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Cloned Familial Cancer Genes | ||||
Genetic Condition |
Main Cancers |
Gene | Chromosome Location |
Year of Discovery |
Hereditary Retinoblastoma |
Retinoblastoma Sarcomas |
RB1 | 13q14.1 | 1986 |
Hereditary Wilms' Tumor |
Wilms' Tumor | WT1 | 11p13 | 1990 |
Li-Fraumeni Syndrome |
Breast Cancer Sarcomas Brain Tumor |
TP53 | 17p13.1 | 1990 |
Neurofibromatosis 1 | Sarcomas Brain Tumor |
NF1 | 17q11.2 | 1990 |
Familial Adenomatous Polyposis |
Colon Cancer Childhood Liver Cancer Soft Tissue Sarcomas |
APC | 5q21 | 1991 |
von Hippel-Lindau Syndrome |
Renal Cancer Pheochromocytoma Brain Tumor |
VHL | 3p25 | 1993 |
Multiple Endocrine Neoplasia 2 |
Pheochromocytoma Medullary Thyroid Cancer |
RET | 10p11.2 | 1993 |
Tuberous Sclerosis 2 |
Renal Cancer Brain Tumor |
TSC2 | 16p13.3 | 1993 |
Hereditary Non-polyposis Colon Cancer 1 |
Colon Cancer Endometrial Cancer Stomach Cancer |
hMSH2 | 2p21 | 1993 |
Hereditary Non-polyposis Colon Cancer 2 |
Colon Cancer Endometrial Cancer Stomach Cancer |
hMLH1 | 3p21.3 | 1994 |
Hereditary Non-polyposis Colon Cancer 3 |
Colon Cancer Endometrial Cancer Stomach Cancer |
hPMS1 | 2q32 | 1994 |
Hereditary Non-polyposis Colon Cancer 4 |
Colon Cancer Endometrial Cancer Stomach Cancer |
hPMS2 | 7p22 | 1994 |
Hereditary Melanoma 1 |
Melanoma | CDKN2 | 9p21 | 1994 |
Hereditary Breast Cancer 1 |
Breast Cancer Ovarian Cancer |
BRCA1 | 17q21 | 1994 |
Hereditary Breast Cancer 2 |
Breast Cancer Ovarian Cancer |
BRCA2 | 13q12.3 | 1995 |
Hereditary Mulitiple Exostoses 1 |
Chondrosarcoma | EXT1 | 8q24.1 | 1995 |
Hereditary Multiple Exostoses 2 |
Chondrosarcoma | EXT2 | 11p12 | 1996 |
Hereditary Melanoma 2 |
Melanoma | CDK4 | 12q14 | 1996 |
Cloned Familial Cancer Genes (continued) | ||||
Genetic Condition |
Main Cancers |
Gene | Chromosome Location |
Year of Discovery |
Basal Cell Nevus Syndrome |
Skin Cancer Childhood Brain Cancer |
PTCH | 9q22.3 | 1996 |
Tuberous Sclerosis 1 |
Renal Cancer Brian Tumor |
TSC1 | 9q34 | 1996 |
Hereditary Papillary Renal Carcinoma |
Renal Cancer | MET | 7q31 | 1997 |
Hereditary Non-polyposis Colon Cancer 5 |
Colon Cancer Endometrial Cancer Stomach Cancer |
hMSH6/ GTBP |
2p16 | 1997 |
Multiple Endocrine Neoplasia 1 |
Endocrine Tumors Carcinoids |
MEN1 | 11q13 | 1997 |
Cowden Disease | Breast Cancer Thyroid Cancer |
PTEN | 10q23.3 | 1997 |
Familial Gastric Cancer |
Gastric Cancer | CDH1 | 16q22.1 | 1998 |
Hereditary Non-polyposis Colon Cancer 6 |
Colon Cancer | TGFBR2 | 3p22 | 1998 |
Peutz-Jeghers Syndrome |
Gastrointestinal Cancers Breast and Other Cancers |
LKB1/ STK11 |
19p13 | 1998 |
Juvenile Polyposis | Colon Cancer | SMAD4/ DPC4 |
18q21.1 | 1998 |
Familial Gastrointestinal Stromal Tumors (GIST) |
GIST | KIT | 4q12 | 1998 |
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