The Genetics of DROSOPHILA SUBOBSCURA Populations. V. a Study of Linkage Disequilibrium in Natural Populations between Genes and Inversions of the E Chromosome

Genetics. 1975 June; 80(2): 331–347.

PMCID: PMC1213331

The Genetics of DROSOPHILA SUBOBSCURA Populations. V. a Study of Linkage Disequilibrium in Natural Populations between Genes and Inversions of the E Chromosome

M. Loukas and C. B. Krimbas

Department of Genetics, Agricultural College of Athens, Greece

Received July 26, 1974; Revisions requested November 7, 1974.

This article has been cited by other articles in PMC.

Abstract

The genetics of Hk and Est-9 complex gene have been studied in Drosophila subobscura. While Hk alleles mendelize normally, Est-9 is a complex locus consisting of several very closely linked genes with active and silent alleles. Both genes are located on chromosome E; a detailed genetic map was constructed with the help of visible markers and inversions. Both Hk and Est-9 are included in or are very near to inversions of the E chromosome. While Hk does not show linkage disequilibrium either with Est-9 or inversions, Est-9 does show disequilibrium in two ways: both with inversions and between different Est-9 genes. All natural populations studied show the same kind of association between Est-9 gene combinations and inversions. It is argued that these results are better explained by selection than by neutrality.

Full Text

The Full Text of this article is available as a PDF (1.2M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

Charlesworth, B; Charlesworth, D. A study of linkage disequilibrium in populations of Drosophila melanogaster. Genetics. 1973 Feb;73(2):351–359. [PubMed]
Kojima, K; Gillespie, J; Toari, YN. A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymes. Biochem Genet. 1970 Oct;4(5):627–637. [PubMed]
Mukai, T; Mettler, LE; Chigusa, SI. Linkage disequilibrium in a local population of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1971 May;68(5):1065–1069. [PubMed]
Prakash, S; Lewontin, RC. A molecular approach to the study of genic heterozygosity in natural populations. 3. Direct evidence of coadaptation in gene arrangements of Drosophila. Proc Natl Acad Sci U S A. 1968 Feb;59(2):398–405. [PubMed]