Voronin E, Frolova OP, Priymak AA, Rakhmanova AG, Selizarova EM, Vlasov NN, Ckaika NA; International Conference on AIDS.
Int Conf AIDS. 1998; 12: 294 (abstract no. 22160).
UST-Izhora Hospital, St. Petersburg, Russia.
OBJECTIVES: To compare the effectivity of tuberculin tests in the diagnosis of tuberculosis (TB) in HIV positive persons at different stages of infection. DESIGN: Comparative prospective study in experimental and control groups. METHODS: Intracutaneous tests with 2 international units (IU) of purified tuberculin were performed in patients with different stages of HIV infection without TB (early stage-23 patients, late stage-31) and in HIV positive persons with proven TB diagnosis (early stage of HIV infection-12, late stage-15 patients). The influence of antiviral therapy with Retrovir (Glaxo Wellcome) on results of tuberculin tests was analysed too. RESULTS: During last year over 300 patients and healthy persons were tested with tuberculin and over 600 tests were performed. During early stages of HIV infection the sensitivity of tuberculin tests in patients was very high and equal to control groups. At the same time in 80 percent of patients with late stages of HIV infection and AIDS partial or complete anergy to tuberculin was found. During the combined therapy with Retrovir the sensitivity of tuberculin tests in HIV patients has increased significantly. CONCLUSION: Intracutaneous tests with 2 IU of purified tuberculin should be used in HIV positive persons to diagnose early stages of TB infection. Antiviral therapy with Retrovir increased the sensitivity of tuberculin tests. The dynamics in results of these tests can be used for effective chemoprophylaxis of TB in HIV positive persons.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- HIV Infections
- HIV Seropositivity
- Humans
- Infection
- Longitudinal Studies
- Prospective Studies
- Tuberculin Test
- Tuberculosis
Other ID:
UI: 102228199
From Meeting Abstracts