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Title T and B lymphocytes of irradiated, tumor-bearing mice treated with an immunostimulator, pyran
Creator/Author Stylos, W.A. (National Cancer Inst., Bethesdo, MD) ; Chirigos, M.A. ; Lengel, C.R. ; Weiss, J.F.
Publication Date1978 Oct 01
OSTI IdentifierOSTI ID: 6629944
Other Number(s)CODEN: CLIMB
Resource TypeJournal Article
Resource RelationCell. Immunol. ; Vol/Issue: 40:2
Subject560152 -- Radiation Effects on Animals-- Animals; ;CARCINOMAS-- BIOLOGICAL RADIATION EFFECTS;LUNGS-- CARCINOMAS;LYMPHOCYTES-- BIOLOGICAL RADIATION EFFECTS;PYRANS-- BIOLOGICAL EFFECTS; IMMUNE REACTIONS;MICE;SPLEEN;X RADIATION
Related SubjectANIMAL CELLS;ANIMALS;BIOLOGICAL EFFECTS;BIOLOGICAL MATERIALS;BLOOD;BLOOD CELLS;BODY;BODY FLUIDS;CONNECTIVE TISSUE CELLS;DISEASES;ELECTROMAGNETIC RADIATION;HETEROCYCLIC COMPOUNDS;IONIZING RADIATIONS;LEUKOCYTES;MAMMALS;NEOPLASMS;ORGANIC COMPOUNDS;ORGANIC OXYGEN COMPOUNDS;ORGANS;RADIATION EFFECTS;RADIATIONS;RESPIRATORY SYSTEM;RODENTS;SOMATIC CELLS;VERTEBRATES
Description/Abstract The T and B splenic lymphocyte populations of BALB/c mice were determined in Madison lung 109 carcinoma-bearing animals.^Concurrently, some groups of tumored mice were exposed to 500 rads of whole body irradiation and treated with one dose of a nonspecific immunostimulating agent, pyran.^By indirect immunofluorescence, it was found that the percentage of splenic T lymphocytes were significantly depressed in the tumored irradiated mice.^Mitogenic studies revealed that the PHA-sensitive T lymphocytes were more depressed in the tumored irradiated mice than in the corresponding Con A-sensitive T lymphocytes.^Pyran was relatively effective in reconstituting the T cell compartment of these splenic T lymphocytes.^The B cell compartment of the splenic lymphocytes of the tumored irradiated mice was found to be extremely radiosensitive.^Utilizing a specific anti-F(ab`)/sub 2/ serum, no B lymphocytes were detected throughout the duration of testing.^Blastogenic studies using LPS as the mitogenic probe revealed that the incorporation of (/sup 3/H)TdR of the tumored irradiated mice was just slightly higher than background values.^Pyran proved to be relatively ineffective in reconstituting the splenic B cells of the tumored irradiated mice.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 437-444
System Entry Date2001 May 13

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