W. M. Wood-Vasey Harvard University Determining the Nature of Dark Energy: Cosmology with ESSENCE, Pan-STARRS, SPT, LSST, and Other Acronyms Solving the mystery of the dark energy accelerating the expansion of our Universe is quite arguably the greatest challenge facing the astronomical and physics communities today. Our group at Harvard is attacking this problem through several complementary observational programs. I will begin my talk by presenting the first cosmological results from the ESSENCE supernova survey, which is a six-year project on the CTIO 4-m telescope to discover and study 200 Type Ia supernovae to determine the properties of dark energy. After discussing the expectations for the final six-year ESSENCE cosmological results, I will describe a complementary program we are starting to further constrain the properties of dark energy by measuring photometric redshifts, X-ray luminosities, and lensing properties of clusters from the South Pole Telescope Sunyaev-Zel'dovich effect survey. I will spend the remainder of the time focusing on the challenges and opportunities for observational constraints on dark energy in upcoming large-scale surveys such as Pan-STARRS and LSST.