BERNARD E, FARHAD R, FOSSE T, BLANC V, NERI D, DELLAMONICA P; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. L-1967.
University hospital, Nice, France.
BACKGROUND: Data concerning infection due to S.bovis are currently evolving. The objective of our study was to determine the incidence rate of S. bovis bacteremia and analysis of epidemiological, microbiological and clinical features. METHODS: retrospective study over a 4 year period of the cases of S.bovis bacteremia diagnosed in Nice university hospital and in two general hospitals. Antibiotic susceptibility to penicillin (pen), tetracycline (tet), erythromycin (ery), streptomycin (str) and kanamycin (kan) was studied by the antibiogram diffusion and Etest MIC methods. The biotype and the PFGE band pattern were determined. T student test and Chi2 with Fisher adjustement were used for the stastitical analysis. RESULTS: 64 patients (38 male, 26 female) with a mean age of 71.3 years were included representing an incidence rate of 30,6 for 100 gram positive cocci blood cultures. Clinical presentation included fever in 90.6% of the cases, endocarditis in 35.9% and a known digestive portal of entry in 29,7%. Outcome was unfavorable in 29.7% of cases. The biotypes were as follows: I (56.9%), II1 (29.7%) and II2 (29.7%). According to susceptibility (S) or resistance (R) 3 main phenotypes were observed: penSeryStetSstrSkanS (21.9% of the strains), eryR and/or tetR (32.8%) and eryRtetRstrRkanR (42.2%). A clonal transmission was not detected on PFGE analysis. A significant correlation was shown between biotype I and endocarditis (p=0.003); however, the clinical outcome and the antibiotype were not associated to a specific biotype. Conclusion: The clinical presentation of S.bovis bacteremia may be severe. The high rate of multiresistant strains has to be taken into account in the choice of the treatment. The clinical implication of biotype II in human pathology needs to be clarified.
Publication Types:
Keywords:
- Bacteremia
- Electrophoresis, Gel, Pulsed-Field
- Endocarditis
- Female
- Hospitals, University
- Humans
- Male
- Microbial Sensitivity Tests
- Penicillin G
- Penicillins
- Phenotype
- Retrospective Studies
- Streptococcus bovis
- analysis
- genetics
Other ID:
UI: 102267440
From Meeting Abstracts