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PUMA2 -- Evolutionary Analysis of Metabolism | |
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PUMA2 is not being maintained or updated by Argonne National Laboratory and will be taken down in the near future. If there is any data here that you wish to preserve, you are responsible for downloading it. An overview of the bioinformatics research being conducted at the Mathematics and Computer Science Division is available at this page. |
| EC-number: 3.1.1.77 ----- acyloxyacyl hydrolase |
| EC-NUMBER | 3.1.1.77 | |
| ENZYME-NAME | acyloxyacyl hydrolase | |
| ENZYME-SYSNAME | The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms. It consists of diglucosamine, beta-D-GlcN-(1-> 6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue. Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3. The enzyme from human leucocytes detoxifies the lipid by hydrolysing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS). It also possesses a wide range of phospholipase and acyltransferase activities [e.g. EC 3.1.1.4 (phospholipase A2), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.32 (phospholipase A1) and EC 3.1.1.52 (phosphatidylinositol deacylase)], hydrolysing diacylglycerol and phosphatidyl compounds, but not triacylglycerols. It has a preference for saturated C12-C16 acyl groups. | |
| ENZYME-CLASS | Hydrolases Acting on ester bonds Carboxylic ester hydrolases | |
| SYNONYMS | >>more synonyms | |
| REACTION | 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid [RN:R05792] | |
| PATHWAY | EMP-PATHWAYS: NO EMP PATHWAY FOUND | |
| KEGG-PATHWAYS: NO KEGG PATHWAY FOUND | ||
| GO_TERM | GO:0050528:acyloxyacyl hydrolase activity | |
| ENZYME-COMMENT | NULL | |
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To perform phylogenetic analysis:
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