| Antimicrob Agents Chemother. 1976 July; 10(1): 28–33. | PMCID: PMC429684 |
Antiviral Effect of Pyran Against Systemic Infection of Mice with Herpes Simplex Virus Type 2 Ronald S. McCord, Mary K. Breinig, and Page S. Morahan Department of Microbiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 Abstract The immunomodulator pyran markedly protected 5-week-old mice from lethal intravenous infection with herpes simplex virus type 2. The 50% lethal dose was increased almost 100-fold in pyran-treated mice as compared with controls. Although the protection was not as marked in older mice (10 and 16 weeks old), there was a significant increase in mean survival time. When the pathogenesis of herpesvirus disease was monitored in control and drug-treated mice, the effect of pyran was most evident in the spinal cord, where virus was recovered from 20 of 25 control mice and from only 6 of 25 pyran-treated mice. There was also a significant reduction in the titer of virus present, and virus appeared later in the spinal cord of pyran-treated mice than in control mice. The protective effect of pyran was observed only when the drug was administered 24 h before viral challenge, was seen after both intraperitoneal and intravenous injection, and was not due to direct inactivation of the virus. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (960K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Anderson, FD; Ushijima, RN; Larson, CL. Recurrent herpes genitalis. Treatment with Mycobacterium bovis (BCG). Obstet Gynecol. 1974 Jun;43(6):797–805. [PubMed]
- Baird, LG; Kaplan, AM. Immunoadjuvant activity of pyran copolymer. I. Evidence for direct stimulation of T-lymphocytes and macrophages. Cell Immunol. 1975 Dec;20(2):167–176. [PubMed]
- Baker, MB; Larson, CL; Ushijima, RN; Anderson, FD. Resistance of female mice to vaginal infection induced by Herpesvirus hominis type 2: effects of immunization with Mycobacterium bovis, intravenous injection of specific Herpesvirus hominis type 2 antiserum, and a combination of these procedures. Infect Immun. 1974 Dec;10(6):1230–1234. [PubMed]
- Billiau, A; Desmyter, J; De Somer, P. Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid. J Virol. 1970 Mar;5(3):321–328. [PubMed]
- Billiau, A; Muyembe, JJ; De Somer, P. Mechanism of antiviral activity in vivo of polycarboxylases which induce interferon production. Nat New Biol. 1971 Aug 11;232(2):183–186. [PubMed]
- Blanden, RV. T cell response to viral and bacterial infection. Transplant Rev. 1974;19(0):56–88. [PubMed]
- Catalano, LW, Jr; Baron, S. Protection against herpes virus and encephalomyocarditis virus encephalitis with a double-stranded RNA inducer of interferon. Proc Soc Exp Biol Med. 1970 Feb;133(2):684–687. [PubMed]
- Chirigos, MA; Turner, W; Pearson, J; Griffin, W. Effective antiviral therapy of two murine leukemias with an interferon-inducing synthetic carboxylate copolymer. Int J Cancer. 1969 May 15;4(3):267–278. [PubMed]
- De Clercq, E; De Somer, P. Prolonged antiviral protection by interferon inducers. Proc Soc Exp Biol Med. 1969 Nov;132(2):699–703. [PubMed]
- Gutterman, JU; Mavligit, G; Gottlieb, JA; Burgess, MA; McBride, CE; Einhorn, L; Freireich, EJ; Hersh, EM. Chemoimmunotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and bacillus calmette--guérin. N Engl J Med. 1974 Sep 19;291(12):592–597. [PubMed]
- Hamilton, LD; Babcock, VI; Southam, CM. Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids). Proc Natl Acad Sci U S A. 1969 Nov;64(3):878–883. [PubMed]
- Hirsch, MS; Zisman, B; Allison, AC. Macrophages and age-dependent resistance to Herpes simplex virus in mice. J Immunol. 1970 May;104(5):1160–1165. [PubMed]
- JOHNSON, RT. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE. J Exp Med. 1964 Sep 1;120:359–374. [PubMed]
- Kaplan, AM; Morahan, PS; Regelson, W. Induction of macrophage-mediated tumor-cell cytotoxicity by pyran copolymer. J Natl Cancer Inst. 1974 Jun;52(6):1919–1923. [PubMed]
- Kern, ER; Overall, JC, Jr; Glasgow, LA. Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid. Antimicrob Agents Chemother. 1975 Jun;7(6):793–800. [PubMed]
- Larson, CL; Ushijima, RN; Karim, R; Baker, MB; Baker, RE. Herpesvirus hominis type 2 infections in rabbits: effect of prior immunization with attenuated Mycobacterium bovis (BCG) cells. Infect Immun. 1972 Oct;6(4):465–468. [PubMed]
- Merigan, TC; Finkelstein, MS. Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. Virology. 1968 Jul;35(3):363–374. [PubMed]
- Merigan, TC; Regelson, W. Interferon induction in man by a synthetic polyanion of defined composition. N Engl J Med. 1967 Dec 14;277(24):1283–1287. [PubMed]
- Mohr, SJ; Chirigos, MA; Fuhrman, FS; Pryor, JW. Pyran copolymer as an effective adjuvant to chemotherapy against a murine leukemia and solid tumor. Cancer Res. 1975 Dec;35(12):3750–3754. [PubMed]
- Morahan, PS; McCord, RS. Resistance to herpes simplex type 2 virus induced by an immunopotentiator (pyran) in immunosuppressed mice. J Immunol. 1975 Jul;115(1):311–313. [PubMed]
- Morahan, PS; Regelson, W; Munson, AE. Pyran and polyribonucleotides: differences in biological activities. Antimicrob Agents Chemother. 1972 Jul;2(1):16–22. [PubMed]
- Munson, AE; Regelson, W; Lawrence, W, Jr; Wooles, WR. Biphasic response of the reticuloendothelial system (RES) induced by pyran copolymer. J Reticuloendothel Soc. 1970 Mar;7(3):375–385. [PubMed]
- Myers, MG; Oxman, MN; Clark, JE; Arndt, KA. Failure of neutral-red photodynamic inactivation in recurrent herpes simplex virus infections. N Engl J Med. 1975 Nov 6;293(19):945–949. [PubMed]
- Papas, TS; Pry, TW; Chirigos, MA. Inhibition of RNA-dependent DNA polymerase of avian myeloblastosis virus by pyran copolymer. Proc Natl Acad Sci U S A. 1974 Feb;71(2):367–370. [PubMed]
- Richmond, JY; Campbell, CH. Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: effect on adsorption and multiplication in mouse tissues. Arch Gesamte Virusforsch. 1972;36(3):232–239. [PubMed]
- Stevens, DA; Jordan, GW; Waddell, TF; Merigan, TC. Adverse effect of cytosine arabinoside on disseminated zoster in a controlled trial. N Engl J Med. 1973 Oct 25;289(17):873–878. [PubMed]
- Zisman, B; Hirsch, MS; Allison, AC. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. J Immunol. 1970 May;104(5):1155–1159. [PubMed]
|
This article has been 
