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Title INVESTIGATION OF ACYLATED GEMINAL DIAMINES. PREPARATION OF $alpha$-AMINOACIDS LABELLED WITH $sup 14$C IN THE CARBOXYL GROUP
Creator/Author Egyed, J. ; Meisel-Agoston, J. ; Oetvoes, L.
Publication Date1963 Jan 01
OSTI IdentifierOSTI ID: 4169867
Other Number(s)CODEN: ACASA; 0001-5407
Resource TypeJournal Article
Resource RelationActa Chimica Academiae Scientiarum Hungaricae (Hungary); Vol: 38
Research OrgCentral Research Inst. for Chemistry, Hungarian Academy of Sciences, Budapest
SubjectCHEMISTRY; ALANINE; AMINO ACIDS; AROMATICS; AZIDES; CARBON 14; CARBONATES; CHEMICAL REACTIONS; CRACKING; CYANIDES; DECOMPOSITION; DECONTAMINATION; ENERGY; FUEL ELEMENTS; HYDROLYSIS; IMPREGNATION; IONIZATION; IRRADIATION; ISOTOPIC EXCHANGE; LABELLED COMPOUNDS; LIQUIDS; LOSSES; MELTING POINTS; NITRIDES; NITRILES; ORGANIC NITROGEN COMPOUNDS; PAPER; PETROLEUM; PHENYL RADICALS; PHTHALIC ACID; POLYMERIZATION; POLYMERS; PREPARATION; PRODUCTION; PROPULSION; RADIATIONS; REACTION KINETICS; RESINS; SOLIDS; STEAM; THERMODYNAMICS; USES; VALINE; VINYL RADICALS
Description/Abstract A new general method was developed for the synthesis of 1-C/sup 14/-amino acids. Essentially, the method consists of the exchange of the carboxyl group of the aminoacid by a C/sup 14/-carboxyl group through a reaction cycle. Starting from a given amino acid, first the N-phthaloyl, then from this latter the chloride, further the azide derivatives are prepared. Subjecting the azide derivatives to a Curtius decomposition, a carbamic acid derivative was obtained whose phthalimide group could be exchanged by a labeled cyanide-group. The hydrolysis of the formed nitrile derivative affords the desired labeled amino acid. It was possible to prepare DL-alanine-l-C/sup 14/ in a yield of 69.2%, l-C/sup 14/ in yield of 43.5%. (auth)
LanguageEnglish
FormatPages: 123-8
System Entry Date2001 Jun 03

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