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Sponsors and Collaborators: |
Weill Medical College of Cornell University Riverside Research Institute |
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Information provided by: | Weill Medical College of Cornell University |
ClinicalTrials.gov Identifier: | NCT00279695 |
The objective of this research program is to improve diagnosis and treatment monitoring of ophthalmic disease by improving diagnostic ultrasound techniques. The program explores the use of novel signal and imaging processing techniques towards this end.
Condition | Intervention |
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Glaucoma Tumors Age-Related Macular Degeneration |
Procedure: high frequency ultrasound examination |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Ultrasonic Evaluation of Ocular TIssues |
Estimated Enrollment: | 150 |
Study Start Date: | January 1996 |
Estimated Study Completion Date: | June 2009 |
Groups/Cohorts | Assigned Interventions |
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1
Subjects with glaucoma and age-matched normals
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Procedure: high frequency ultrasound examination
high frequency ultrasound examination of the eye
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2
normal volunteers, two age groups, one 18-25 years old, one 50 years and older.
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Procedure: high frequency ultrasound examination
high frequency ultrasound examination of the eye
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3
subjects with tumors of the iris and ciliary body
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Procedure: high frequency ultrasound examination
high frequency ultrasound examination of the eye
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4
subjects with age-related macular degeneration and age-matched normals
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Procedure: high frequency ultrasound examination
high frequency ultrasound examination of the eye
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This study involves the diagnosis of several eye diseases, as follows:
Glaucoma:
Morphometry and spectral parameter assays: Ciliary body drug interactions in patients with initial diagnosis of open angle glaucoma: This study will attempt to document changes in anterior segment functional anatomy related to medical management of glaucoma. We hypothesize that several classes of anti-glaucoma drugs produce permanent modification of ciliary muscle vasculature that is related in turn to loss of drug efficacy over time. Data from COAG patients will be compared with age and sex matched normals. Participation in the study will not effect the ongoing glaucoma therapy of patients.
Accommodation:
Accommodative function in young emmetropes and transitional presbyopes: This is a volunteer study to develop a descriptive model of the human eye's focusing mechanism based on ultrasound morphometric measurements and spectral parameter assays. This study will measure dynamic changes in ciliary body spectral assays (size, CQ2) during calibrated accommodative tasks in volunteers with good amplitude of accommodation and those with accommodative loss do to aging and model 3-D conformal changes in anterior segment structures during accommodation. There is minimal risk that the ultrasound procedure may reveal an occult ocular disease process, but the probability is very small. Patients will be informed and assisted in obtaining appropriate care if any abnormality is seen.
Ocular Tumors
Tumors of the iris and ciliary body: This is an observational study of growth pattern changes in anterior melanoma for the purpose of identifying prognostic variables associated with rapid tumor growth. A percentage of small melanomas are observed for periods of up to several years before demonstrable growth will suggest more aggressive treatment. In the clinical ultrasound practice many patients with these tumors are seen at 3 to 6 month intervals to provide the ophthalmic oncologist with updated tumor volume data. We will examine changes in the ultrasound scattering structure of these tumors over time and their correlation with volume changes. The on-going research data are not released as part of the clinical ultrasound report.
Age-related Macular Degeneration
Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Ophthalmology practice referrals
Inclusion Criteria:
Have one of the following eye diseases Glaucoma Ocular Tumors Age-Related Macular Degeneration
Exclusion Criteria:
none
Contact: Harriet O Lloyd, MS | 212-746-6106 | hlloyd@med.cornell.edu |
Contact: Ronald H Silverman, PhD | 212-746-6106 | ros2012@med.cornell.edu |
United States, New York | |
Weill Cornell Medical College | Recruiting |
New York, New York, United States, 10021 |
Principal Investigator: | D. Jackson Coleman, MD | Weill Cornell Medical College - New York Presbyterian Hospital |
Responsible Party: | Weill Cornell Medical College ( D. Jackson Coleman, MD ) |
Study ID Numbers: | EB00238, 0295-775 |
Study First Received: | January 17, 2006 |
Last Updated: | September 17, 2008 |
ClinicalTrials.gov Identifier: | NCT00279695 |
Health Authority: | United States: Federal Government |
Glaucoma Accommodation Ocular Tumors |
Age-Related Macular Degeneration Ultrasound Eye |
Macular degeneration Eye Neoplasms Glaucoma Eye Diseases Retinal Degeneration |
Macular Degeneration Retinal Diseases Retinal degeneration Hypertension Ocular Hypertension |