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Cloned Familial Cancer Genes |
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Genetic
Condition |
Main
Cancers |
Gene |
Chromosome
Location |
Year of
Discovery |
 |
Hereditary
Retinoblastoma |
Retinoblastoma
Sarcomas |
RB1 |
13q14.1 |
1986 |
|
Hereditary
Wilms' Tumor |
Wilms' Tumor |
WT1 |
11p13 |
1990 |
|
Li-Fraumeni
Syndrome |
Breast Cancer
Sarcomas
Brain Tumor |
TP53 |
17p13.1 |
1990 |
|
| Neurofibromatosis 1 |
Sarcomas
Brain Tumor |
NF1 |
17q11.2 |
1990 |
|
Familial
Adenomatous
Polyposis |
Colon Cancer
Childhood Liver Cancer
Soft Tissue Sarcomas |
APC |
5q21 |
1991 |
|
von Hippel-Lindau
Syndrome |
Renal Cancer
Pheochromocytoma
Brain Tumor |
VHL |
3p25 |
1993 |
|
Multiple Endocrine
Neoplasia 2 |
Pheochromocytoma
Medullary Thyroid Cancer |
RET |
10p11.2 |
1993 |
|
Tuberous
Sclerosis 2 |
Renal Cancer
Brain Tumor |
TSC2 |
16p13.3 |
1993 |
|
Hereditary
Non-polyposis
Colon Cancer 1 |
Colon Cancer
Endometrial Cancer
Stomach Cancer |
hMSH2 |
2p21 |
1993 |
|
Hereditary
Non-polyposis
Colon Cancer 2 |
Colon Cancer
Endometrial Cancer
Stomach Cancer |
hMLH1 |
3p21.3 |
1994 |
|
Hereditary
Non-polyposis
Colon Cancer 3 |
Colon Cancer
Endometrial Cancer
Stomach Cancer |
hPMS1 |
2q32 |
1994 |
|
Hereditary
Non-polyposis
Colon Cancer 4 |
Colon Cancer
Endometrial Cancer
Stomach Cancer |
hPMS2 |
7p22 |
1994 |
|
Hereditary
Melanoma 1 |
Melanoma |
CDKN2 |
9p21 |
1994 |
|
Hereditary
Breast Cancer 1 |
Breast Cancer
Ovarian Cancer |
BRCA1 |
17q21 |
1994 |
|
Hereditary
Breast Cancer 2 |
Breast Cancer
Ovarian Cancer |
BRCA2 |
13q12.3 |
1995 |
|
Hereditary Mulitiple
Exostoses 1 |
Chondrosarcoma |
EXT1 |
8q24.1 |
1995 |
|
Hereditary Multiple
Exostoses 2 |
Chondrosarcoma |
EXT2 |
11p12 |
1996 |
|
Hereditary
Melanoma 2 |
Melanoma |
CDK4 |
12q14 |
1996 |
|
| |
|
Cloned Familial Cancer Genes
(continued) |
| |
Genetic
Condition |
Main
Cancers |
Gene |
Chromosome
Location |
Year of
Discovery |
|
Basal Cell
Nevus Syndrome |
Skin Cancer
Childhood Brain Cancer |
PTCH |
9q22.3 |
1996 |
|
Tuberous
Sclerosis 1 |
Renal Cancer
Brian Tumor |
TSC1 |
9q34 |
1996 |
|
Hereditary Papillary
Renal Carcinoma |
Renal Cancer |
MET |
7q31 |
1997 |
|
Hereditary
Non-polyposis
Colon Cancer 5 |
Colon Cancer
Endometrial Cancer
Stomach Cancer |
hMSH6/
GTBP |
2p16 |
1997 |
|
Multiple Endocrine
Neoplasia 1 |
Endocrine Tumors
Carcinoids |
MEN1 |
11q13 |
1997 |
|
| Cowden Disease |
Breast Cancer
Thyroid Cancer |
PTEN |
10q23.3 |
1997 |
|
Familial
Gastric Cancer |
Gastric Cancer |
CDH1 |
16q22.1 |
1998 |
|
Hereditary
Non-polyposis
Colon Cancer 6 |
Colon Cancer |
TGFBR2 |
3p22 |
1998 |
|
Peutz-Jeghers
Syndrome |
Gastrointestinal Cancers
Breast and Other
Cancers |
LKB1/
STK11 |
19p13 |
1998 |
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| Juvenile Polyposis |
Colon Cancer |
SMAD4/
DPC4 |
18q21.1 |
1998 |
|
Familial
Gastrointestinal
Stromal Tumors (GIST) |
GIST |
KIT |
4q12 |
1998 |
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