Gourevitch MN, Hartel D, Schoenbaum EE, Klein RS; National Conference on Human Retroviruses and Related Infections.

Program Abstr Second Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 2nd 1995 Wash DC. 1995 Jan 29-Feb 2; 73.

Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.

Objectives: We investigated the sensitivity (sens) and specificity (spec) of the tuberculin antigen of a device widely used to test HIV (+) persons for cutaneous anergy (Multitest CMI(R), Merieux, Miami). Methods: Patients (pts) in a study of HIV in drug users receiving methadone treatment were tested for anergy with the Multitest CMI(R) device and for TB infection with PPD (5 TU, Mantoux method). Pts with greater than 2mm induration at 48-72 hrs to PPD or to the tuberculin antigen of the Multitest device were classified as reactors. All tests were read by the same staff. Results: 273 pts received PPD and Multitest testing less than or equal to 3 days apart. There was excellent correlation between size of induration to PPD and to Multitest tuberculin for 111 HIV (+) pts (r=0.86; 95% CI 0.80-0.90) and 162 HIV (-) pts (r=0.71; 95% CI 0.62-0.78). 47/49 PPD reactors reacted to Multitest tuberculin (sens=96%). 53/224 PPD non-reactors had greater than or equal to 2mm induration to Multitest tuberculin (spec=76%). Spec increased to 81%, 94% and 99% as induration to Multitest TB antigen increased from greater than or equal to 5 to greater than or equal to 7 to greater than of equal to 10mm, respectively. Neither sens nor spec of Multitest tuberculin reactions was associated with HIV status. Conclusions: The tuberculin antigen of the Multitest(R) CMI device appears as sensitive as PPD for detecting TB infection In HIV (+) and HIV (-) persons. The spec of the Multitest tuberculin reaction increases in proportion to the degree of induration. Possible contribution of infection with atypical mycobacteria to Multitest tuberculin antigen indurations of small to medium size merits investigation. The tuberculin antigen of the Multitest device may be an excellent test for ruling out tuberculous infection in non- anergic pts.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antigens
• HIV Infections
• HIV Seropositivity
• Humans
• Sensitivity and Specificity
• Tuberculin
• Tuberculin Test
• Tuberculosis
• immunology

Other ID:

• 95920136

UI: 102213081

From Meeting Abstracts