Testing Information

Testing Status of Agents at NTP

CAS Registry Number: 91-22-5

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http://ntp.niehs.nih.gov/go/24334

Selected information from two of the National Library of Medicine's databases: ChemIDPlus1 and HSDB2.

Names (NTP)

  • Quinoline
  • 1-AZANAPHTHALENE
  • BENZOPYRIDINE
  • LEUKOL

Structure

Chemical Structure for CAS Registry Number 91-22-5 from NLM

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Chemical Properties2

Property Description
Color/Form
  • COLORLESS TO BROWN /SRP: TECHNICAL GRADE/
  • Highly refractive/darkens with age
  • Colorless liquid
Odor
  • Penetrating odor, not as offensive as pyridine
  • Unpleasant odor
Taste
  • None found
Boiling Point
  • 237.7 deg C @ 760 mm Hg
Melting Point
  • -14.78 deg C
Molecular Weight
  • 129.16
Corrosivity
  • May attack some forms of plastic
Critical Temperature & Pressure
  • Critical temperature: 509 deg C
Density/Specific Gravity
  • 1.0900 @ 25 deg C/4 deg C
Disassociation Constants
  • pKa= 4.90
Heat of Combustion
  • -8710 cal/g
Heat of Vaporization
  • None found
log P (octanol-water)
  • log Kow= 2.03
pH
  • Weak tertiary base
Solubilities
  • Soluble in alcohol, ether, and carbon disulfide
  • Miscible with oxygenated solvents
  • More sol in hot than cold water; sol in ethanol, ethyl ether, acetone, carbon disulfide and other common organic solvents.
  • In water, 6,110 mg/l @ 25 deg C
Spectral Properties
  • Index of refraction: 1.62683 @ 20 deg C/D
  • MAX ABSORPTION (WATER): 275 NM (LOG E= 3.51), 299 NM (LOG E= 3.46), 312 NM (LOG E= 3.52); SADTLER REFERENCE NUMBER: 1053 (IR, PRISM)
  • Intense mass spectral peaks: 129 m/z (100%), 102 m/z (21%), 51 m/z (17%), 128 m/z (16%)
  • IR: 213 (Sadtler Research Laboratories IR Grating Collection)
  • UV: 320 (Sadtler Research Laboratories Spectral Collection)
  • NMR: 6683 (Sadtler Research Laboratories Spectral Collection)
  • MASS: 579 (Atlas of Mass Spectral Data, John Wiley & Sons, New York)
Surface Tension
  • 45.0 dynes/cm @ 20 deg C
Vapor Density
  • 4.45 (Air= 1)
Vapor Pressure
  • 0.06 mm Hg @ 25 deg C
Relative Evaporation Rate
  • None found
Viscosity
  • 2.997 millipascal second (=cP) at 30 deg C
Other Properties
  • 1 MG/L= 189 PPM; 1 PPM= 5.28 MG/CU M
  • Hygroscopic liquid, absorbs as much as 22% water. ... Forms water sol salts with strong acids: pK 9.5
  • Hydroxyl radical reaction rate constant = 1.16X10-11 cu cm/molecule-sec @ 24 deg C

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Uses2

  • Manuf dyes; prepn hydroxyquinoline sulfate, q.v., niacin. As preservative for anatomical specimens. Solvent for resins abd terpenes.
  • Chem int for 8-hydroxyquinoline, a fungistat; chem int for pharmaceuticals-e.g., antiinfectives; corrosion inhibitor
  • Used as ... a decarboxylation reagent.
  • Used in the manufacture of ... paints.
  • Therap cat: antimalarial
  • Manufacture of copper-8-hydroxyquinolate; flavoring
  • The main application of quinoline is the production of 8-quinolinol, which is obtained by alkali fusion of quinoline-8-sulfonic acid. Quinoline can be used to produce methine dyes and nicotinic acid. Quinoline alone, or as a mixture with isoquinoline and quinoline homologues, is an excellent solvent and extractor, especially for polycyclic aromatic compounds.

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Superlist Classes1

  • Reportable Quantity (RQ) = 5000 lb

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Notes (Sources: NTP,HSDB,RTECS,MESH)1

  • None found

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Other Registry Numbers1

  • 20214-07-7

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)1

  • B-500
  • B 500
  • AI3-01241
  • 1-Azanaphthalene
  • 1-Benzazine
  • Benzopyridine
  • Benzo(b)pyridine
  • Chinoleine
  • Chinoline
  • HSDB 121
  • Leucol
  • Leukol
  • Quinolin
  • USAF EK-218

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Links to Additional Information1

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Footnotes

1 Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

2 Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.

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Web page last updated on May 14, 2008