Sheue-yann Cheng
National Institutes of Health
Building 37, Room: 2D-24
Bethesda, Maryland 20892
Phone: (301) 496-4280
Fax: (301) 480-9676
Email: sycheng@helix.nih.gov
Research Interests
Mechansims of thyroid hormone action.
Structure and function of thyroid
hormone receptors.Gene regulation.
Recent Publications
- Cheng, S.-y., Ransom, S.C., McPhie, P., Bhat, M.K., Mixson, A.J., and
Weintraub, B.D. (1994)
Analysis of the binding of 3,3',5-triiodo-L-thyronine and its analogues to
mutant human beta thyroid hormone receptors: A model of the hormone binding
site. Biochemistry 33: 4319-4326.
- Edwards, J. G., Bahl, J.J., Flink, I.L., Cheng, S.-y., and Morkin, E.
(1994)
Effects of thyroid hormone on regulation of human beta myosin heavy chain
expression in fetal rat heart cells. Biochem. Biophys, Res. Comm.
199: 1482-1488.
- Bhat, M.K., Ashizawa, K., and Cheng, S.-y. (1994)
Phosphorylation enhances the target gene sequence-dependent dimerization of
thyroid hormone receptor with retinoid X receptor. Proc. Natl. Acad. Sci.
USA 91: 7927-7913.
- Lin, K.h., Lin, Y.-w., Parkison, C., and Cheng, S.-y. (1994)
Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly
differentiated human hepatocarcinoma cells overexpressing beta thyroid hormone
receptor. Cancer Lett. 85: 189-194.
- Shi, Y.-B., Liang, V.C.T., Parkison, C., and Cheng, S.-y. (1994)
Tissue-dependent developmental expression of a cytosolic thyroid hormone binding
protein gene in Xenopus: its role in the regulation of amphibian metamorphosis.
FEBS Lett. 355: 612-64.
- Lin, K.-h., Lin, Y-w., McPhie, P., and Cheng, S.y. (1994)
Overexpression of thyroid hormone beta nuclear receptor is associated with an
increased proliferation of human hepatoma cells. Proc. XVI Int. Cancer
Congress 615-622.
- Meier-Heusler, S., Zhu, X., Juge-Aubry, C., Pernin, A., Burger, A.G., Cheng,
S.-y., and Meier, C.A. (1995)
Modulation of thyroid hormone action by mutant thyroid hormone receptors, c-erb
A alpha 2 and peroxisome proliferator-activated receptor: Evidence for
different mechanisms of inhibition. Mol. Cell. Endocrinol. 107:
1-12.
- Wong, R., Zhu, X., Pineda, M.A., Cheng, S.-y., and Weintraub, B.D. (1995)
Cell type dependent modulation of the dominant negative action of human mutant
thyroid hormone beta receptors. Mol. Med. 1: 306-319.
- Cheng, S.-y. (1995)
New insights into the structure and function of the thyroid hormone receptor.
J. Biomed. Sci. 2: 77-89.
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Last modified on Novemer 21, 1995.