NCI Funded Research Portfolio - Z01 BC 010734 Abstract

Z01 BC 010734 (Z01)
Title	Cutaneous Lesions in Neurofibromatosis Type I and Other Pre-cancerous Syndromes
Institution	NCI, Bethesda, MD
Principal Investigator	Hornyak, Thomas	NCI Program Director	N/A
Cancer Activity	N/A	Division	CCR
Funded Amount	$37,561	Project Dates	10/01/2005 - N/A
Fiscal Year	2008	Project Type	Intramural
Research Topics (SICs) w/ Percent Relevance		Cancer Types (Disease Sites) w/ Percent Relevance
Clinical Research (100.0%) Neurofibromatosis (100.0%)		Central Nervous System - Not Including Brain (100.0%)
Common Scientific Outline
Cancer Initiation: Oncogenes and Tumor Suppressor Genes Technology and/or Marker Testing in a Clinical Setting
Abstract	Digital dermatoscopy is used to capture accurately the time-dependent growth of dermal neurofibromas and cafe-au-lait macules and patches on the skin of NF1 patients. Sequential images of lesions on patients and associated biopsies have been performed on pediatric and adult patients. In 2008, the addition of pediatric patients to this project was accomplished. As the study progesses, we anticipate obtaining quantitative information about the rate of lesion development and change in both the pediatric and adult NF1 population. Additionally, we anticipate beginning a study of the rate of change in response to therapy of facial papules on patients with Cowden's syndrome.