You are invited to attend a special Lecture on Monday, August 20th.
TIME:ÊÊÊÊÊÊÊÊÊÊÊÊÊÊ 4:00 PM - 5:00 PM
ÊLOCATION:ÊÊÊÊÊÊ The Lipsett Auditorium
ÊSPEAKER:ÊÊÊÊÊÊÊ Jun Shen, Ph.D., speaking on recent 3 T c13 MRS work.Ê Abstract below.
Chief, Unit on Magnetic Resonance Spectroscopy, Molecular Imaging Branch, NIMH
Director, Magnetic Resonance Spectroscopy Core Facility, NIMH
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TITLE "Development of high field MRS techniques for studying neurochemistry in vivo"
ÊABSTRACT:Ê In vivo magnetic resonance spectroscopy (MRS) directly measures chemically specific information. It is the only noninvasive technique for measuring concentration of metabolites from the living brain. When combined with administration of 13C-labeled substrates (e.g., glucose), many metabolic fluxes can be studied in vivo. Starting from the early 1990s, in vivo MRS has been experiencing numerous and exciting technological advances. The availability of high field MRI scanners for both human and animal studies has spurred rapid growth in developing novel techniques to expand the scope of in vivo MRS with dramatically improved sensitivity and spectral/spatial resolution.
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This talk will focus on our recent work in developing high field proton and 13C MRS methods and using them to study brain energetics, glutamate/GABA metabolism and neurotransmitter cycling, as well as in vivo enzymology. Our MRS development at 11.7 Tesla, the highest field strength at which in vivo MRS has ever been attempted, has allowed, for the first time, detection of GABA turnover in vivo. In addition to the static levels of metabolites and metabolic fluxes measured by proton or 13C MRS, our recent discovery of 13C magnetization (saturation) transfer effect of specific enzyme reactions has made it possible to probe the action of several enzymes in vivo, pointing to new directions in 13C MRS technology development and applications.
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For further information contact
Holly A. Giesen
Research Psychologist
Associate Program Administrator
Mood and Anxiety Disorders Program
15K North Drive MSC 2670
Bethesda, MD 20892
301-435-8982
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