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Title DISTRIBUTION AND EXCRETION OF NIOBIUM-95 IN RATS FOLLOWING DAILY ADMINISTRATION IN THE FOOD AND DRINKING WATER
Creator/Author Thomas, R.G. ; Lie, R. ; Djuric, D. ; Feola, J. ; Scott, J.K.
Publication Date1960 Dec 15
OSTI IdentifierOSTI ID: 4041184
Report Number(s)UR-584
Resource TypeTechnical Report
Research OrgRochester, N.Y. Univ. Atomic Energy Project
SubjectBIOLOGY AND MEDICINE; BLOOD; FOOD; GAMMA RADIATION; INTESTINE; METABOLISM; NIOBIUM 95; RATS; STOMACH; TISSUES; WATER
Description/Abstract Tracer Nb/sup 95/ in oxalic acid solution was added to the food and drinking water of rats and fed daily for thirteen and twelve days, respectively. Serial sacrifices for limited tissue distribution studies were performed throughout and following the feeding period. All food administered, food remaining, excreta, and the whole animals were measured for their gamma activity of the isotope, to permit a balance study. Recovery throughout was approximately- 94 per cent. Ninety-nine to ninety-nine per cent of the niobium ingested. either mixed with food or drinking water, passed directly through the gastrointestinal (GI) tract. The amount entering blood brought the body burden (whole animal mimus GI tract and contents) to a steady state value after just a few days of continued ingestion. This steady state value was between two and five per cent of the average daily intake. There is no indication from these data that the currently recommended maximum permissible concentration in water (3 x 10/sup 03/ mu c/cc for a 40-hour work week) is not valid. (auth)
LanguageEnglish
FormatPages: 21
System Entry Date2001 Jun 03

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