Hereditary protein S deficiency in young adults with arterial occlusive disease.

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Title:	Hereditary protein S deficiency in young adults with arterial occlusive disease.
Author:	Allaart, C F : Aronson, D C : Ruys, T : Rosendaal, F R : van Bockel, J H : Bertina, R M : Briet, E
Citation:	Thromb-Haemost. 1990 Oct 22; 64(2): 206-10
Abstract:	Protein S is the vitamin K dependent cofactor of activated protein C. It has an important role in the regulation of blood coagulation and fibrinolysis. Hereditary protein S deficiency is associated with familial venous thrombophilia. Since a few patients with arterial occlusions have been reported to be protein S deficient, it is speculated that hereditary protein S deficiency may be also a risk factor for the development of arterial thrombosis. In a group of 37 consecutive patients with arterial occlusive disease presenting before the age of 45, three patients were found heterozygous for hereditary protein S deficiency. None of the patients had a protein C deficiency or an antithrombin III deficiency. Family investigations showed a clear association between the hereditary deficiency and venous thrombosis, but a relation between the deficiency and arterial thrombosis was less obvious. A review of previous literature on patients with arterial thrombosis and protein S deficiency revealed that more extensive studies are needed to demonstrate whether or not hereditary protein S deficiency is a risk factor for the development of arterial thrombosis.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Journal-Article
Keywords:	Arterial Occlusive Diseases genetics : Glycoproteins deficiency
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