Sunday, November 4

Arrival

Monday, November 5

8:45 a.m.
Welcome
Paul Krebsbach and Lynda Bonewald

9:00 a.m.
Imaging of Mineralized Tissue/Mechanisms of Mineralization
Co-Chairs: Adele Boskey-Intro
Art Veis-Summary

Introduction and Overview
Adele Boskey

9:10 a.m.
Imaging of Mineralization Dynamics and Its Integration with Osteoblast to Osteocyte Transition
Sarah L. Dallas1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Patricia A. Veno1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Jennifer L. Rosser1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
David W. Rowe
niversity of Connecticut Health Center, Farmington, Connecticut
Ivo Kalajzic
niversity of Connecticut Health Center, Farmington, Connecticut
Lynda F. Bonewald1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri

9:30 a.m.
The Composition of Bovine Peritubular Dentin (PTD): Matching TOF-SIMS, SEM and Biochemical Component Distributions. New Light on PTD Function
Bat Ami Gotliv1
Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
Arthur Veis
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

9:50 a.m.
Mineral Deposition in the Extracellular Matrices of Vertebrate Tissues: Identification of Possible Apatite Nucleation Sites on Type I Collagen
*William J. Landis1
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
Frederick J. Silver
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry, New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey

10:10 a.m.
Nucleation of Mineral Crystals within Biomineralization Foci Requires Serine Protease SKI-1 (site-1)
Jeff P. Gorski1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Nichole Huffman1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Ellen Henderson1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Sangmu Cui1
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Ron J. Midura
Lerner Institute, Cleveland Clinic Foundation, Cleveland, Ohio

10:50 a.m.
Exercise Alters Mineral and Matrix Composition in the Absence of Adding New Bone David H. Kohn
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan
Nadder D. Sahar
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan
Kurtulus Golcuk
Department of Chemistry, University of Michigan, Ann Arbor, Michigan
Michael D. Morris
Department of Chemistry, University of Michigan, Ann Arbor, Michigan

11:10 a.m.
Matrix-Mineral Relationships and Structure in the Avian Eggshell, and Effects of Osteopontin and Poly-Asp Peptide on Calcite Crystal Growth
Y.C. Chien1
Faculty of Dentistry, McGill University, Montreal, Quebec City , Canada
V. Nelea1
Faculty of Dentistry, McGill University, Montreal, Quebec City
M.T. Hincke
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
J. Gautron
INRA, Unité de Recherches Avicoles, Nouzilly, France
H. Vali1
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec City, Canada
M.D. McKee1
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec City, Canada

11:30 a.m.
Factors Influencing Calcium Oxalate Crystallization within the Kidney-like Malpighian Tubules of Silkworm (Bombyx mori)
Aaron J. Wyman1
Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana
Mary Alice Webb1
Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana

11:50 a.m.
Questions/Highlight/Summary
Co-Chair: Art Veis

2:00 p.m.
The Role of Phosphate in Biomineralization
Chair: Harvey Goldberg
Co-chair Graeme Hunter

2:00 p.m.
Role of Phosphate Groups in Inhibition of Calcium Oxalate Crystal Growth by Osteopontin
*Graeme K. Hunter
School of Dentistry and Department of Biochemistry-University of Western Ontario, London, Ontario, Canada
Bernd Grohe1
University of Western Ontario, London, Ontario, Canada
Jason O’Young
School of Dentistry and Department of Biochemistry-University of Western Ontario, London, Ontario, Canada
Kem Rogers
Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
Gilles A. Lajoie
Department of Biochemistry-University of Western Ontario, London, Ontario, Canada
Esben S. Sørensen
Department of Molecular Biology, University of Aarhus, Arhus C, Denmark
and Harvey A. Goldberg
School of Dentistry and Department of Biochemistry-University of Western Ontario, London, Ontario, Canada

2:20 p.m.
Molecular Dynamics Simulations of Osteopontin Peptide Adsorption to a Calcium Oxalate Crystal Face
Jason O’Young
School of Dentistry and Department of Biochemistry-University of Western Ontario, London, Ontario, Canada
Bernd Grohe
School of Dentistry-University of Western Ontario, London, Ontario, Canada
Mikko Karttunen
Department of Applied Mathematics-University of Western Ontario, London, Ontario, Canada
Harvey A. Goldberg
School of Dentistry and Department of Biochemistry-University of Western Ontario, London, Ontario, Canada
Graeme K. Hunter
School of Dentistry and Department of Biochemistry -University of Western Ontario, London, Ontario, Canada

2:40 p.m.
Inhibition of Phosphate Induced Apoptosis in Resting Zone Chondrocytes by Thrombin Peptide 508
Ming Zhong
Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia
Laurel J. Wike
Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia
Darrell H. Carney
University of Texas Medical Branch, Galveston, Texas
James T. Ryaby
Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia Zvi Schwartz
Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia Barbara D. Boyan
Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia

3:00 p.m.
Effect of Dentin Phosphoprotein on Phosphate-Induced Apoptosis of Odontoblast-Like Cells
Ryuichi Fujisawa1
Department of Biochemistry and Molecular Biology, School of Dentistry, Hokkaido University, Sapporo, Japan
Morimichi Mizuno1
Department of Biochemistry and Molecular Biology, School of Dentistry, Hokkaido University, Sapporo, Japan
Masato Tamura1
Department of Biochemistry and Molecular Biology, School of Dentistry, Hokkaido University, Sapporo, Japan

3:20 p.m.
Autophagy: a New Phase in the Maturation of Growth Plate Chondrocytes is Regulated by HIF, mTOR and AMP Kinase (AMPK)
Vickram Srinivas1
Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
Jolene Bohensky1
Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania
Irving M. Shapiro1
Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania

4:00 p.m.
Biomineralization Workshop: Different Means to an End with Underlying Themes?
Chair-Lynda F. Bonewald-Intro
Panelists-Ron Midura
Jeff Gorski
Barbara Boyan
Art Vies

4:00 p.m.
Introduction
Chair- Lynda F. Bonewald

4:10 p.m.
1a,25(OH)2D3 is an Autocrine Regulator of ECM Turnover and Growth Factor Release via ERp60 Activated Matrix Vesicle MMPs
Barbara D. Boyan
Georgia Institute of Technology, Atlanta, Georgia
M. Fang
Georgia Institute of Technology, Atlanta, Georgia
Z. Schwartz
Georgia Institute of Technology, Atlanta, Georgia

4:25 p.m.
Calcospherulites Isolated from the Mineralization Front of Bone Promote Type I Collagen Mineralization
Ronald J. Midura1
Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
Amit Vasanji
Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
Xiaowei Su
Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
Aimin Wang
Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
Sharon B. Midura
Department of Biomedical Engineering and The Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
and Jeff P. Gorski
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri

4:40 p.m.
List of Potential Questions
Bonewald

4:45 p.m.
Questions from Audience for Panel/Discussion

5:20 p.m.
Summary
Bonewald

7:00 p.m.
Poster Session
Judges for Best Posters
Chair Zvi Schwartz
Judges: Marian Young
Mary MacDougal
Helena Ritchie
Marc McKee
Yorimasa Ogata

Tuesday, November 6

9:00 a.m.
Signaling/Molecular Mechanisms in Biomineralization
Chair- Trudy Roach
Co-chair, Rena D’Souza

Introduction Chair: Trudy Roach

9:10 a.m.
Genotype-Phenotype Correlations in PAX9 Mutations
Hitesh Kapadia
Baylor College of Dentistry, Dallas, Texas
Takuya Ogawa
Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan Adriana Cavender
Baylor College of Dentistry, Dallas, Texas
Rena D'Souza
Baylor College of Dentistry, Dallas, Texas

9:30 a.m.
Runx2 Mediates FGF2 Stimulated Expression of the Pyrophosphate Generating Enzyme, PC-1, in Osteoblastic Cells, University of Michigan, Ann Arbor, Michigan
Nan Hatch
Orthodontics and Pediatric Dentistry
Hernan Roca
Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor, Michigan
Renny T. Franceschi
Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor, Michigan

9:50 a.m.
Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
Carl-Magnus Bäckesjö
Center for Oral Biology, Karolinska Institutet, SE-141 04 Huddinge, Sweden
Yan Li
Department for Clinical Science, Intervention and Technology (CLINTEC), Division of Orthopedics, Karolinska Institutet, SE-141 86 Huddinge, Sweden
Urban Lindgren
Department for Clinical Science, Intervention and Technology (CLINTEC), Division of Orthopedics, Karolinska Institutet, SE-141 86 Huddinge, Sweden
Lars-Arne Haldosén

10:10 a.m.
Identifying Elements Required for Enamelin Tissue-Specific Expression
Petros Papagerakis1
Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, Michigan
Yuan Yuan Hu1
Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, Michigan
Jan C-C. Hu1
Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, Michigan

10:50 a.m.
Expansion of NFI-C Gene and Alternative Splicing
Ejvis Lamani
University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama
Yixin Wu
University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama
Juan Dong
Ana Carolina Acevedo
University of Brasilia, Brasilia, Brazil
Mary MacDougall
University of Alabama at Birmingham School of Dentistry, Birmingham, Alabama 1University of

11:10 a.m.
Ameloblasts Express the Endocytic Receptor Complex, Cubam, and Are Abundant in Lysosomal Enzymes
Coralee E. Tye
Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts
Rachel L. Lorenz
Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts
John D. Bartlett
Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts

11:30 a.m.
Msx1 Expression Regulation by its Own Antisense RNA. Consequence on Tooth Development and Bone Regeneration
Sylvie Babajko
Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratoire de biologie et pathologie oro-faciale, Paris, France
Stéphane Petit
Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratoire de biologie et pathologie oro-faciale, Paris, France
Isabelle Fernandes
Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratoire de biologie et pathologie oro-faciale, Paris, France
Fleur Méary
Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratoire de biologie et pathologie oro-faciale, Paris, France
Laurence Pibouin
Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratoire de biologie et pathologie oro-faciale, Paris, France
Ariane Berdal1
Centre de Recherche des Cordeliers, INSERM UMRS 872, Laboratoire de biologie et pathologie oro-faciale, Paris, France

11:50 a.m.
Questions/Highlight/Summary
Co-chair: Rena D-Souza

2:00 p.m.
Osteogenesis
Chairs: Jane Lian and Renny Franceschi

A Regulatory Network of Hox, Homeodomain, and Runx Factors Controls Development of the Osteoblast Phenotype
Jane B. Lian
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts
Mohammed Q. Hassan
Gary S. Stein
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts
Janet L. Stein
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts
Andre J. van Wijnen
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts

2:20 p.m.
Differential Impact of Msx1 and Msx2 Homeogenes on the Adult Mouse Maxillo-Facial Skeleton
Ariane Berdal
Cordeliers Research Center INSERM UMRS 872, Universities Paris 5, 6 and 7, France
Muriel Molla
Cordeliers Research Center INSERM UMRS 872, Universities Paris 5, 6 and 7, France
Dominique Hotton
Cordeliers Research Center INSERM UMRS 872, Universities Paris 5, 6 and 7, France Arnaud Marchadier
Muhanad Aïoub
Cordeliers Research Center INSERM UMRS 872, Universities Paris 5, 6 and 7, France
Claude Laurent Benhamou
INSERM U658, Orléans, France
Frédéric Lézot
Cordeliers Research Center INSERM UMRS 872, Universities Paris 5, 6 and 7, France Jean-Raphaël Néfussi
Cordeliers Research Center INSERM UMRS 872, Universities Paris 5, 6 and 7, France

2:40 p.m.
Specific Residues of Runx2 are Obligatory for Functional Coupling of BMP2 Osteogenic Signal and Osteoblast Differentiation
Amjad Javed
Institute of Oral Health Research, University of Alabama School of Dentistry, Birmingham, Alabama
Jong-Sup Bae
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Faiza Afzal
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Soraya Gutierrez
Departamento Biologia Molecular, Universidad de Concepcion, Concepcion, Chile Kaleem Zaidi
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Jitesh Pratap
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Andre J. van Wijnen
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Janet L. Stein
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Gary S. Stein
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts Jane B. Lian
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts

3:00 p.m.
Bone Sialoprotein Regulates Osteoblast Differentiation through Activation of MAP Kinase and Smad Pathways
Jonathan A.R. Gordon
CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Graeme K. Hunter
CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Harvey A. Goldberg
CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

3:20 p.m.
Transcriptional Control of Osteoblast Activity
Renny T. Franceschi
University of Michigan School of Dentistry, Ann Arbor, Michigan
Chunxi Ge
University of Michigan School of Dentistry, Ann Arbor, Michigan
Guozhi Xiao
University of Pittsburg School of Medicine, Pittsburg, Pennsylvania
Hernan Roca
University of Michigan School of Dentistry, Ann Arbor, Michigan
Di Jiang
University of Michigan School of Dentistry, Ann Arbor, Michigan

4:00 p.m.
The Potential Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells
Colette A. Inkson
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Maryland
Yanming Bi
Sergei A. Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Maryland
Marian F.Young
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS Bethesda, Maryland

4:20 p.m.
Progressive Ankylosis Gene (ank) Regulates Osteoblast Differentiation
Thorsten Kirsch
Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
Hyon Jong Kim
Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland
Jeffrey A. Winkles
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland

4:40 p.m.
Activation of Col1a1-3.6GFP Transgene in Odontoblast Differentiation from Dental Pulp Progenitors
Anamaria Balic1
Division of Pediatric Dentistry, Department of Craniofacial Sciences, School of Dental Medicine. University of Connecticut Health Center. Farmington, Connecticut
Alen Braut1
Division of Pediatric Dentistry, Department of Craniofacial Sciences, School of Dental Medicine. University of Connecticut Health Center. Farmington, Connecticut
Mina Mina1
Division of Pediatric Dentistry, Department of Craniofacial Sciences, School of Dental Medicine. University of Connecticut Health Center. Farmington, Connecticut

4:55 p.m.
Questions/Highlight/Summary
Co-chair-Renny Franceschi

7:00 p.m.
Osteonecrosis of the Jaw, ONJ, Workshop

Overview Review of ASBMR Report on Osteonecrosis of the Jaw Due to High Dose Bisphosphonates
Laurey McCauley
University of Michigan, Department of Periodontics and Oral Medicine, and Department of Pathology

7:20 p.m.
Clinical Cases Bisphosphonate Associated Osteonecrosis of the Jaw in the Metastatic Cancer Population; Diagnosis with Cone Beam Computerized Tomography (CBCT)
Cielo Barragan-Adjemian
Special Patient Care Clinic and Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Leonard L. Lausten
Special Patient Care Clinic, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Mark L. Johnson
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Jerald O. Katz
Department of Radiology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Lynda F. Bonewald
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri

7:40 p.m.
Bisphosphonates and Osteonecrosis of the Jaw: Moving From the Clinic to the Lab
Matthew R. Allen, Ph.D.
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indianapolis

8:00 p.m.
Discussion/Additional Information

Wednesday, November 7 9:00 a.m.
The Role of Extracellular Matrix Proteins in Biomineralization
Chairs: Carolyn Gibson and Jim Simmer

9:00 a.m.
Two Amelogenin Proteins Partially Rescue the Amelogenin Null Enamel Phenotype
Carolyn W. Gibson
University of Pennsylvania, Philadelphia, Pennsylvania
Yong Li
University of Pennsylvania, Philadelphia, Pennsylvania
Bill Daly
University of North Carolina, Chapel Hill, Northa Carolina
Cynthia Suggs
University of North Carolina, Chapel Hill, Northa Carolina
Zhi-an Yuan
University of Pennsylvania, Philadelphia, Pennsylvania
Melissa Aragon
University of Pennsylvania, Philadelphia, Pennsylvania
Ashok B. Kulkarni
National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland
J. Timothy Wright
University of North Carolina, Chapel Hill, Northa Carolina

9:20 a.m.
The DMP1 C-terminal Fragment Recapitulates All Functions of Full Length DMP1 in Odontogenesis and Osteogenesis In Vivo
Yongbo Lu
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Y. Xie
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas
S. Yu
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas Chunlin Qin
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas Lynda F. Bonewald
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Jian Q. Feng
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas

9:40 a.m.
The NH2-Terminal and COOH-Terminal Fragments of Dentin Matrix Protein 1 (DMP1) are Localized Differently in Bone or Dentin
Izabela Maciejewska
Baylor College of Dentistry, Texas A & M University System Health Science Center, Dallas, Texas and Department of Oral Implantology, Medical University of Gdansk, Poland Disheng Qin
Baylor College of Dentistry, Texas A & M University System Health Science Center, Dallas, Texas
Bingzhen Huang
Baylor College of Dentistry, Texas A & M University System Health Science Center, Dallas, Texas
Lynda F. Bonewald
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
William T Butler
Baylor College of Dentistry, Texas A & M University System Health Science Center, Dallas, Texas
Chunlin Qin
Baylor College of Dentistry, Texas A & M University System Health Science Center, Dallas, Texas

10:00 a.m.
Blocking of Proteolytic Processing and Deletion of Glycosaminoglycan Side Chain of Mouse Dmp1 by Substituting Critical Amino Acid Residures
Tao Peng
Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas
Bingzhen Huang
Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas
Yongo Lu
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri
Lynda F. Bonewald
Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouribr> William T. Butler
Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas
Jian Feng
Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas and Department of Oral Biology, University of Missouri-Kansas City, School of Dentistry, Kansas City, Missouri Chunlin Qin
Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, Texas

10:20 a.m.
Fibromodulin-deficient Mice Reveal Dual Functions for Fibromodulin in Regulating Dental Tissue and Alveolar Bone Formation
Michel Goldberg
Laboratoire Réparation et Remodelage des Tissues Orofaciaux EA 2496 Fac Chir Dent Univ Paris Descartes, Montrouge, France
Dominique Septier
Laboratoire Réparation et Remodelage des Tissues Orofaciaux EA 2496 Fac Chir Dent Univ Paris Descartes, Montrouge, France
Mireille Bonnefoix
Laboratoire Réparation et Remodelage des Tissues Orofaciaux EA 2496 Fac Chir Dent Univ Paris Descartes, Montrouge, France
Tina M. Kilts
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda Maryland
Yanming Bi
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda Maryland
Mildred Embree
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda Maryland
Marian F. Young
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda Maryland

11:00 a.m.
Defective Mineralization in Fibrillin 1 Knockout Mice
Minwook Kim
Musculoskeletal Imaging and Spectroscopy Laboratory, Hospital for Special Surgery, New York, New York
Sui Lee-Arteaga
Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey
Francesco Ramirez
Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey
Nancy Pleshko Camacho
Musculoskeletal Imaging and Spectroscopy Laboratory, Hospital for Special Surgery, New York, New York

11:20 a.m.
The Role of Prolines in Amelogenin Adsorption to Apatite Crystals, and Degradation by MMP-20
Wu Li
University of California at San Francisco
Li Zhu
University of California at San Francisco
Kotaro Tanimoto
University of California at San Francisco
Thuan Le1
University of California at San Francisco
Halina Ewa Witkowski
University of California at San Francisco
Steven Hall
University of California at San Francisco
Sarah Robinson
University of California at San Francisco
Stefan Habelitz
University of California at San Francisco
Pamela Denbesten
University of California at San Francisco

11:40 a.m.
Molecular Localization of Amelogenin and Ameloblastin Revealed by Immunogold Labeling and Field Emission Scanning Electron Microscopy (FESEM)
Chang Du
Li-Sha Chen
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California
Daming Fan
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California
Zhi Sun
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California
Yuwei Fan
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California
Rajamani Lakshminarayanan
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California
Maggie Zeichner-David
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California
Janet Moradian-Oldak
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California

11:55 a.m.
Questions/Highlight/Summary
Co-chair: Jim Simmer

2:00 p.m.
Genetics of Diseases of Mineralized Tissues
Chairs: Michel Goldberg, Michael Paine

Introduction
Chair: M. Goldberg

2:10 p.m.
Impaired Bone Formation and Disrupted Bone Quality in Sh3bp2 Knock-in Mouse Model for Cherubism
Chiachien J. Wang
Center for Restorative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut
Padma M. Mukherjee
Center for Restorative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut
I-Ping Chen
Center for Restorative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut
Adele L. Boskey
Hospital for Special Surgery-Weill Medical College, Cornell University, New York, New York
Yasuyoshi Ueki
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts
Ernst J. Reichenberger1
Center for Restorative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, Connecticut

2:30 p.m.
Homology Modeling of ACVR1 Mutations Linked to Atypical and Variant FOP Syndromes
Jay C. Groppe
Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, Texas
Eileen M. Shore
Departments of Orthopaedics and Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Frederick S. Kaplan
Departments of Orthopaedics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

2:50 p.m.
Detection of Dental Fluorosis Associated QTL on Mouse Chromosomes 2 and 11
Eric T. Everett
Department of Pediatric Dentistry and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina
Dong Yan
Dental Research Center, University of North Carolina, Chapel Hill, North Carolina
Marjorie Weaver
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indianapolis
Lixiang Liu
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indianapolis
Tatiana Foroud
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indianapolis

3:10 p.m.
Dentin Anomalies in Patients with Familial Hypophosphatemic Vitamin D Resistant Rickets Celine Gaucher
Hôpital Bretonneau, AP-HP, Paris 18ème, France
EA 2496 Groupe Matrices extracellulaires et biominéralisation, Faculté de Chirurgie Dentaire, Université Paris 5, Inserm U561, Hôpital St Vincent de Paul, Paris 14ème and Tchilalo Boukpessi
EA 2496 Groupe Matrices extracellulaires et biominéralisation, Faculté de Chirurgie Dentaire, Université Paris 5 and Hôpital Bretonneau, AP-HP, Paris 18ème, France
Dominique Septier
EA 2496 Groupe Matrices extracellulaires et biominéralisation, Faculté de Chirurgie Dentaire, Université Paris 5
Fréderic Jehan
Inserm U561, Hôpital St Vincent de Paul, Paris 14ème Peter S. Rowe
The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas
Michèle Garabédian
Inserm U561, Hôpital St Vincent de Paul, Paris 14ème
Michel Goldberg
EA 2496 Groupe Matrices extracellulaires et biominéralisation, Faculté de Chirurgie Dentaire, Université Paris 5
Catherine Chaussain-Miller
EA 2496 Groupe Matrices extracellulaires et biominéralisation, Faculté de Chirurgie Dentaire, Université Paris 5 and Hôpital Bretonneau, AP-HP, Paris 18ème, France

3:50 p.m.
Human and Mouse Enamel Phenotypes Resulting from Mutation or Altered Expression of AMEL, ENAM, MMP20 and KLK4
J. Timothy Wright
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, North Carolina, 2NIDCR
Tom Hart
NIDCR and HGP, NIH, Bethesda Maryland
Suzanne Hart
NIDCR and HGP, NIH, Bethesda Maryland
Darrin Simmons
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, North Carolina, 2NIDCR
Cynthia Suggs
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, North Carolina, 2NIDCR
Bill Daley
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill, North Carolina, 2NIDCR
Jim Simmer
Departments of Restorative and Pediatric Dentistry, University of Michigan, Ann Arbor, Michigan
Jan Hu
Departments of Restorative and Pediatric Dentistry, University of Michigan, Ann Arbor, Michigan
John Bartlett
Forsyth Institute, Boston, Massachusetts
Yong Li
Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania
Zhi-An Yuan
Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania
Carolyn W. Gibson
Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania

4:10 p.m.
Phenotype Characterization and DSPP Mutational Analysis in Three Brazilian Families with Dentinogenesis Imperfecta Type II
A.C. Acevedo
Dental Anomalies Clinic, Dentistry School, Oral Health Faculty, University o Brasilia, Brazil
L.J.S. Santos
Dental Anomalies Clinic, Dentistry School, Oral Health Faculty, University o Brasilia, Brazil
L.M. Paula
Dental Anomalies Clinic, Dentistry School, Oral Health Faculty, University o Brasilia, Brazil
J. Dong
Institute of Oral Health , Dentistry School, University of Alabama at Birmingham, Birmingham, Alabama
M MacDougall
Institute of Oral Health , Dentistry School, University of Alabama at Birmingham, Birmingham, Alabama

4:30 p.m.
Genetic Variation in Mouse Femoral Tissue-level Mineral Content Underlies Differences in Whole Bone Mechanical Properties
Hayden-William Courtland1
Mila Spevak
Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, New York
Adele L. Boskey
Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, New York
Karl J. Jepsen
Leni and Peter W. May Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York

4:50 p.m.
Questions/Highlight/Summary
Co-Chair: Michael Paine

Thursday, November 8

9:00 a.m.
Chemistry of Synthetic Mimetics of Biomineralized Matrices
Chairs: Bill Landis and K.M. Galler

Advances in Tissue Engineering Models of Human Digits: Mediation of Growth Plate Cartilage by Periosteum
William J. Landis
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
Robin Jacquet
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
Elizabeth Lowder
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
Mitsuhiro Enjo
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio and Department of Plastic and Reconstructive Surgery, Kinki University Medical School, Osaka, Japan
Yoshitaka Wada
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio and Department of Plastic and Reconstructive Surgery, Kinki University Medical School, Osaka, Japan
Noritaka Isogai
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio and Department of Plastic and Reconstructive Surgery, Kinki University Medical School, Osaka, Japan

9:20 a.m.
Identification of Peptides with Targeted Adhesion to Bone-Like Mineral Biomaterials
Sharon Segvich
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan Subhashis Biswas
Department of Geological Sciences, University of Michigan, Ann Arbor, Michigan Udo Becker
Department of Geological Sciences, University of Michigan, Ann Arbor, Michigan David H. Kohn
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan

9:40 a.m.
Cell Derived Heirarchical Assembly of a Novel Phosphophoryn Based Biomaterial
Charles Sfeir
Dana Olton
Donghyun Lee
Jinhua Li
Prashant Kumta
Center for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh and Departments of Materials Science and Engineering and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania

10:00 a.m.
Clonal Cell Lines Isolated from Mouse Dental Pulp Behave a Either Monopotent or Multipotent Progenitors In Vitro and Contribute to Reparative Dentin Formation after Implantation in the Mouse Incisor
S. Lacerda-Pinheiro
Laboratoire de Différenciation, Cellules Souches et Prions, CNRS-FRE2937 Villejuif–France
Y. Harichane
Laboratoire de Différenciation, Cellules Souches et Prions, CNRS-FRE2937 Villejuif–France
A. Baudry
Laboratoire de Différenciation, Cellules Souches et Prions, CNRS-FRE2937 Villejuif–France
D. Septier
Faculté de Chirurgie Dentaire, Université Paris-Descartes 92120 Montrouge France M. Goldberg
Faculté de Chirurgie Dentaire, Université Paris-Descartes 92120 Montrouge France O. Kellermann
Laboratoire de Différenciation, Cellules Souches et Prions, CNRS-FRE2937 Villejuif–France
A Poliard
Laboratoire de Différenciation, Cellules Souches et Prions, CNRS-FRE2937 Villejuif–France

10:20 a.m.
Human Embryonic Stem Cells Undergo Osteogenic Differentiation in Mesenchymal Stem Cell Microenvironments
Shelley Brown
Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, Michigan and Biomedical Engineering Department, University of Michigan College of Engineering, Ann Arbor, Michigan Wilbur Tong
Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, Michigan
Paul H. Krebsbach
Biologic and Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, Michigan and Biomedical Engineering Department, University of Michigan College of Engineering, Ann Arbor, Michigan

11:00 a.m.
Subcultured Dental Enamel Organ Epithelial Cells in Combination with Dental Papilla Cells Produce Enamel-dentin-like Complexes Structures
Masaki Honda1
Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo
Yoshinori Shinohara1
Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo
Ken-ichiro Hata
Japan Tissue Engineering Co. Ltd. Minoru Ueda
Division of Stem Cell Engineering, The Institute of Medical Science, The University of Tokyo

11:20 a.m.
Isolation of Distinct Progenitor Stem Cell Populations from Dental Pulp
Rachel Waddington
Sarah Youde
Alastair Sloan
Matrix Biology and Tissue Repair Research Group, School of Dentistry, Cardiff University, Cardiff, United Kingdom

11:40am
Questions/Highlight/Summary
Co-chair: K. M. Galler

12:00 noon
Summary/Conclusion Krebsbach/Bonewald

Final Comments
Boskey

Back to Scientific Conferences Home

Last Reviewed: January 30, 2008