Z01 BC 010734 (Z01) | |||
Title | Cutaneous Lesions in Neurofibromatosis Type I and Other Pre-cancerous Syndromes | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hornyak, Thomas | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $37,561 | Project Dates | 10/01/2005 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics (SICs) w/ Percent Relevance | Cancer Types (Disease Sites) w/ Percent Relevance | ||
Clinical Research (100.0%) Neurofibromatosis (100.0%) |
Central Nervous System - Not Including Brain (100.0%) | ||
Common Scientific Outline | |||
Cancer Initiation: Oncogenes and Tumor Suppressor Genes Technology and/or Marker Testing in a Clinical Setting |
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Abstract | Digital dermatoscopy is used to capture accurately the time-dependent growth of dermal neurofibromas and cafe-au-lait macules and patches on the skin of NF1 patients. Sequential images of lesions on patients and associated biopsies have been performed on pediatric and adult patients. In 2008, the addition of pediatric patients to this project was accomplished. As the study progesses, we anticipate obtaining quantitative information about the rate of lesion development and change in both the pediatric and adult NF1 population. Additionally, we anticipate beginning a study of the rate of change in response to therapy of facial papules on patients with Cowden's syndrome. |