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Our Science – Kashlev Website

Mikhail Kashlev, Ph.D.

Selected Publications
1)  Tchernaenko V, Radlinska M, Lubkowska L, Halvorson HR, Kashlev M, Lutter LC.
DNA Bending in Transcription Initiation.
Biochemistry. 2008. [Journal]
2)  Tchernaenko V, Halvorson HR, Kashlev M, Lutter LC.
DNA Bubble Formation in Transcription Initiation.
Biochemistry. 2008. [Journal]
3)  Lewis DE, Komissarova N, Le P, Kashlev M, Adhya S.
DNA sequences in gal operon override transcription elongation blocks.
J. Mol. Biol. 382: 843-58, 2008. [Journal]
4)  Kireeva ML, Nedialkov YA, Cremona GH, Purtov YA, Lubkowska L, Malagon F, Burton ZF, Strathern JN, Kashlev M.
Transient reversal of RNA Polymerase II active site closing controls fidelity of transcription elongation.
Mol. Cell. 30: 557-66, 2008. [Journal]
5)  Galburt EA, Grill SW, Wiedmann A, Lubkowska L, Choy J, Nogales E, Kashlev M, Bustamante C.
Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner.
Nature. 446: 820-823, 2007. [Journal]
6)  Krasilnikova MM, Kireeva ML, Petrovic V, Knijnikova N, Kashlev M, Mirkin SM.
Effects of Friedreich's ataxia (GAA)n*(TTC)n repeats on RNA synthesis and stability.
Nucleic Acids Res. 35: 1075-84, 2007. [Journal]
7)  Malagon F, Kireeva ML, Shafer BK, Lubkowska L, Kashlev M, Strathern JN.
Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil.
Genetics. 172: 2201-9, 2006. [Journal]
8)  Walter W, Kashlev M, Studitsky VM.
Transcription through the nucleosome by mRNA-producing RNA polymerases.
Meth. Enzymol. 377: 445-60, 2004. [Journal]
9)  Kireeva ML, Hancock B, Cremona GH, Walter W, Studitsky VM, Kashlev M.
Nature of the Nucleosomal Barrier to RNA Polymerase II.
Molecular Cell. 18: 97-108, 2005. [Journal]
10)  Studitsky VM, Walter W, Kireeva M, Kashlev M, Felsenfeld G.
Chromatin Remodeling by RNA Polymerase (review).
Trends Biochem Sci. 29(3): 127-35, 2004. [Journal]
11)  Walter W, Kireeva ML, Studitsky VM, Kashlev M.
Bacterial and yeast RNA Polymerase II Use Similar Mechanism for Transcription through Nucleosomes.
J. Biol. Chem. 278: 36148-36156, 2003. [Journal]
12)  Kireeva ML, Lubkowska L, Komissarova N, Kashlev M.
Double-tagged RNA Polymerase II from Saccharomyces cerevisiae: Assays and Affinity Purification of Biotinylated and Non-Biotinylated Forms of Core Enzyme.
Methods in Enzymology. 370: 138-155, 2003. [Journal]
13)  Komissarova N, Kireeva ML, Becker J, Sidorenkov I, Kashlev M.
Engineering of Elongation Complexes of Bacterial and Yeast RNA Polymerases .
Methods in Enzymology. 371: 233-251, 2003. [Journal]
14)  Walter W, Kireeva ML, Tchernajenko V, Kashlev M, Studitsky VM.
). The fate of the Nucleosome during Transcription by RNA Polymerase II.
Methods in Enzymology. 371: 564-577, 2003. [Journal]
15)  Karamychev VN, Tatusov A, Komissarova N, Kashlev M, Neumann RD, Zhurkin VB, Panyutin IG.
Iodine-125 Radioprobing of E. coli RNA Polymerase Transcription Elongation Complexes.
Methods in Enzymology. 371: 106-120, 2003. [Journal]
16)  Mustaev A, Zaychikov E, Grachev M, Kozlov M, Severinov K, Epshtein V, Korzheva N, Bereshchenko O, Markovtsov V, Lukhtanov E, Tsarev I, Maximova T, Kashlev M, Bass I, Nikiforov V, Goldfarb A.
Cross-linking Studies of RNA Polymerase Active Center. Methods and Strategies.
Methods in Enzymology. 371: 191-206, 2003. [Journal]
17)  Kashlev M, Komissarova N.
Transcription termination: primary intermediates and secondary adducts.
J Biol Chem. 277: 14501-14508, 2002. [Journal]
18)  Komissarova N, Becker J, Solter S, Kireeva M, Kashlev M.
Shortening of RNA:DNA Hybrid in Elongation Complex of RNA Polymerase Is a Prerequisite for Transcription Termination.
Molecular Cell. 10(5): 1151-1162, 2002. [Journal]
19)  Kireeva ML, Walter W, Tchernajenko V, Bondarenko V, Kashlev M, Studitsky VM.
Nucleosome remodeling induced by RNA polymerase II: loss of the H2A/H2B dimer during transcription.
Molecular Cell. 9: 541-552, 2002. [Journal]
20)  Kireeva ML, Komissarova N, Waugh DS, Kashlev M.
The 8-nucleotide-long RNA:DNA hybrid is a primary stability determinant of the RNA polymerase II elongation complex.
J Biol Chem. 275: 6530-6536, 2000. [Journal]
21)  Kireeva ML, Komissarova N, Kashlev M.
Overextended RNA:DNA hybrid as a negative regulator of RNA polymerase II processivity.
J Mol Biol. 299: 325-335, 2000. [Journal]
22)  Sidorenkov I, Komissarova N, Kashlev M.
Crucial role of the RNA:DNA hybrid in the processivity of transcription.
Molecular Cell. 2: 55-64, 1998. [Journal]
23)  Komissarova N, Kashlev M.
Functional topography of nascent RNA in elongation intermediates of RNA polymerase.
Proc Natl Acad Sci USA. 95(25): 14699-704, 1998. [Journal]

This page was last updated on 9/25/2008.