University of California at Davis, B.S., 1976, Biochemistry
University of California at Davis, Ph.D., 1983, Pharmacology and Toxicology
University of Arkansas for Medical Sciences, 1983, Post-doctoral training, Behavioral Pharmacology and Toxicology

Experience:

• 1981-1982: Associate-In, Dept. Pharmacology, School of Medicine, University of California at Davis
• 1982-1983: Post-Doctoral Fellow/Instructor, Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences
• 1983-1986: Staff Fellow, National Center for Toxicological Research, Division of Teratogenesis Research, Pharmacodynamics
• 1986-1988: Research Pharmacologist, National Center for Toxicological Research, Division of Reproductive and Developmental Toxicology
• 1988-Present: Head, Behavioral Toxicology Laboratory, Division of Neurotoxicology, National Center for Toxicological Research

Honors:

• Outstanding Student of the Year, Sacramento City College, 1974
• Dreyfus Medical Foundation Research Award, 1984
• NCTR Scientific Achievement Award in Laboratory Science, 1996
• Food and Drug Administration Cash Award, 1985
• Committee on Problems of Drug Dependence Travel Award, 1986
• One Special Service Award, FDA, 1994; three in 1998; one in 1999
• On-the-Spot Cash Award, FDA, 1996
• Time Off Award, FDA, 1997
• Two Group Recognition Awards, FDA, 1997
• Two Cash Awards for Special Act or Service, FDA, 1997; one in 1998
• Equal Opportunity Achievement Award, FDA, 2000

Current Primary Research Interests: Pharmacology and Toxicology

• Behavioral pharmacology and toxicology emphasizing cognitive function deficiencies as indicators of toxicity, developmental perturbations and aging.
• Operant behavioral analyses for quantifying brain functions in children and animal models, particularly nonhuman primates, for animal-to-human extrapolations.
• Demonstrating correlations between operant behaviors and other measures of complex brain function in humans (i.e., IQ scores).
• The pharmacology and toxicology of antiepileptic drugs.
• Developmental pharmacology and toxicology
• Psychotropic drug effects.

Most Recent Publications (from a total of 125 citations):

• Morris, P., Binienda, Z., Gillam, M.P., Klein, J., McMartin, K., Koren, G., Duhart, H. M., Slikker, W., Jr., and Paule, M.G.: The effect of chronic cocaine exposure throughout pregnancy on maternal and infant outcomes in the rhesus monkey. Neurotoxicol. Teratol. 19(1); 47-57, 1997.

• Frederick, D.L. and Paule, M.G.: Effects of MDMA on complex brain function in laboratory animals, Neurosci. Biobehav. Rev. 21:67-78, 1997.

• Frederick, D.L., Gillam, M.P., Lensing, S., and Paule, M.G.: Acute effects of LSD on rhesus monkey operant test battery performance. Pharmacol. Biochem. Behav. 57(4): 633-641, 1997.

• Ferguson, S.A. and Paule, M.G.: Progressive ratio performance varies with body weight in rats. Behav. Process. 40:177-182, 1997.

• Frederick, D.L., Ali, S.F., Gillam, M.P., Gossett, J., Slikker, W., Jr., and Paule, M.G.: Acute effects of dexfenfluramine (D-FEN) and methylenedioxymethamphetamine (MDMA) before and after short-course, high-dose treatment. Ann. N.Y. Acad. Sci. 844:183-190, 1998.

• Paule, M.G., Gillam, M.P. and Morris, P.: The effects of cocaine on nonhuman primate brain function are age-dependent. Ann. N.Y. Acad. Sci. 844:178-182, 1998.

• Paule, M.G., Bushnell, P.J., Maurissen, J.P.J., Wenger, G.R., Buccafusco, J.J., Chelonis, J.J., and Elliott, R. Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humans. Neurotox. Teratol. 20(5): 493-502, 1998.

• Bailey, B., Morris, P., McMartin, K.I., Klein, J., Duhart, H.M., Gillam, M.P., Binienda, Z., Slikker, W., Paule, M.G., and Koren, G.: Transplacental pharmacokinetics of cocaine and benzoylecgonine in plasma and hair of rhesus monkeys. Reprod. Tox. 12(5): 517-523 1998.

• Hashemi, R.R., Terry, M.S., Tyler, A.A., Slikker, W., Jr., and Paule, M.G.: The development of profiles for children with attention deficit disorder and monkeys: a neural network approach. ACM Symposium on Applied Computing, pp. 50-54, 1998.

• Paule, M.G.: Maternal drug abuse and adverse effects on neurobehavior of offspring. In: Handbook of Developmental Neurotoxicology, W. Slikker, Jr. and L.W. Chang, Ed., Academic Press, New York, 1998, pp. 617-629.

• Paule, M.G.: Assessment of behavior in primates. In: Handbook of Developmental Neurotoxicology, W. Slikker, Jr. and L.W. Chang, Ed., Academic Press, New York, 1998, pp. 427-436.

• Paule, M.G., Chelonis, J.J., Buffalo, E.A., Blake, D.J., and Casey, P.H.: Operant test battery performance in children: correlation with IQ. Neurotox. Teratol. 21(3): 223-230, 1999.

• Paule, M.G., Meck, W.H., McMillan, D.E., McClure, G.Y.H., Bateson, M., Popke, E.J., Chelonis, J.J., and Hinton, S.C.: Symposium overview: The use of timing behaviors in animals and humans to detect drug and/or toxicant effects. Neurotox. Teratol. 21(5): 491-502, 1999.

• Popke, E.J., Allen, S.R., and Paule, M.G.: Effects of acute ethanol on indices of cognitive-behavioral performance in rats, Alcohol 20: 187-192, 2000.

• Popke, E.J., Mayorga, A.J., Fogle, C.M., and Paule, M.G.: Effects of acute nicotine on several operant behaviors in rats, Pharmacol. Biochem. Behavior 65: 247-254, 2000.

• Mayorga, A.J., Fogle, C.M. and Paule, M.G.: Adaptation of a primate operant test battery to the rat: Effects of chlorpromazine. Neurotox. Teratol. 22 (1): 31-39, 2000.

• Mayorga, A.J., Fogle, C.M. and Paule, M.G.: Similar effects of amphetamine and methylphenidate on the performance of complex operant tasks in rats. Behav. Brain Res. 109(1): 59-68, 2000.

• Doerge, D.R., McCullagh, M., Fogle, C.M., Paule, M.G., and Bajic, S.: LC/MS analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma. Rapid Commun. Mass Spectrom. 14: 156-160, 2000.

• Chelonis, J.J., Daniels-Shaw, J.L., Blake, D.J., and Paule, M.G. (2000). Developmental aspects of delayed matching-to-sample task performance in children. In press, Neurotox. Teratol., 2000.

• Paule, M.G., Rowland, A.S., Ferguson, S.A., Chelonis, J.J., Tannock, R., Swanson, J.M., and Castellanos, F.X.: Symposium overview: Attention deficit/hyperactivity disorder (ADHD): characteristics, interventions and models, Neurotoxicol. Teratol. 22: 1-21, 2000.

• Chelonis, J.J., et al.: Methylphenidate Normalizes Recognition Memory in Children Diagnosed with Attention Deficit/Hyperactivity Disorder" accepted, J. Exp. Clin. Psychopharm., 2000.

• Slikker, W., Jr., Beck, B.D., Cory-Slechta, D.A., Paule, M.G., Anger, W.K., and Bellinger, David.: Cognitive tests: interpretation for neurotoxicity. Accepted, Toxicol. Sci., 2000.

• Paule, M.G.: Validation of a behavioral test battery for monkeys. In: Methods of Behavioral Analysis in Neuroscience, J.J. Buccafusco, Ed., CRC Press LLC, Boca Raton, FL, pp. 281-294, 2000.