LOCUS       NP_625717                347 aa            linear   BCT 26-SEP-2008
DEFINITION  integral membrane protein [Streptomyces coelicolor A3(2)].
ACCESSION   NP_625717
VERSION     NP_625717.1  GI:21219938
DBSOURCE    REFSEQ: accession NC_003888.3
KEYWORDS    complete genome.
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
            Streptomycineae; Streptomycetaceae; Streptomyces.
REFERENCE   1  (residues 1 to 347)
  AUTHORS   Bentley,S.D., Chater,K.F., Cerdeno-Tarraga,A.M., Challis,G.L.,
            Thomson,N.R., James,K.D., Harris,D.E., Quail,M.A., Kieser,H.,
            Harper,D., Bateman,A., Brown,S., Chandra,G., Chen,C.W., Collins,M.,
            Cronin,A., Fraser,A., Goble,A., Hidalgo,J., Hornsby,T., Howarth,S.,
            Huang,C.H., Kieser,T., Larke,L., Murphy,L., Oliver,K., O'Neil,S.,
            Rabbinowitsch,E., Rajandream,M.A., Rutherford,K., Rutter,S.,
            Seeger,K., Saunders,D., Sharp,S., Squares,R., Squares,S.,
            Taylor,K., Warren,T., Wietzorrek,A., Woodward,J., Barrell,B.G.,
            Parkhill,J. and Hopwood,D.A.
  TITLE     Complete genome sequence of the model actinomycete Streptomyces
            coelicolor A3(2)
  JOURNAL   Nature 417 (6885), 141-147 (2002)
   PUBMED   12000953
REFERENCE   2  (residues 1 to 347)
  AUTHORS   Redenbach,M., Kieser,H.M., Denapaite,D., Eichner,A., Cullum,J.,
            Kinashi,H. and Hopwood,D.A.
  TITLE     A set of ordered cosmids and a detailed genetic and physical map
            for the 8 Mb Streptomyces coelicolor A3(2) chromosome
  JOURNAL   Mol. Microbiol. 21 (1), 77-96 (1996)
   PUBMED   8843436
REFERENCE   3  (residues 1 to 347)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2002) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   4  (residues 1 to 347)
  AUTHORS   Bentley,S.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2002) Sanger Institute, Wellcome Trust Genome
            Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CAB61656.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Streptomyces coelicolor A3(2)"
                     /strain="A3(2)"
                     /db_xref="taxon:100226"
     Protein         1..347
                     /product="integral membrane protein"
                     /calculated_mol_wt=37585
     Region          21..198
                     /region_name="DUF21"
                     /note="Domain of unknown function DUF21; pfam01595"
                     /db_xref="CDD:110589"
     Region          223..316
                     /region_name="CBS_pair_CorC_HlyC_assoc"
                     /note="This cd contains two tandem repeats of the
                     cystathionine beta-synthase (CBS pair) domains associated
                     with the CorC_HlyC domain. CorC_HlyC is a transporter
                     associated domain. This small domain is found in Na+/H+
                     antiporters, in proteins involved in...; cd04590"
                     /db_xref="CDD:73090"
     CDS             1..347
                     /locus_tag="SCO1435"
                     /gene_synonym="SC6D7.04"
                     /coded_by="complement(NC_003888.3:1531792..1532835)"
                     /note="SC6D7.04, possible integral membrane protein, len:
                     347 aa. Highly similar to many proteins of unknown
                     function including: Mycobacterium tuberculosis
                     SW:YI41_MYCTU (EMBL:Z83859) hypothetical 36.7 KD protein
                     (345 aa), fasta scores opt: 884 z-score: 1036.1 E(): 0
                     43.8% identity in 349 aa overlap and Streptomyces
                     coelicolor TR:CAB53285 (EMBL:AL109972) integral membrane
                     protein SCJ9A.24C (339 aa), fasta scores: opt: 705
                     z-score: 827.6 E():0 36.1% identity in 327 aa overlap.
                     Also similar to the adjoining CDS SC6D7.03 (443 aa), fasta
                     scores: opt: 651 z-score: 666.6 E(): 8.9e-32 36.6%
                     identity in 344 aa overlap. Contains a Pfam matches to
                     entries PF01595 DUF21, Domain of unknown function and 2x
                     Pfam match to entry PF00571 CBS, CBS domain. Also contains
                     a possible N-terminal signal sequence and possible
                     membrane spanning hydrophobic domains"
                     /transl_table=11
                     /db_xref="GeneID:1096861"
ORIGIN      
        1 msvlqllfaa llvlangffv gaefalvsvr rsqieplgtt rarqvlygle rlpqmmaaaq
       61 fgitvcsltl gavaeptvah llepvfewih lphgmihplg yvialavvvf chlvigemvp
      121 knlamaapek aalwlspglv afarlcrpit valgacaqgi lrlfhvepkd eveavftseq
      181 lnrlvedagq aglldpeeqe rledalelgs hpvtdvllpr eslvtvspsv tpgeivalta
      241 rtgysrfpia adqgafmgyl hvkdvldlee sdravpqhlw rpmttlrpel plddaltvmr
      301 raathlaqvt dpsgrilglv aledvlellv gevrdpahrn revtlat
//