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Title D sub 2 O-induced cell excitation
Creator/Author Andjus, P.R. ; Vucelic, D. (Institute of General and Physical Chemistry, Belgrade (Yugoslavia))
Publication Date1990 May 01
OSTI IdentifierOSTI ID: 6703724
Other Number(s)ISSN0022-2631; CODEN: JMBBB
Resource TypeJournal Article
Resource RelationJournal of Membrane Biology ; Vol/Issue: 115:2
Subject560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells; CELL MEMBRANES-- BIOLOGICAL RADIATION EFFECTS;HEAVY WATER-- RADIATION HAZARDS;POTASSIUM COMPOUNDS-- MEMBRANE TRANSPORT; ALGAE;DIFFUSION
Related SubjectALKALI METAL COMPOUNDS;BIOLOGICAL EFFECTS;CELL CONSTITUENTS;HAZARDS;HEALTH HAZARDS;HYDROGEN COMPOUNDS;MEMBRANES;OXYGEN COMPOUNDS;PLANTS;RADIATION EFFECTS;WATER
Description/Abstract The effects of deuterium oxide (D{sub 2}O) on giant internodal cells of the fresh water alga Chara gymnophylla, were investigated.^D{sub 2}O causes membrane excitation followed by potassium leakage.^The primary effect consists of an almost instantaneous membrane depolarization resembling an action potential with incomplete repolarization.^A hypothesis was proposed which deals with an osmotic stress effect of D{sub 2}O on membrane ion channels followed by the suppression of the electrogenic pump activity.^The initial changes (potential spike and rapid K+ efflux) may represent the previously undetected link between the D{sub 2}O-induced temporary arrest of protoplasmic streaming and the early events triggered at the plasma membrane level as the primary site of D{sub 2}O action.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 123-127
System Entry Date2001 May 13

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