METABOLIC ENGINEERING NIH GUIDE, Volume 24, Number 32, September 1, 1995 PA AVAILABLE: PA-95-087 P.T. 34 Keywords: Metabolism Genetics Biology, Cellular Enzymology National Institute of General Medical Sciences National Institute of Diabetes and Digestive and Kidney Diseases PURPOSE The purpose of this program announcement (PA) is to encourage research that will expand the conceptual and experimental basis of metabolic engineering. Basic research that contributes to a quantitative understanding of the integration and control of genetic, catalytic, and transport processes that comprise metabolism is encouraged, as is research to create techniques which facilitate the exploitation of metabolic processes for biomedical uses. Research support mechanisms include research project grants (R01), First Independent Research Support and Transition (FIRST) (R29) awards, and program project grants (P01). INQUIRIES This PA, which describes the research objectives, application procedures, review considerations, and award criteria for this program, may be obtained electronically through the NIH Grant line (data line 301-402-2221) and the NIH GOPHER (gopher.nih.gov), and by mail and email from the program staff listed below. Warren Jones, Ph.D. Division of Pharmacology, Physiology, and Biological Chemistry National Institute of General Medical Sciences 45 Center Drive, MSC 6200 Bethesda, MD 20892-6200 Telephone: (301) 594-5938 FAX: (301) 480-2802 Email: JONESW@gm1.nigms.nih.gov Catherine McKeon, Ph.D. Division of Diabetes, Endocrinology and Metabolic Diseases National Institute of Diabetes and Digestive and Kidney Diseases 45 Center Drive,, Room 5AN-18B - MSC 6600 Bethesda, MD 20892-6600 Telephone: (301) 594-8810 FAX: (301) 480-3503 Email: McKeonC@ep.niddk.nih.gov .