Inhibition by Aspirin of Release of Antiheparin Activity from Human Platelets

Br Med J. 1969 August 16; 3(5667): 394–396.

PMCID: PMC1984151

A. H. Youssef and P. Barkhan

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Abstract

Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-¹⁴C-aspirin was significantly greater than that of carboxyl-¹⁴C-aspirin.

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Selected References

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Barkhan, P; Youssef, A. Effect of salicylates on human platelets. Lancet. 1968 Aug 10;2(7563):359. [PubMed]
BUHLER, DR. A simple scintillation counting technique for assaying C1402 in a Warburg flask. Anal Biochem. 1962 Nov;4:413–417. [PubMed]
Evans, G; Packham, MA; Nishizawa, EE; Mustard, JF; Murphy, EA. The effect of acetylsalicyclic acid on platelet function. J Exp Med. 1968 Nov 1;128(5):877–894. [PubMed]
Farbiszewski, R; Lipiński, B; Niewiarowski, S; Poplawski, A. Hypercoagulability and thrombocytopenia after platelet factor 4infusion into rabbits. Experientia. 1968 Jun 15;24(6):578–579. [PubMed]
Niewiarowski, S; Farbiszewski, R; Poplawski, A. Neutralization of antithrombin VI (fibrinogen breakdown products) with platelet antiheparin factor (platelet factor 4). Thromb Diath Haemorrh. 1965 Nov 15;14(3-4):490–499. [PubMed]
Niewiarowski, S; Lipiński, B; Farbiszewski, R; Poplawski, A. The release of platelet factor 4 during platelet aggregation and the possible significance of this reaction in hemostasis. Experientia. 1968 Apr 15;24(4):343–344. [PubMed]
O'Brien, JR. Effects of salicylates on human platelets. Lancet. 1968 Apr 13;1(7546):779–783. [PubMed]
O'Brien, JR. Effect of anti-inflammatory agents on platelets. Lancet. 1968 Apr 27;1(7548):894–895. [PubMed]
Pinckard, RN; Hawkins, D; Farr, RS. In vitro acetylation of plasma proteins, enzymes and DNA by aspirin. Nature. 1968 Jul 6;219(5149):68–69. [PubMed]
Weiss, HJ; Aledort, LM. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet. 1967 Sep 2;2(7514):495–497. [PubMed]
Weiss, HJ; Aledort, LM; Kochwa, S. The effect of salicylates on the hemostatic properties of platelets in man. J Clin Invest. 1968 Sep;47(9):2169–2180. [PubMed]
Youssef, A; Barkhan, P. Release of platelet factor 4 by adenosine diphosphate and other platelet-aggregating agents. Br Med J. 1968 Mar 23;1(5594):746–747. [PubMed]