decrease in ryanodine binding with radiation dose, thereby consistent with target theory.^The target molecular weight was found to be 138,000 +/- 21,000, i.e., smaller than the polypeptide that binds ryanodine.^The calcium pump protein in the same membrane preparation served as an internal control to validate the methodology.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 3183-3187
System Entry Date2001 May 13

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